Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population简

Objective

A study in a Caucasian population has identified two single-nucleotide polymorphisms (SNPs) in ZNF533, one in DOCK4, and two in IMMP2L, which were all significantly associated with autism. They are located in AUTS1 and AUTS5, which have been identified as autism susceptibility loci in several genome-wide screens. The present study aimed to investigate whether ZNF533, DOCK4, and IMMP2L genes are also associated with autism in a northeastern Chinese Han population.

Methods

We performed a similar association study using families with three individuals (one autistic child and two unaffected parents). A family-based transmission disequilibrium test (TDT) was used to analyze the results.

Results

There were significant associations between autism and the two SNPs of ZNF533 gene (rs11885327: χ ²=4.5200, P=0.0335; rs1964081: χ ²=4.2610, P=0.0390) and the SNP of DOCK4 gene (rs2217262: χ ²=5.3430, P=0.0208).

Conclusions

Our data suggest that ZNF533 and DOCK4 genes are linked to a predisposition to autism in the northeastern Chinese Han population.     

浅谈构造函数法在数学解题中的应用

讨论了构造函数法在数学分析解题中的应用,针对几类具体的问题,给出了构造函数的思想和解决问题的办法。     

中国赴俄留学生毕业实习面临的问题与思考

赴俄罗斯高校学习的中国留学生毕业实习不同于普通高校,其与中俄合作办学的主要目标、为推动中俄经济贸易发展提供充足的俄语人才资源、全球化经济发展带来的对国际化人才的需求都有着紧密联系,应重视中俄合作办学中国留学生毕业实习面临的问题,积极引导其实习,为将来的就业做好充分的准备。     

加强实验教学管理 提高教学质量

随着科学技术的飞速发展,高校实验教学必须在科学理论的指导下,充分发挥现代技术手段的优势,在基础知识和基本技能的支持下进行科学探索和实践活动。文章分析实验教学的现状和问题,从加大化工学院实验室硬件和软件建设的力度、完善实验教学管理机制、科学设置实验课程、提升实验教学人员的素质水平几方面提出解决问题的对策。     

政府、行业在高职教育办学活动中的角色定位及关系分析

高职教育是以培养生产、建设、管理、服务第一线的技术应用型人才为目标,为承接世界制造中心在我国的凸现提供重要的人才保障.高职教育的内在性质和作用又决定着政府、行业在其办学活动中扮演着重要角色.文章循着这一思路,着重明晰了政府、行业在高职人才培养中的角色定位,阐明了它们与学校三者的间性关系.     

高校辅导员职业认同感培养的路径选择

近年来,高校辅导员的职业认同感依然有所缺失。其成因既有主体内在因素,也有社会环境等外部因素的影响。培养其职业认同感,不仅要加强体制机制建设,提供外部支持力量,更主要的是发挥其主体意识作用,依靠其自身努力,培养光荣感、效能感、成就感、归属感。     

Optimal design of Stewart platforms based on expanding the control bandwidth while considering the hydraulic system design

We proposed an optimal design method to expand the bandwidth for the control of large hydraulic Stewart platform. The method is based on generalized natural frequency and takes hydraulic oil into consideration. A Lagrangian formulation which considers the whole leg inertia is presented to obtain the accurate equivalent mass matrix. Using the model, the effect of leg inertia and the influence of design parameters on the generalized natural frequency are investigated. Finally, numerical examples are presented to validate and confirm the efficiency of the mathematical model. The results show that the leg inertia, especially the piston part plays an important role in the dynamics. The optimum diameter ratio of the base to the moving platform is between 2 and 3, and the optimum joint angle ratio of the base to the moving platform is about 1. The smaller joint angles and a longer leg stroke are favorable for raising system frequencies. The system oil should be preprocessed for large platforms with a requirement for good dynamic performance.     

大学生思想政治教育社会化研究

大学生思想政治教育社会化需要高校、政府、社会、家庭共同参与和配合形成合力。要通过打造校园文化、净化网络环境、校社共建,校企合作等路径,才能合力规避学生"思想回潮"现象,实现社会主流价值观念内化和自觉行为习惯外显的统一,促进大学生全面自由发展。     

高校辅导员职能的历史变迁

从20世纪50年代至今,随着高等教育的改革和发展及当代大学生发展的新需要,高校辅导员由最初单一的思想政治工作的职能发展为思想政治教育、大学生事务管理和大学生发展指导等多种职能。这一变化带来了辅导员职能结构失衡,自身角色冲突等新问题,解决这些问题的最终途径是推进辅导员工作的专业化和职业化。     

交换技术课程教学改革思路探讨

本文从激发学生兴趣、教学内容、教学理论和实践结合、引入现代教育技术观念等方面系统而深入地探讨了该课程教学的改革要领,从而为交换技术课程教学的理念和方法提供了新的思路。