从对话的视角看高校图书馆学科服务策略

根据现代对话理论,图书馆的学科服务是学科馆员与学科文献、学科读者之间展开的互动对话.对话的层次与水平直接决定学科服务水平.文章基于学科服务时话要求,提出高校图书馆开展学科服务的建议.     

图书馆危机治理的经济分析与政策选择

图书馆危机不仅是全球图书馆界正在面临的一个严重问题,而且正对全球图书馆事业的稳定发展造成严重威胁。图书馆危机治理是现代经济治理理论与图书馆理论有机结合而提出的一个新课题。深刻剖析图书馆危机治理的特殊内涵,明确指出目前图书馆危机治理中存在的市场失灵问题,并针对此问题提出政府干预与救济才是解决问题的根本方法,从而为我国图书馆危机治理机制的建立和完善提供现实选择。     

加强老字号企业档案管理,弘扬地方文化品牌

老字号企业的档案管理是其文化传承和发展的有效途径,也是弘扬地方文化品牌的珍贵渠道.本文从分析老字号企业档案管理的现状入手,指出这类企业进行档案管理的必要性,提出了老字号企业档案管理工作的几点建议.     

EJB组件技术在数字参考咨询系统中的应用

随着数字图书馆的不断发展,如何构建一个良好的数字参考咨询系统已成为数字图书馆发展中的重要问题。在对EJB多层体系结构分析的基础上,构建了一个基于EJB的数字参考咨询系统,并从面向对象的角度对该平台的设计及实现过程进行了分析。     

中国精品档案解析之二十三保晋公司档案:尽显山西近代保矿风云(下)

四、公司创设 在争矿过程中,山西爱国士绅充分认识到,山西矿产如不自己开采、挖掘,终将为外人所掠.为了"树自办之基,而示争矿之决心",爱国士绅们积极筹划,准备创建以开采全省煤矿为主的近代民族企业.     

智慧化教育导引下的教育扶贫创新及其实现

智慧化教育符合教育扶贫的价值内涵,智慧化教育在教育扶贫的创新工作中具有技术创新、媒介创新、理念创新等内源引擎作用.将智慧化教育与教育扶贫进行创新式融合,通过良好的基因结构、切实可行的技术指标,突破学习者的层层体验,实现"联动创新"的教学模式创新.基于智慧化教育在环境氛围的智慧化、交互媒体的智慧化、教师角色的智慧化、知识...     

"高中政治课教学与考试评价"课题实施方案

一、本课题研究的理论价值和实践意义 1.理论价值 <基础教育课程改革纲要>指出:"改变课程评价过分强调甄别和选拔的功能,发挥评价促进学生发展、教师提高和改进教学实践的功能."面对江苏省高考自主命题,教材的编写与使用面临重大变化的新形势,考试作为一种较为严格的具体评价方式,政治科考试改革为课堂教学的导向无论其功能和价值,还是考试的内容、考试的方式,以及对考试结果的处理甚至对升学考试制度及对推动课堂教学的发展,都是未来教育发展的需要.最大限度地介入学生的成长过程,真正发挥科学评价在促进学生的发展方面的作用,以科学的教育发展观引领教育的健康前行.     

Joint effects of microwave and chromium trioxide on root tip cells of Vicia faba

The mutagemc effects of microwave and chromium trioxide （CrO3） on Vicia faba root tip were studied. Micronucleus assay and chromosomal aberration assay were used to determine the mitotic index, the micronucleus frequency and chromosomal aberration frequency of Vicia faba root tip cells induced by microwave and CrO3. The results showed that the micronucleus frequency decreased, and that the mitotic index and chromosomal aberration frequency showed linear dose responses to CrO3, in treatment of microwave for 5 s. In microwave of 25 s, the mitotic index decreased, the micronucleus frequency and chromosomal aberration frequency increased with increase of CrO3 concentration. We concluded that microwave and CrO3 had antagonistic effect on the mitotic index of Vicia faba root tip cells, but had synergetic effect on micronucleus frequency and chromosomal aberration frequency of Viciafaba root tip cells.     

Science Letters：IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1

Insulin-like growth factor binding-protein-7 （IGFBP7） was obtained from our previous colonic adenocarcinoma （CRC） and normal mucosa suppression subtraction hybridization （SSH） cDNA libraries. By RT-PCR and immunohistochemistry, we found that IGFBP7 was overexpressed in CRC tissue compared to normal tissue. However, our in vitro experiments performed in 10 CRC cell lines showed that IGFBP7 expressed only in SW480 and Caco2 cell lines, which implied an underlying reversible regulatory mechanism. Using methylation-specific PCR （MSP） and bisulfite sodium PCR （BSP）, we found that its expression was associated with DNA hypomethylation of exonl. This was further supported by the in vitro study which showed restored IGFBP7 expression after demethylation agent 5-aza-2＇-deoxycytidine treatment. Correlation analysis between IGFBP7 expression and prognosis indicated that overexpression of IGFBP7 in CRC tissue correlated with favourable survival. Investigation of the functional role of IGFBP7 through transfection studies showed that IGFBP7 protein could inhibit growth rate, decrease colony formation activity, and induce apoptosis in RKO and SW620 cells, suggesting it a potential tumor suppressor protein in colorectal carcinogenesis. In conclusion, our study clearly demonstrated that IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1.     

Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats

Objective： Some animal models apply morphine in the drinking water to generate addiction, but related reports are not free of conflicting results. Accordingly, this study aimed to figure out if chronic consumption of morphine in the drinking water can induce morphine addiction in Wistar rats. Methods： For 3 weeks, the animals received a daily morphine dose of 35 mg/kg by offering a calculated volume of sugar water （5% sucrose） with morphine （0. l mg/ml） to each rat; animals receiving just sugar water served as controls. Immediately after the treatment phase, the tail immersion test was used to check for morphine tolerance, and all animals were then kept on tap water for one week （withdrawal phase）. Afterwards, all rats were allowed to choose their drinking source by offering two bottles, containing sugar water without and with morphine, simultaneously for two days （preference phase）. Results： While the chronic consumption of morphine led to a reduction in body weight and to morphine tolerance, the morphine-treated Wistar rats did not show any preference for the opiate-containing sugar water. Conclusion： Body weight loss and tolerance do not reveal a condition of drug craving, and current animal models should be re-evaluated regarding their potential to establish morphine addicted animals.