DEL RBC transfusion should be avoided in particular blood recipient in East Asia due to allosensitization and ineffectiveness

Previously, both primary and secondary anti-D alloimmunizations induced by "Asian type" DEL (RHD1227A allele) were observed in two incidents. We investigated how often these alloimmunization events occur. The transfusions of any D-negative patients were investigated in the First Affiliated Hospital of Xi’an Jiaotong University Medical College, China, during the entire 2009. The antigens of D, C, c, E, and e were routinely serotyped. The "Asian type" DEL variant was genotyped and the RHD heterozygote was determined through two published methods. The changes in anti-D levels were monitored by the indirect antiglobulin test (IAT) and flow cytometry. Thirty D-negative transfused patients were included in the study. We focused on 11 recipients who were transfused with packed red blood cells (RBCs) from DEL donors at least one time. Of those 11 recipients, seven were anti-D negative before transfusion and four were anti-D positive (one patient with an autoantibody). One of the seven pre-transfusion anti-D negative patients produced a primary-response anti-D after being transfused with 400 ml of DEL blood twice. All four pre-transfusion antibody positive patients were not observed hemoglobin (Hb) levels increased, as expected after transfusions. Two patients had an increase in anti-D from 1:8 to 1:64 by IAT, which was also shown by flow cytometry. None of the patients experienced an acute hemolytic episode. Our data indicated that the primary anti-D induced by DEL transfusion or the secondary anti-D elevated by DEL in a truly D-negative patient might not be unusual. We suggest that a truly D-negative childbearing-aged woman should avoid DEL transfusion to protect her from primary anti-D allosensitization. In addition, anti-D positive recipients should also avoid DEL red cell transfusion due to the delayed hemolytic transfusion reaction (DHTR).     

Elevated skin autofluorescence is strongly associated with foot ulcers in patients with diabetes: a cross-sectional, observational study of Chinese subjects

Objective  

This study was designed to evaluate the association between skin autofluorescence (AF), an indicator of advanced glycation end-products (AGEs), and foot ulcers in subjects with diabetes.     

资源 品牌 平台——谈综合性大学音乐专业的定位与发展

本文针对近年来国内综合性大学纷纷建立音乐专业的新现象、新情况,就其如何定位与发展的问题进行分析与构想,分别从利用资源、打造品牌、平台作用这几方面展开多层次的论述。综合性大学利用自身特长和外界良性因素办好音乐专业有助于国内音乐教育水平的整体提高。同时,注意在发展中兼顾共性、发扬个性,立足实际、不断创新,将使得综合性大学音乐专业在未来国内专业音乐教育中占据更加重要的战略地位。     

蒙特卡洛模拟指导量本利分析的案例探究

概率型量本利分析是企业当前常用的分析方法,分析所得的结果可以从不同角度反应企业生产、销售、采购、加工等方面的经济状况。为了保证概率型量本利分析的有序进行,在分析时采用蒙特卡洛模拟辅助研究,能让最终得到的数据结构更加客观、科学。     

高校辅导员心理素质研究述评

文章对近年来关于高校辅导员心理素质的研究进行了梳理,包括高校辅导员心理素质研究的总体状况、高校辅导员心理素质的基本理论研究。对当前研究现状进行了述评,指出了未来高校辅导员心理素质研究的两个致思方向:一是加强辅导员心理素质的系统研究;二是制订本土化的辅导员心理素质的测查工具。     

心理学视野下的我国青少年价值观研究综述

价值观是一个复杂的心理系统,心理学研究者对其界定和研究各有侧重,本文从价值观的基本概念、现有的价值观研究这两个方面对近几年的研究成果进行梳理和总结,对今后的价值观的研究进行了展望,以期为后续研究探寻方向和突破口。     

大学生粗口现象的调查及对策

一些大学生把爆粗口当作个人情绪的宣泄方式和朋辈间的沟通方式.出现粗口现象的主要原因是社会变化带来的心理不适应和大众传媒的误导.应通过营造良好舆论氛围、构建完善的沟通机制、采取正确的情感宣泄方式并在青年学生中倡导良好的人际沟通方式来抵消爆粗口这一不文明行为     

宪政视野中的人肉搜索及其规制——以死亡博客为例

人肉搜索对现实的影响有目共睹,赞叹与质疑之声从未消弥。国家已从地方层面开始试水对其规制,然而却因理论上研究不足使其饱受诟责,并在法律与舆论的边缘徘徊。以死亡博客为例,从宪政视野来分析人肉搜索的实质,可从理论上和实践上提出具体的规制。     

高校图书馆科学数据管理服务能力成熟度模型构建与应用研究

[目的/意义]构建高校图书馆科学数据管理服务能力成熟度模型,为高校图书馆识别与评价其科学数据管理服务能力提供科学的评价标准与量化测评工具,进而实现服务能力的管理、改进和提高.[方法/过程]基于文献调研,初步拟定能力评价指标体系;运用德尔菲法进行专家咨询确定指标体系的合理性;利用层次分析法通过计算专家评分确定指标权重.最...     

浅谈退役运动员如何转型当好班主任

班主任是学校与学生信息传递的桥梁,班主任工作是复杂而又重要的工作。作为一名退役运动员,如何做好这种角色转换?如何从一个专业的竞技体育工作者变为一位负责班级管理、组织和领导的班主任?笔者过去是一名专业的运动员,退役后来到本省一所电大做体育老师,同时担任了一个班的班主任。通过自己两年多的努力,对班主任工作有了一定的了解。在此,笔者想通过自身的一些经历经验,谈一下一名退役运动员如何能尽快转型成为一个合格的班主任,与广大同行分享交流。