Liquid–Liquid Extraction and Solid Phase Extraction for Urinary Organic Acids: A Comparative Study from a Resource Constraint Setting

Pre analytical process of extraction for accurate detection of organic acids is a crucial step in diagnosis of organic acidemias by GCMS analysis. This process is accomplished either by solid phase extraction (SPE) or by liquid–liquid extraction (LLE). Both extraction procedures are used in different metabolic laboratories all over the world. In this study we compared these two extraction procedures in respect of precision, accuracy, percent recovery of metabolites, number of metabolites isolated, time and cost in a resource constraint setup. We observed that the mean recovery from SPE was 84.1 % and by LLE it was 77.4 % (p value <0.05). Moreover, the average number of metabolites isolated by SPE and LLE was 161.8 ± 18.6 and 140.1 ± 20.4 respectively. The processing cost of LLE was economical. In a cost constraint setting using LLE may be the practical option if used for organic acid analysis.     

减灾与救灾──地震灾害的快速评估及其综合决策

建议借助于现代管理手段，建立我国的地震灾害快速评估和综合决策系统，以利于提高减灾与救灾的快速反应能力。     

Secondary immunization inhibits drug induced apoptosis<Emphasis Type="Italic">in vivo</Emphasis>

Immunization with a proper dose of an antigenic stimulus leads to cell proliferation and antibody response of circulating lymphocytes. We have previously observed that Secondary immunized spleenocytes resist ceramide-mediated apoptosisin vitro. Our present study is aimed at investigating thein vivo effect of immunization on apoptosis. Mice were subjected to either Primary or Secondary dose with Tetanus Toxoid. Unimmunized spleenocytes served as controls. Unimmunized, Primary and Secondary immunized mice were later exposed to chemotherapeutic drugs such as Etoposide/Methotrexate/Vincristine to induce apoptosis. Apoptosis was studied by using the Feulgen reaction on 5μ thin parafin sections of spleen. It was observed that Secondary immunized mice showed a lower percentage of apoptosis as compared to Primary or Unimmunized mice that was subjected to either of the chemotherapeutic drugs. It was thus concluded that Secondary immunization inhibits the process of chemotherapeutic drug induced apoptosis in vivo.     

2000年《Science》载文、作者和引文的统计分析

本文统计了《Science》2000年的论文、作者及其引文，重点讨论了该刊的载文量、论文作者的系统及地区分布，作者的合作度、合著率和引文统计等问题。     

Neutralization theory and online software piracy: An empirical analysis

Accompanying the explosive growth of information technology is the increasing frequency of antisocial and criminal behavior on the Internet. Online software piracy is one such behavior, and this study approaches the phenomenon through the theoretical framework of neutralization theory. The suitability and applicability of nine techniques of neutralization in determining the act is tested via logistic regression analyses on cross-sectional data collected from a sample of university students in the United States. Generally speaking, neutralization was found to be weakly related to experience with online software piracy; other elements which appear more salient are suggested and discussed in conclusion.     

论学习型图书馆组织的创建

论述了学习型图书馆的内涵和图书馆创建学习型组织的必要性,提出了建立学习型图书馆应采取的措施:建立共同的愿景、建立学习的团队、建立学习的激励机制、建立“系统思考”的方法、建立健全的学习机制。     

无边界管理的动因分析及模式构建

无边界管理是一种有效的创新,本文首先从理论上探讨了传统企业管理模式向无边界管理模式的演变;在分析无边界原理的基础上,研究了企业实施无边界管理的动因,并提出了我国石油企业构建“无边界管理模式”的建议。这对目前的国企改革及营造核心能力的企业都有借鉴意义。     

我国战略生物资源大数据及应用

生物资源是国家重要的战略性资源。组学时代的到来催生数据量级的增长将推动生命科学研究向"数据密集型科学"的新范式转变。因此,生物资源的大数据与生物资源本身一样,也已成为国家战略资源,成为国际科技与产业竞争热点和战略制高点。目前,我国亟待加快建设国家级战略生物资源大数据共享平台,建立全面支撑生物资源保存、利用、开发、挖掘和可持续利用的技术体系,形成包括数据质控流程、数据存储中心、数据共享中心和数据转化中心的可对海量数据进行有效管理、高效分析和可用、易用的综合数据系统,支撑我国生物资源前沿领域科学发现和产业创新发展。中国科学院战略生物资源信息平台配合中国科学院战略生物资源服务网络的建设,形成了包括数据管理规范、数据汇集平台、数据门户和数据可视化系统在内的一套完整的数据生态,从而有效地促进了中国科学院战略生物资源数据的集成、共享、挖掘和利用。目前,该平台已经覆盖中国科学院植物园、标本馆、生物遗传资源、实验动物、生物多样性监测网络5类资源的42家单位,集成6 981 465条数据,且全部数据资源都可以通过数据门户进行共享。     

国外高校图书馆写作辅导服务实践及启示

[目的/意义] 国外高校图书馆的写作辅导服务历史悠久、实践丰富,学习和借鉴其具体经验能够为我国开展类似服务提供指导。[方法/过程] 采用网络及文献调研的方法,选取10所具有代表性的国外高校图书馆,开展写作辅导服务现状调查,对其辅导实践进行系统总结。[结果/结论] 我国高校图书馆可以通过成立写作中心、组建学生咨询团队、开展多样化的写作活动等方式进行实践探索。     

智慧阅读服务概念界定及国内相关研究评析

[目的/意义] 对智慧阅读服务概念进行界定,梳理国内近3年的相关研究成果,为该领域的研究发展提供参考。[方法/过程] 在CNKI对2017年以来国内的相关研究成果进行检索,梳理相关研究文献,分析研究热点,归纳智慧阅读服务的分析框架,并对未来的研究进行展望。[结果/结论] 2017年以来国内智慧阅读服务研究成果主要包括智慧阅读服务系统与平台、用户、服务内容与策略、服务评价、服务管理等,智慧阅读服务内容与策略、用户是其中两个研究热点方向,研究较多的热点信息技术是大数据与人工智能技术、虚拟现实技术。智慧阅读服务将是未来的研究热点,技术与用户是未来研究的重点方向。