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41.
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Yue-qin Qiu Xue-fen Yang Xian-yong Ma Yun-xia Xiong Zhi-mei Tian Qiu-li Fan Li Wang Zong-yong Jiang 《Journal of Zhejiang University. Science. B》2017,18(6):492-500
The expression of the cell death-inducing DNA fragmentation factor α-like effector (CIDE) family including Cidea, Cideb, and Cidec was significantly increased in mouse and human models of obesity. However, there was less information on these genes’ expression in pigs. Here, we hypothesized that different fat accumulation between lean (Duroc×Landrace×Yorkshire gilts, DLY) and obese (Lantang) pigs was attributed to porcine CIDE-modulating lipid metabolism. Our data showed that Cidea and Cidec were expressed at a high level in adipose tissue, and at a relatively high level in skeletal muscle, whereas Cideb was mainly expressed in the liver in both breeds of pig. Lantang pigs had higher white adipose and skeletal muscle Cidea and Cidec mRNA abundance, and hepatic and muscle Cideb mRNA than DLY pigs. Lipid metabolism-related genes including sterol regulatory element binding protein 1c (SREBP-1c), hepatocyte nuclear factor-4α (HNF-4α), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), fatty acid synthase (FASN), diacylglycerol O-acyltransferase 1 (DGAT1), and DGAT2 showed a higher expression level in adipose tissue from obese pigs than in that from lean pigs. Lantang pigs exhibited higher mRNA abundance for liver SREBP-1c, HNF-4α, and PGC-1α, and higher skeletal muscle SREBP-1c, HNF-4α, PGC-1α, and DGAT2 expression, as compared with DLY pigs. However, the perlipin2 mRNA levels in adipose tissues, liver, and skeletal muscle were significantly lower in obese pigs than in their lean counterparts. Furthermore, plasma non-esterified fatty acid (NEFA), glucose, and triacylglycerol (TAG) levels were greater in obese pigs than in lean pigs. Finally, data from correlation analysis further found that CIDE mRNA expression was positively correlated with back fat thickness (BFT), abdominal fat mass (AFM), and the levels of NEFA, TAG, and glucose in the two breeds. Collectively, these data revealed that the porcine CIDEs possibly modulated lipid metabolism and contributed to the development of fat deposition and obesity in Lantang pigs. 相似文献
44.
吕甜 《襄樊职业技术学院学报》2016,(4):59-62
历年来关于《二十四诗品》的美学研究是层出不穷的,从架构美学到思想美学到生态美学到诗歌美学到理想美学等等,这种高度理论性的美学研究使得整部著作更加具有魅力性。但是这种提炼浓缩后的理论升华在无形中也附加上了论者们的美学理想,使得《二十四诗品》美学价值或多或少地存在着"膨胀"的现象。文章将从美感体验出发,旨在挖掘分析能被直接感知的朦胧美和美的朦胧负担,让《二十四诗品》的美变得更加有迹可循。 相似文献
45.
田丁 《韩山师范学院学报》2001,22(4):122-124,117
高师声乐教学中,要学生掌握和处理好作品的风格、情感、特征;了解作品的体裁、时代背景、民族特色、语言等,都是十分重要的;对全面提高学生的音乐素养,提高声乐教学的整体水平,也是非常必要的。 相似文献
46.
计算机中心计算机实验室工作量非常大,为了适应正常的教学需要,提高教学效果与教学质量,必须进行科学、有效的管理,制定严格的实验室管理制度,建立一套切实可行的软件、硬件系统维护方法。 相似文献
47.
出发点是哲学大厦的地基,对哲学出发点的把握直接关系到对一个哲学体系的理解。在哲学界倡导回到马克思的大方向下,有必要对马克思主义哲学的出发点进行澄清。为了充分、准确地理解马克思主义哲学的出发点,我们追本溯源地探讨了黑格尔如何以“思维与存在的统一”为出发点展开自己的哲学体系,以及马克思如何去其糟粕、取其精华地改造了黑格尔哲学的这一出发点,从而把实践范畴作为自己整个哲学的基础和出发点。 相似文献
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To improve the aerodynamic performance of high-speed trains (HSTs) running in the open air, a multi-objective aerodynamic optimization design method for the head shape of a HST is proposed in this paper. A parametric model of the HST was established and seven design variables of the head shape were extracted. Sample points and their exact values of optimization objectives were obtained by an optimal Latin hypercube sampling (opt. LHS) plan and computational fluid dynamic (CFD) simulations, respectively. A Kriging surrogate model was constructed based on the sample points and their optimization objectives. Taking the total aerodynamic drag force and the aerodynamic lift force of the tail coach as the optimization objectives, the multi-objective aerodynamic optimization design was performed based on a non-dominated sorting genetic algorithm-II (NSGA-II) and the Kriging model. After optimization, a series of Pareto-optimal head shapes were obtained. An optimal head shape was selected from the Pareto-optimal head shapes, and the aerodynamic performance of the HST with the optimal head shape was compared with that of the original train in conditions with and without crosswinds. Compared with the original train, the total aerodynamic drag force is reduced by 2.61% and the lift force of the tail coach is reduced by 9.90% in conditions without crosswind. Moreover, the optimal train benefits from lower fluctuations in aerodynamic loads in crosswind conditions. 相似文献
50.
对近年来化学计量学中的多元校正方法应用情况作一介绍,其应用范围包括金属元素、食用色素、药物、氨基酸等混合多组分的同时测定。 相似文献