Evaluation of Oxidative Stress and DNA Damage in Benign Prostatic Hyperplasia Patients and Comparison with Controls

In the present study, oxidative stress and lymphocytic DNA damage in both pre-op and post-op benign prostrate hyperplasia (BPH) patients with age >50 years was evaluated and compared with normal healthy subjects (controls- without any evidence of disease) of the same sex and age group. From December 2007 to November 2009, oxidative stress in 45 BPH patients were evaluated both before (pre-op patients) and after 7 days of surgery (post-op patients) in terms of measurements of plasma levels of (1) various anti-oxidative enzymes, (2) non-enzymatic antioxidants and (3) malondialdehyde which is a product of lipid peroxidation. The lymphocyte DNA damage was also evaluated by single cell alkaline gel electrophoresis in terms of tail length migration in these patients. These values were compared with their respective control subjects of similar sex and age group. The activities of antioxidant enzymes and the levels of antioxidant, reduced glutathione were found significantly decreased (p < 0.05) in serum samples of pre-operative group of BPH patients as compared to the controls. These altered parameters increased significantly (p < 0.05) and returned to their near normal control values, but not up to baseline values, in post operative patients i.e. after the cancer load was decreased by surgery. Lymphocytic DNA damage was found to be significantly increased in pre-op group as compared to controls and was reduced after surgery in post-op group. The present study therefore, shows significantly increased levels of oxidative stress and DNA damage in BPH patients which were reduced after removal of tumour load. Thus oxidative damage plays an important role in prostate tumourogenesis and timely management of oxidative stress can be of importance in preventing the occurrence of BPH.     

Is e-government a way to e-democracy?: A longitudinal study of the Iranian situation

Some scholars have supported e-government as a path to e-democracy, whereas others have been more cautious about the subject. In this article, we review the similarities between the concepts of e-government and e-democracy as well as evaluate e-government initiatives and e-democracy requirements in the case of Iran. We used a longitudinal study at two points in time to evaluate the path from e-government to e-democracy using two different methods: a systematic evaluation based on a checklist and a questionnaire survey. The trend of change in e-government initiatives was positive but low from 2008 to 2009, whereas the trend of change in e-democracy requirements was negative and substantial during the same period. We conclude that an emphasis on e-government as a way to e-democracy is not recommended in countries such as Iran.     

PF-BTS: A Privacy-Aware Fog-enhanced Blockchain-assisted task scheduling

In recent years, the deployment of Cloud Computing (CC) has become more popular both in research and industry applications, arising form various fields including e-health, manufacturing, logistics and social networking. This is due to the easiness of service deployment and data management, and the unlimited provision of virtual resources (VR). In simple scenarios, users/applications send computational or storage tasks to be executed in the cloud, by manually assigning those tasks to the available computational resources. In complex scenarios, such as a smart city applications, where there is a large number of tasks, VRs, or both, task scheduling is exposed as an NP-Hard problem. Consequently, it is preferred and more efficient in terms of time and effort, to use a task scheduling automation technique. As there are many automated scheduling solutions proposed, new possibilities arise with the advent of Fog Computing (FC) and Blockchain (BC) technologies. Accordingly, such automation techniques may help the quick, secure and efficient assignment of tasks to the available VRs. In this paper, we propose an Ant Colony Optimization (ACO) algorithm in a Fog-enabled Blockchain-assisted scheduling model, namely PF-BTS. The protocol and algorithms of PF-BTS exploit BC miners for generating efficient assignment of tasks to be performed in the cloud’s VRs using ACO, and award miner nodes for their contribution in generating the best schedule. In our proposal, PF-BTS further allows the fog to process, manage, and perform the tasks to enhance latency measures. While this processing and managing is taking place, the fog is enforced to respect the privacy of system components, and assure that data, location, identity, and usage information are not exposed. We evaluate and compare PF-BTS performance, with a recently proposed Blockchain-based task scheduling protocol, in a simulated environment. Our evaluation and experiments show high privacy awareness of PF-BTS, along with noticeable enhancement in execution time and network load.     

The design and development of a dyscalculia checklist based on a focus group interview

This article aims to explore the symptoms and characteristics of dyscalculia. This is a qualitative study. Five experts in the field of special education took part in a focus group interview. Each expert had more than ten years of experience in their area of expertise. To determine the content validity of the protocol, three experts in special education, language and qualitative research evaluated each of the eight items. Cohen's kappa analysis was used to assess inter-rater reliability. The findings of this study indicate that 59 items have been developed, based on six constructs in the dyscalculia checklist. The six constructs were subitising, estimating, Arabic numerals, verbal numbers, arithmetic facts and calculating processes. Following the focus group interview, a new construct emerged: math anxiety. The study implies that teachers might utilise this checklist to carry out early detection of students with dyscalculia in primary schools. This will enable appropriate intervention, resulting in significant benefits for the Ministry of Education, for educators and teachers, and for the students themselves. Although this study was based in Malaysia, the results have wider implications because dyscalculia is present everywhere.     

Student alienation at University level: Psychometric properties and relationship with student’s ICT motives

Education and Information Technologies - The purpose of this article is to develop a context-bound scale on student alienation around core problems experienced by students at the university level....     

Experiencing the community of inquiry framework using asynchronous online role-playing in computer-aided instruction class

Education and Information Technologies - This current study investigates the use of online role-playing, in an online discussion forum, in learning the community of inquiry framework – an...     

Analysis of Feasibility and Acceptability of an E-Learning Module in Anatomy

Recent advance in medical education is in correlation with the advances in information technology and thus computer-based learning is being increasingly employed. The objective of the present study was to design and evaluate an e-learning module in anatomy and assess the perceptions of students and faculty about this e-learning module. The participating students were randomized into three groups by block stratified randomization and Google groups were created for each of the three groups. The e-learning module was implemented in three sessions by rotating the three groups. Validated questionnaires were sent to faculty and participating students via Google forms to obtain feedback. The results of ANOVA showed that there was a significant difference among the groups in terms of marks obtained with conventional (F = 2.403, P = 0.103), online (F = 6.050, P = 0.005), and blended (F = 5.801, P = 0.006). Post hoc comparisons using the Tukey HSD test, about the gain of knowledge, indicated that the results were insignificant when comparing the conventional group with the online group, but were significant when comparing the blended group with the conventional and online group. The qualitative data regarding the perception of students toward e-learning were analyzed using thematic analysis. The introduction of an interactive e-learning module in anatomy was effective and well received by the students and faculty. The study showed that blended learning has a positive impact on the students' learning by improving cognitive gain and receptive perception for e-learning.     

Exposing blindspots and the hidden curriculum within counselor supervision models

Anti-racist and anti-oppressive supervision remains a burgeoning area of scholarship and research within the counselor education nomenclature. In this paper, we explore how matters of race and racism are conspicuously underemphasized in counselor training, specifically, the supervision process. We explore the hidden curriculum in counselor education supervision models. Next, we consider how a supervision model grounded in critical race theory provides a more robust framework for addressing gaps in existing supervision models through anti-racist practices.     

Entrepreneurship education in Malaysian universities

Entrepreneurship education in the strongly emerging market of Malaysia was examined throughout the country’s 20 public universities. A broad based interview process amongst multiple stakeholders profiled educational policies as well as revealing shortcomings in practice. Observers noted that students showed a preference for salaried jobs after graduation rather than setting up their own businesses, despite participation in entrepreneurship classes and programmes. Policymakers indicated that curricula had deficiencies despite their hype. Passive lectures were far more common than more interactive methods. It is suggested that if Malaysian universities are to promote entrepreneurship education in an effective way, they must address these issues.