中药复方对抑郁模型小鼠学习记忆能力及脑内SDF-1的影响

目的：探讨中药复方枳菊解郁汤对抑郁模型小鼠空间学习记忆能力的影响及其机制。方法：采用多种因素慢性轻度不可预见性应激方式建立抑郁模型小鼠,分别给予小鼠低、中、高剂量枳菊解郁汤处理。采用Morris水迷宫实验,检测小鼠的空间学习记忆能力的变化;通过免疫组织化学方法检测脑内基质细胞衍生因子(SDF-1)的表达。结果：与对照组相比,模型组小鼠的空间学习记忆能力明显下降(P<0.01),SDF-1在海马CA1,CA3,DG及前脑皮层的表达明显降低(P<0.05);与模型组相比,枳菊解郁汤中剂量组小鼠的空间学习记忆能力明显增高(P<0.05),SDF-1在海马CA1,CA3,DG及前脑皮层的表达明显增加(P<0.05)。结论：枳菊解郁汤的抗抑郁作用可能与SDF-1的表达上调有关。     

The Relations Between Early Working Memory Abilities and Later Developing Reading Skills: A Longitudinal Study From Kindergarten to Fifth Grade

This study investigated the relations of early working‐memory abilities (phonological and visual‐spatial short‐term memory [STM] and complex memory and episodic buffer memory) and later developing reading skills. Sixty Hebrew‐speaking children were followed from kindergarten through Grade 5. Working memory was tested in kindergarten and reading in Grades 1, 2, and 5. All memory measures, but phonological STM, correlated with reading up to Grade 5. Regression analyses (with intelligence quotient controlled) demonstrated that phonological complex memory predicted all reading skills in Grade 1, and accuracy in Grade 2. The rather understudied visual‐spatial memory predicted comprehension in Grades 2 (STM) and 5 (complex memory). The results point to an important role of the phonological complex memory in early assessment, and suggest a long‐lasting role of early visual‐spatial memory in predicting variance in reading. Whether this role of the visual‐spatial memory is unique to the Hebrew orthography because of its visual features requires, however, further investigation.     

The citation evolution law of papers published in the same year but different month

To explore the citation evolution of papers published in the same year but different month, we selected papers from a discipline (physical geography), a subject (diabetes: endocrine and metabolism) and a journal (Journal of Biological Chemistry) published in 2005 as research objects. These papers were divided into six groups according to the difference in publication month, and we analyzed citations to these papers for the 9 years after publication. The results showed that within 5 years after papers from physical geography were published, the overall differences in citations of papers in different groups were statistically significant (P < 0.05); after that, the differences were not statistically significant. Within 5 years after papers from diabetes (endocrine and metabolism) were published, the overall differences in citations of papers in different groups were statistically significant (P < 0.05); thereafter, the differences were not statistically significant. Within 7 years after papers from the Journal of Biological Chemistry were published, the overall differences in citations of papers in different groups were statistically significant (P < 0.05); thereafter, the differences were not statistically significant. Citations of papers followed the same pattern irrespective of discipline, subject or journal: citations of papers published in the same year but different month were obviously different in the first few publishing years, but as time went on, only the difference in publication month in a calendar year did not affect the papers' longer‐term citation.     

大数据环境下数字图书馆的基本职能

数字图书馆作为一种信息环境,其基本属性仍是收藏属性,基本职能仍是文献收藏。在大数据环境下,尤其需要重视对数字信息资源的整理与收藏,在这个过程中需要政府的强力支持,数字资源呈缴制度的建立与法律保障,数字图书馆联盟的组织,国家图书馆的核心领导,信息生产商、出版商、网络用户、技术商的合作,图书馆、档案馆、个人用户的协调,以发挥数字图书馆在大数据环境下保存和传承人类文化的基本职能。     

出售、非法提供公民个人信息罪若干问题的研究

侵犯公民个人信息犯罪的客体应为公民个人的信息权以及国家对公民身份的管理秩序,该罪的主体是特殊主体,主观要件为故意。司法实践中侦查取证困难、起诉主体不明确造成了该罪认定中的困难。应明确相关主体的行为规则以及该罪的具体界定标准,并完善公民个人信息保护体系。     

食品物流安全的管理与技术课程教学改革探索

针对食品物流安全管理与技术课程知识面广、内容丰富、实践性强的特点,在教学内容、教学形式、教学手段、考核方式等方面积极进行课程教学改革,注重提升学生的学习主动性,提高课程教学质量。     

匹伐他汀钙对高胆固醇血症患者动脉粥样硬化的影响（英文）

目的:观察匹伐他汀钙对高胆固醇血症患者外周血管的影响。创新点:首次在国内发现匹伐他汀钙能够改善高胆固醇血症患者肱动脉和颈动脉血管内皮功能而且延缓其动脉粥样硬化发展,并首次证实改善内皮功能是匹伐他汀钙延缓其动脉粥样硬化发展的重要原因。方法:按照入选排除标准,选取本院高胆固醇血症患者(HC),完成超声心动图检查的40例。根据剂量不同,分为两个剂量组:1 mg剂量组20例(男性5例,女性15例,平均年龄(55.20±8.35)岁),2 mg剂量组20例(男性9例,女性11例,平均年龄(57.56±6.09)岁)。访视结束后完成超声心动图检查的HC组36例,两个剂量组分别有2人失访。治疗后1 mg剂量组18例(男性3例,女性15例,平均年龄(56.00±7.85)岁),2 mg剂量组18例(男性7例,女性11例,平均年龄(57.79±6.46)岁)。选择本院同期体检中心30例正常人作为对照(年龄和性别均与病例组匹配,男性14例,女性16例,平均年龄(54.94±6.90)岁)。所有研究对象,均经隔夜禁食12~14小时,次日清晨抽取空腹肘静脉血,测定临床生化指标。采用Sequia512彩色多普勒超声诊断仪,应用高分辩率外周血管超声技术,检测HC治疗前后肱动脉血流介导性舒张功能(FMD)、颈动脉结构和功能。结论:经匹伐他汀钙治疗8周后,高胆固醇血症患者血管功能明显改善,表现为FMD升高,僵硬度减小;颈动脉僵硬度和内中膜厚度(IMT)延缓进展与其内皮功能改善密切相关。     

基于后发优势视角的贵州新型工业化实现路径研究

基于后发优势理论,明确贵州走新型工业化道路所具有的后发优势,并着重从贵州产业结构总体情况、工业化程度、工业结构三方面来对贵州工业化现状作出分析,得出贵州工业化程度较低,尚处于初期阶段的结论.据此,提出发展生态产业集群是贵州走新型工业化道路的最佳选择.     

末落士子与零余人的比较

韦痴珠和零余人是不同时代作品中的人物形象,他们有着相似的性格,多愁善感,自卑而又狷狂。他们有相似的历史体验,他们有才华却无法施展,精神陷入了极度苦闷,因而遁入青楼去寻求暂时的精神解脱。虽有暂时的忘却,但始终逃脱不了他们应有的宿命。新时期的零余人身上的挣脱封建传统的痕迹是对韦痴珠等末落文人的提升。