Genomic diversity and post-admixture adaptation in the Uyghurs

Population admixture results in genome-wide combinations of genetic variants derived from different ancestral populations of distinct ancestry, thus providing a unique opportunity for understanding the genetic determinants of phenotypic variation in humans. Here, we used whole-genome sequencing of 92 individuals with high coverage (30–60×) to systematically investigate genomic diversity in the Uyghurs living in Xinjiang, China (XJU), an admixed population of both European-like and East-Asian-like ancestry. The XJU population shows greater genetic diversity, especially a higher proportion of rare variants, compared with their ancestral source populations, corresponding to greater phenotypic diversity of XJU. Admixture-induced functional variants in EDAR were associated with the diversity of facial morphology in XJU. Interestingly, the interaction of functional variants between SLC24A5 and OCA2 likely influences the diversity of skin pigmentation. Notably, selection has seemingly been relaxed or canceled in several genes with significantly biased ancestry, such as HERC2–OCA2. Moreover, signatures of post-admixture adaptation in XJU were identified, including genes related to metabolism (e.g. CYP2D6), digestion (e.g. COL11A1), olfactory perception (e.g. ANO2) and immunity (e.g. HLA). Our results demonstrated population admixture as a driving force, locally or globally, in shaping human genetic and phenotypic diversity as well as in adaptive evolution.     

"无线网络原理"双语教学实践与评价

双语教学是我国高等教育教学改革的重要措施之一.文章从教学理念和教学方法相结合的高度,对"无线网络原理"双语教学改革和实践进行了论述分析.     

管理类专业"计算机网络"课程的建设与改革

文章从师资队伍建设、教材建设与教学内容改革、教学方法和教学手段的改革以及学生能力的培养等方面详细介绍了该课程建设与改革的经验,提出了一些改进该课程教学质量的措施,并介绍了通过该课程培养学生能力的有效方法。     

以人才培养模式改革为突破口全面推进本科教学改革

人才培养模式改革是推进本科教学改革的突破口。文章介绍了湖南大学实施的本科人才培养模式以及围绕人才培养模式改革所做的工作。     

浅谈语文课堂教学评价中的人文关怀

工作在教学第一线,我们每天都面对着一个个鲜活的生命,体验着师生间丰富的、涌动的、特殊的生命历程,感受到只有以一个完整生命体的方式参与和投入,才有可能与另外一个完整的生命体进行交往与沟通,才有可能实现自身价值,才有可能取得教学工作的理想效果.     

加强高校感恩氛围的营造,提高辅导员工作质量

加强高校感恩氛围的营造,对大学生树立正确的世界观、人生观、价值观和养成良好的道德品质有积极的促进作用,对家庭经济困难学生健全人格培养起到良好的引导作用,对即将走上社会的毕业生摆正就业心态有切实的指导作用。     

一种改进的基于神经网络的入侵检测算法

径向基神经网络具有良好的分类特性,被广泛应用于入侵检测系统的研究中,然而RBF神经网络需要事先确定隐层神经元数目,并且容易陷入局部最优.利用遗传算法优化隐层神经元数目,并且基于粒子群思想优化隐层到输出层的权值,同时给出了详细的算法流程.经Lincoln实验室入侵检测系统数据评估集合测试,该智能算法的检测成功率大大提高,并且训练时间比较短,完全可以应用于入侵检测系统中.