Reference intervals for thyroid disorders calculated by indirect method and comparison with reference change values

IntroductionThe aim of the study was to calculate reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) and evaluate the clinical significance of these intervals by use of reference change values (RCV) of the analytes.Materials and methodsLaboratory patient data between August and December 2021 were evaluated for the study. A total of 188,912 patients with TSH, fT4, fT3, anti-thyroid peroxidase antibodies (Anti-TPO) and anti-thyroglobulin antibodies (Anti-Tg) results were evaluated. All measurements were performed on Cobas c801 (Roche Diagnostics, Penzberg, Germany) using electrochemiluminescence immunoassay technology. Estimated RIs were compared with manufacturer’s by means of RCVs of analytes.ResultsThyroid stimulating hormone values didn’t differ significantly by gender and age. The combined RIs for whole group (N = 28,437) was found as 0.41-4.37 mIU/mL. Free T4 values (11.6-20.1 pmol/L, N = 13,479 in male; 10.5-19.5 pmol/L, N = 17,634 female) and fT3 values (3.38-6.35 pmol/L, N = 2,516 in male; 3.39-5.99 pmol/L, N = 3,348 pmol/L in female) significantly differed by gender (P < 0.050). Both fT4 and fT3 values also showed significant differences in age subgroups comparisons. So, male and female RIs were represented separately for age subgroups. When compared with manufacturer’s RIs, TSH whole group and fT4 subgroups RIs didn’t exceed the analytes’ RCVs, but this difference was greater for fT3.ConclusionsReference interval estimation by use of indirect method out of laboratory data may be more accurate than manufacturer provided RIs. This population based RIs evaluated using RCV of analytes may provide useful information in clinical interpretation of laboratory results.     

Beginning early childhood education teachers’ classroom management concerns

This paper reports an analysis of the classroom management concerns of pre-service early childhood education (ECE) teachers prior to beginning their career and further examines the difficulties they experienced in classroom management in their first year of teaching and their coping strategies. Sixteen pre-service ECE teachers enrolled in the same teacher education programme were interviewed immediately before graduation, and were again interviewed at the end of the first and second semesters after they started to work in public schools. Phenomenological analysis was utilized for the data analysis. The findings revealed that all of the participants had a fear of being unable to manage their classes before starting their careers because they felt unprepared. However, they experienced fewer problems than expected after they started to teach. The teachers first tried to build trusting and close relationships with the children to create a peaceful classroom climate, while also attempting to empower the children by involving them in decision-making processes. In this way, the children became aware of the class rules and felt free in their actions within the limits of the rules.     

A Longitudinal Study of the Roots of Preschoolers' Conscience: Committed Compliance and Emerging Internalization

The focus of this study is the complex relation between compliance and internalization in childhood. It is a replication and a longitudinal extension of earlier work, where we distinguished between 2 forms of compliance: committed, when the child eagerly embraced and endorsed the mother's agenda, and situational, when the child was cooperative, but lacked the sincere commitment and feeling of internal obligation. 99 children, seen previously at 26–41 months, were studied again at 43–56 months. Compliance and internalization were assessed in multiple observational contexts and using maternal reports. As at toddler age, the 2 forms of compliance had distinctly different developmental trajectories, and again, only committed compliance was significantly associated with measures of internalization. Moreover, committed but not situational compliance at toddler age predicted internalization at preschool age. Shared positive affect within the mother-child dyad at toddler age predicted some measures of internalization at preschool age. Further evidence of significant differences in children's compliance to maternal "dos" versus "don'ts" is reported.     

Development of mutual responsiveness between parents and their young children

This comprehensive study of mutual responsiveness examined 102 mothers and 102 fathers interacting with their children at 7 and 15 months. Responsiveness was studied from developmental and individual differences perspectives, and assessed using macroscopic ratings and microscopic event coding. The latter captured parents' reactions to children's negative, positive, and physical bids, and children's reactions to parents' social-interactive bids, mood regulation attempts, and influence attempts. Responsiveness depended on bid type and child age, and reflected developmental changes in children, parents, and relationships. Mothers were more responsive than fathers; children were equally responsive to both parents and coherent in their responsiveness. Ratings revealed dyadic mutuality and longitudinal continuity of responsiveness. Parent-child responsiveness from 7 to 15 months was consistent with assumptions of a parent-driven process.     

Mandatory Virtual Design Studio for All: Exploring the Transformations of Architectural Education amidst the Global Pandemic

Virtual design studio (VDS) has been a part of the discourse of architectural pedagogy for the past two decades. VDS has been showcased as a potential educational tool in schools of architecture often in controlled, pre‐designed experiments. However, the global COVID‐19 pandemic has forced most schools to move their design studios into virtual space. This article aims to explore the potential advantages and shortcomings of VDS during the COVID‐19 quarantine from the perspective of students in a department of architecture. The study investigates three aspects of VDS namely, participating students’ evaluation of the virtual studio experience, the effectiveness of VDS in achieving the studio’s expected learning outcomes and the evaluation process for final design projects. Some 360 students from eight consecutive design studios participated in the study. The results indicate improvement in students’ ability to conduct independent research and in learning new computer‐aided design (CAD) software. Furthermore, the study finds VDS to be much more applicable for third‐ and fourth‐year students. The results also show a significant decline in background informal peer learning among students. Further studies are needed to address the implementation of a more immersive social experience in VDS.     

Maternal parenting and children's conscience: early security as moderator

Socialization research is shifting from direct links between parenting and children's outcomes toward models that consider parenting in the context of other factors. This study proposed that the effects of maternal responsive, gentle parenting on child conscience are moderated by the quality of their relationship, specifically, early security. A 2-process model of early conscience development was proposed and confirmed in this longitudinal study. The child's security and trust in the caregiver, assessed at 14 months in the Strange Situation, rendered him or her receptive and eager to accept the caregiver's socialization agenda. That early security then enhanced the effectiveness of parental adaptive parenting style, observed from 14 to 45 months, in terms of promoting conscience at 56 months, which encompassed moral conduct, moral cognition, and moral self.     

Augmented reality-based virtual manipulatives versus physical manipulatives for teaching geometric shapes to preschool children

The aim of the current study is to compare the effect of virtual and physical manipulatives on preschool children’s understanding of geometric shapes. A quasi-experimental research design was employed where children in the experimental group used tablet computers to access Augmented Reality (AR)-based virtual manipulatives, while children in the control group used physical manipulatives. The instruction lasted for a period of four weeks at a public primary school in Turkey with 72 children aged five and six years old. Comparison of their understanding of geometric shapes was based on their scores from pre-test and post-test measures of the Geometric Shape Recognition Task instrument. Analysis of the collected data revealed no statistically significant difference between the groups in the circle recognition task, while statistically significant differences were found between the groups in the recognition tasks for triangle, rectangle, and square shapes in favour of the experimental group. In addition to this, although there was an increase in the total scores of both groups, the results showed a statistically significant difference in test scores in favour of the experimental group. The current study also showed that the children had difficulty in categorising geometric shapes when their attributes were changed, therefore providing different forms of geometric shapes to children is very important for improving their conceptual understanding.     

Exploring the Role of Trust in Scientists to Explain Health-Related Behaviors in Response to the COVID-19 Pandemic

The devastating COVID-19 pandemic has cast a light on the question of why trust in scientists is important. This mixed-method study aimed to explore the study participants’ trust in scientists about getting the COVID-19 vaccine. It also aimed to reveal which key sources of information participants followed about the pandemic. Participants’ health-related behaviors and justifications for their behaviors as a response to the pandemic were also explored to understand how trust in scientists and sources of information played a role in the fight against COVID-19. The responses of 1233 participants across Turkey were analyzed. The findings indicated that trust in scientists and compliance with the scientists’ suggested behaviors among the participants were quite high. It was also revealed that, for both trust and non-trust groups, participants questioned the reliability of information and the sources. Participants justified their behaviors mainly by referring to policies, e.g., masks, distance, and hygiene, developed and implemented with the collaboration of government, scientists, and the World Health Organization. Moreover, trust issues regarding scientists, government authorities, or other citizens were mentioned in participants’ justifications. The current study also shed light on the importance of building trust through an open and healthy dialogue among scientists, government authorities, and the public to overcome the COVID-19 pandemic. The study highlighted the need for scientifically informed citizens to deal with the problems, i.e., misinformation and disinformation, in the post-truth era such as not jeopardizing effective solutions to eliminate the pandemic, e.g., taking the vaccine.

     

Multivariate Assessment of Middle School Students’ Interest in STEM Career: a Profile from Turkey

Research in Science Education - According to a report by the Turkish Industry and Business Association, Turkey will need approximately 1 million individuals to be employed in Science Technology...