Protection against muscle damage in competitive sports players: the effect of the immunomodulator AM3

Strenuous physical exercise of the limb muscles commonly results in damage, especially when that exercise is intense, prolonged and includes eccentric contractions. Many factors contribute to exercise-induced muscle injury and the mechanism is likely to differ with the type of exercise. Competitive sports players are highly susceptible to this type of injury. AM3 is an orally administered immunomodulator that reduces the synthesis of proinflammatory cytokines and normalizes defective cellular immune fractions. The ability of AM3 to prevent chronic muscle injury following strenuous exercise characterized by eccentric muscle contraction was evaluated in a double-blind and randomized pilot study. Fourteen professional male volleyball players from the First Division of the Spanish Volleyball League volunteered to take part. The participants were randomized to receive either placebo (n?=?7) or AM3 (n?=?7). The physical characteristics (mean±s) of the placebo group were as follows: age 25.7±2.1 years, body mass 87.2±4.1?kg, height 1.89±0.07?m, maximal oxygen uptake 65.3±4.2?ml?·?kg^?1?·?min^?1. Those of the AM3 group were as follows: age 26.1±1.9 years, body mass 85.8±6.1?kg, height 1.91±0.07?m, maximal oxygen uptake 64.6±4.5?ml?·?kg^?1?·?min^?1. All participants were evaluated for biochemical indices of muscle damage, including concentrations of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatine kinase (CK) and its MB fraction (CK-MB), myoglobin, lactate dehydrogenase, urea, creatinine and γ-glutamyltranspeptidase, both before and 30 days after treatment (over the peak of the competitive season). In the placebo group, competitive exercise (i.e. volleyball) was accompanied by significant increases in creatine kinase (494±51 to 560±53?IU?·?l^?1, P?<?0.05) and myoglobin (76.8±2.9 to 83.9±3.1?μg?·?l^?1, P?<?0.05); aspartate aminotransferase (30.8±3.0 to 31.1±2.9?IU?·?l^?1) and lactate dehydrogenase (380±31 to 376±29?IU?·?l^?1) were relatively unchanged after the 30 days maximum effort. AM3 not only inhibited these changes, it led to a decrease from baseline serum concentrations of creatine kinase (503±49 to 316±37?IU?·?l^?1, P?<?0.05) and myoglobin (80.1±3.2 to 44.1±2.6?IU?·?l^?1, P?<?0.05), as well as aspartate aminotransferase (31.1±3.3 to 26.1±2.7?IU?·?l^?1, P?<?0.05) and lactate dehydrogenase (368±34 to 310±3?IU?·?l^?1, P?<?0.05). The concentration of CK-MB was also significantly decreased from baseline with AM3 treatment (11.6±1.2 to 5.0±0.7?IU?·?l^?1, P?<?0.05), but not with placebo (11.4±1.1 to 10.8±1.4?IU?·?l^?1). In conclusion, the use of immunomodulators, such as AM3, by elite sportspersons during competition significantly reduces serum concentrations of proteins associated with muscle damage.     

Curricular change and educational quality / Cambio de plan y calidad educativa

There is no doubt that the teaching change generated by the adaptation of the former study programme to the EHEA has led to significant shifts regarding teaching loads and the organization of subjects. This paper assesses the students’ perception of the subject, the teacher and the teaching organization according to the study programme followed. For this purpose, 226 students have been assessed who have all received teaching in the same subject, with the same teacher and with the same contents, with the only variant being their study plan. An instrument developed ad hoc was applied, which comprises 18 items and assesses the students’ perceptions of the content and the perceived organization of the teaching. On the one hand, the results show the instrument to be an adequate scale that assesses teaching and organizational aspects linked to study plans in a valid and reliable way. On the other hand, it reveals that students following the new plan show more negative perceptions of organizational quality and aspects related to learning content. Moreover, these students’ marks tend to be lower compared to those achieved by students following the former plan.     

Architecture and evaluation of BRUJA, a multilingual question answering system

Given a user question, the goal of a Question Answering (QA) system is to retrieve answers rather than full documents or even best-matching passages, as most Information Retrieval systems currently do. In this paper, we present BRUJA, a QA system for the management of multilingual collections. BRUJ rkstions (English, Spanish and French). The BRUJA architecture is not formed with three monolingual QA systems but instead uses English as Interlingua to make usual QA tasks such as question classifications and answer extractions. In addition, BRUJA uses Cross Language Information Retrieval (CLIR) techniques to retrieve relevant documents from a multilingual collection. On the one hand, we have more documents to find answers from but on the other hand, we are introducing noise into the system because of translations to the Interlingua (English) and the CLIR module. The question is whether the difficulty of managing three languages is worth it or whether a monolingual QA system delivers better results. We report on in-depth experimentation and demonstrate that our multilingual QA system gets better results than its monolingual counterpart whenever it uses good translation resources and, especially, CLIR techniques that are state-of-the-art.