Clinicopathological features of atypical lipomatous tumors of the laryngopharynx

Atypical lipomatous tumor (ALT) of the laryngopharynx is rare. Here we report five cases to demonstrate their clinicopathological features. The patients were four males and one female, aged 41 to 69 years (median 53.6 years). All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass. Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5). Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT. Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4). Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up. ALT of laryngopharynx is an indolent tumor. Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.     

Preparation of high-affinity rabbit monoclonal antibodies for ciprofloxacin and development of an indirect competitive ELISA for residues in milk

A convenient competitive enzyme-linked immunosorbent assay (ELISA) for ciprofloxacin (CPFX) was developed by using rabbit monoclonal antibodies (RabMAbs) against a hapten-protein conjugate of CPFX-bovine serum albumin (BSA). The indirect competitive ELISA of CPFX had a concentration at 50% inhibition (IC₅₀) of 1.47 ng/ml and a limit of detection (LOD) of 0.095 ng/ml. The mAb exhibited some cross-reactivity, however, not so high with enrofloxacin (28.8%), ofloxacin (13.1%), norfloxacin (11.0%), fleroxacin (22.6%), and pefloxacin (20.4%). And it showed almost no cross-reactivity with other antibiotics or sulfonamides evaluated in this study. The competitive ELISA kit developed here could be used as a screening tool to detect and control illegal addition of CPFX in food products. This kit had been applied to milk detection and the recovery rates from samples spiked by CPFX were in a range of 63.02%–84.60%, with coefficients of variation of less than 12.2%.     

社区伦理、社区法治与社区社会工作相结合的制度性建设探索——以石家庄市为例

不是理想中的、西方的、中国将来的社区,而是生活中的、中国的、现在的社区,亟需特殊的制度性建设。这种建设包括伦理、法治、社会工作三个方位。生活中的社区伦理、法治与社会工作尚处于模糊性和准制度性状态,尚处于有动力源而动力源不足的状态。社区制度性建设,需要社会工作统合的社区伦理、法治和社区工作的三向合作,需要国家统摄的政府推进和整合、社会支持和培育、社区学习和锻炼的三源合一。     

构建地方行政服务体系的实践与思考——以临安市三级行政服务体系建设为例

建设与完善地方行政服务体系是政府对行政生态环境变化所作出的回应。文章结合临安市实践,分析三级行政服务体系建设的现状、成就及问题,并结合国内外行政服务体系建设的经验对进一步完善地方行政服务体系的基本途径做了积极探讨。     

有限灌溉下新麦19氮肥用量试验研究

节水灌溉模式下,不施氮肥能够明显提前成熟,不同氮肥用量对新麦19的生育进程没有明显影响.成穗数在氮肥用量大(12～20 kg/667m2以上)时较高,在氮肥用量少(8 kg/667m2以下)时较低;穗粒数在氮肥用量8～16kg/667m2时较高,不施氮肥的处理穗粒数最少;千粒重随着氮肥用量的增加呈下降趋势.施用氮肥能够明显降低新麦19的黑胚率和秕籽率.全程施氮量为16 kg/667m2(即底肥9.6 kg/667m2、拔节期追肥6.4 kg/667m2)时,产量最高、最经济.     

中职物理教学创新能力的培养

中职物理作为一门承继专业基础和专业课的课程,对中职生综合素质和综合能力的培养有很大的促进作用.     

一类混沌系统基于观测器的滑模变结构反同步

利用滑动模态控制研究了含有不确定项的混沌系统的反同步问题,用极点配置原理设计的切换函数保证了带有非线性项的滑动模态混沌反同步,用指数滑模到达条件设计混沌反同步控制器,在该控制器作用下,滑动模态不受干扰的影响,系统有很好的鲁棒性和快速跟踪能力;切换函数的参数方便确定,所得结果保守性小.     

农民工内涵及其教育基本定位探析

农民工日益成为社会学、经济学等多学科的关注对象,也越来越成为引起媒体、官方等社会多层面讨论的重要问题之一。讨论农民工的教育与培训问题的最基础前提是正确理解＂农民工＂概念的内涵、全面掌握＂农民工＂时代特点。     

“双分”教学在大学生游泳课教学中的运用研究

根据因材施教的原则,针对高校大学生体育基础、游泳技术参差不齐的实际状况,在教学中,探究尝试＂双分＂教学,即分层教学、分类指导的体育教学新教法,使好中差各类学生的体育潜力都得到开发,每位学生各有所获,各尽其长,调动全体学生自主探究、合作发展学习的积极性,促进游泳课教学质量的显著提高。     

高职计算机教学中学习兴趣与自主性培养的策略研究

许多高职院校计算机专业近年来都加大了专业教学改革建设的力度,并加大了对专业实验室以及校外实习基地的投入,其目的都是为了建立了工学结合为主线的教学模式,培养实用型的人才。然而,从实际效果来看,计算机专业的学生学习效果以及毕业后就业的出路均不理想,归其原因是只看到了影响学生在专业学习方面的外在因素,而忽视了学生在整个专业学习过程中自身学习兴趣和自主性培养方面的问题。