骨骼肌基因转移系统的建立

以EGFP为标记基因，利用重新构建的pAV-EGFP质粒，采用直接注射方法，进行了离体和在体基因转移研究。实验结果显示，经脂质体包裹后，质粒可以有效地进行细胞转移；DNA表达载体肌肉直接注射后，利用共聚焦显微镜可以在注射点周围的肌细胞观察到绿色荧光蛋白；而在对侧肢PCR和共聚焦显微镜的结果均为阴性。实验结果表明，肌肉直接注射DNA可以在肌肉得到表达，将会为治疗肌肉损伤带来新的方法。     

坐式排球运动员的选材特殊性分析

坐式排球是残疾人奥运会正式比赛项目,2000年我国把坐式排球列为全国残疾人运动会正式比赛项目。经过五年的发展,我国坐式排球运动水平已进入世界六强行列。为了完成2008年北京残奥会上男女双获金牌的战略目标,当前最重要的工作就是加强二线队伍的建设,加大运动员的选材力度。经过三年的跟队研究,总结出坐式排球运动员选材的特殊性:放宽运动员的年龄界限,要求队员有较长的上体和上肢。残障程度:以小腿截肢和两下肢不等长的运动员最适合参加坐式排球运动的训练。在挑选攻手时,注意残障腿与扣球手成反向;在挑选二传手时,残障腿是右腿的运动员更适合。     

对第一次世界大战时意大利中立问题的认识

第一次世界大战时,意大利发表中立宣言,中立选择有其深刻原因:战前意大利同其两个最为重要的劲敌法奥之间的关系发生根本性转变,意法关系由高度紧张走向缓和并趋于稳定,而意奥之间暂时冷却的深刻矛盾渐渐暴露出来,意奥关系至战前已相当紧张;焦利蒂时代的“平衡政策”是中立选择的依据。战时意大利政府决策的转变,新政府期望通过战争谋求强国身份和分享战争果实,将意大利带入其难以负担的世界大战。     

Investigation of Poor Academic Achievement in Children with Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy (DMD) is a neurogenetic developmental disorder that presents with progressive muscular weakness. It is caused by a mutation in a gene that results in the absence of specific products that normally localize to muscle cells and the central nervous system (CNS). The majority of affected individuals have IQs within the normal range, generally with lower verbal than performance IQ scores. Prior work has demonstrated selective deficits on tests of verbal span and immediate memory. For the current study, 26 boys with DMD (and normal intellectual function) and their unaffected siblings were evaluated. Paired comparisons demonstrated that the children with DMD had significantly poorer academic achievement scores than their siblings, even though their vocabulary levels and home and educational environments were comparable. Children with DMD also had more behavioral concerns, physical disabilities, and poorer verbal memory spans. Linear regression indicated that behavioral concerns, executive function, and physical disability did not contribute substantially to academic performance, whereas performance on verbal span did. DMD presents with a selective developmental aberration in verbal span that has wide‐ranging consequences on learning skills.     

冠军由基因决定吗?

本文要点: ◆遗传型是机体全部遗传基因的总和,代表了个体的遗传潜力.在决定个体的解剖、生化、生理、行为等特性或遗传表型(如褐色的眼睛、75kg的体重、50 ml/kg/min的最大摄氧量等)上起主导作用.     

人体惯性参数的实测生物力学研究

人体惯性参数是进行生物力学分析、人类工程学等工作时均需要的人体基本参数。通过活体的实际测量 ,比较中国人体惯性参数和国外人体惯性参数所计算人体总重心位置的差异 ,经统计学数据处理来验证中国人体惯性参数的可靠性 ,研究表明 :中国人体惯性参数比国外人体惯性参数更加适应中国情况 ,应对中国人体惯性参数推广应用     

Neuropsychological classification and treatment of dyslexia.

Evidence shows that initial and advanced learning to read are predominantly mediated by the right and left cerebral hemispheres, respectively. Premature reliance on left-hemispheric reading strategies may result in L-type dyslexia, characterized by hurried and inaccurate reading. P-type dyslexia, characterized by a slow and fragmented style of reading, may result from the inability to shift from the predominant generation of right-hemispheric reading strategies to the predominant generation of left-hemispheric reading strategies. Results of investigations concerning the validity of the L/P-typology are discussed, as are the reading effects of hemisphere-specific and hemisphere-alluding stimulation in children with L- and P-type dyslexia.     

Ensuring Content‐Area Learning by Secondary Students with Learning Disabilities

Three factors tied with secondary student success in content‐area reading are demonstrated: (a) validated teacher‐focused and student‐focused interventions, (b) integrated and comprehensive service delivery systems, and (c) well‐designed, data‐based professional developmental programs. Difficult challenges face secondary students with LD and their teachers with regard to these students’ participation and success in required general education classes. Recently, instructional methods and materials have been developed and validated for promoting these students’ success. Some of them focus on how general education teachers plan and teach their content‐area courses; others focus on giving students the strategies they need to respond independently to the demands of their courses. This article describes these instructional methods, a service‐delivery model for implementing these interventions in secondary schools, and professional‐development mechanisms and administrative support that must be in place for the model to be maintained effectively.