Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

Machine learning-enabled multiplexed microfluidic sensors

High-throughput, cost-effective, and portable devices can enhance the performance of point-of-care tests. Such devices are able to acquire images from samples at a high rate in combination with microfluidic chips in point-of-care applications. However, interpreting and analyzing the large amount of acquired data is not only a labor-intensive and time-consuming process, but also prone to the bias of the user and low accuracy. Integrating machine learning (ML) with the image acquisition capability of smartphones as well as increasing computing power could address the need for high-throughput, accurate, and automatized detection, data processing, and quantification of results. Here, ML-supported diagnostic technologies are presented. These technologies include quantification of colorimetric tests, classification of biological samples (cells and sperms), soft sensors, assay type detection, and recognition of the fluid properties. Challenges regarding the implementation of ML methods, including the required number of data points, image acquisition prerequisites, and execution of data-limited experiments are also discussed.     

Towards a Model of Intercultural Communicative Competence in Iranian EFL Context: Testing the Role of International Posture,Ideal L2 Self,L2 Self-Confidence,and Metacognitive Strategies

ABSTRACT

This study aimed to present a model of intercultural communicative competence (ICC) by incorporating international posture, motivational disposition (ideal L2 self), second language (L2) self-confidence, and metacognitive learning strategies. To this end, 150 Iranian L2 learners, selected through convenience sampling procedure, took part in the research. The findings of structural equation modelling revealed that the proposed model showed adequate fit to the data, implying that the model is appropriate in Iranian English as a foreign language (EFL) context. Also, the results indicated that learners with a high level of international posture are more likely to bridge the gap between their present and ideal selves. This was, additionally, argued that internationally oriented and ideally motivated learners become confident of their abilities to get engaged in interaction with L2 target communities. Furthermore, metacognitive learning strategies were found to be directly associated with ICC, implicating that the learners who continuously reflect on their learning and evaluate their performances are more prone to have a higher level of ICC. Finally, suggestions were offered for language teachers and policy-makers to inspire their learners to be more competent in communication with people of other cultures and languages.     

Facilitators and Barriers to Movement Integration in Elementary Classrooms: A Systematic Review

Purpose: A systematic review was conducted to identify facilitators and barriers to movement integration (MI) in elementary school classrooms. Method: Online databases (Educational Resources Information Center, Google Scholar, PsycINFO, and PubMed) served as data sources for the study. Following the PRISMA guidelines, relevant published research on MI was identified and screened for inclusion in a qualitative synthesis. Content analysis of the included articles (N = 28) was used to identify themes of MI facilitators and barriers. Facilitators and barriers were then categorized using a social-ecological framework. Results: A total of 12 themes of MI facilitators and barriers were identified and categorized into two social-ecological levels: institutional factors (e.g., administrative support, resources) and intrapersonal factors (e.g., teacher confidence, ease of implementation). Conclusion: This review can inform research and practice aimed at supporting the implementation of MI in elementary classrooms.     

Asia Arts Festival Concluded with Success An interview with Chinese Cultural Minister Cai Wu on the llth Asia Arts Festival

From August 18 to 26, 2009, the 1 lth Asia Arts Festival was successfully held in Ordos, Inner Mongolia,     

Top-down and bottom-up guidance in comprehension of schematic football diagrams

Comprehension of a narrated diagram entail complex cognitive processing as learner is challenged to extract the orally evoked information. The present experiment examined the effects of 2 different forms of attention guidance – bottom-up and top-down – on comprehension performance, cognitive load investment, and motivation to learn, using a 2 × 2 mixed design with factors “Expertise” (Expert vs. Novice) and “Condition” (no-signal, circle, segment). The results revealed an expertise reversal effect indicating that the incorporation of visual signals in diagram is effective for novice learners but partially reverses and becomes ineffective for more experienced learners (even though they invested less mental effort and reported higher level of motivation in the segmented condition). The findings suggested that the effectiveness of instructional guidance depends heavily on levels of prior knowledge.     

China International Piano Competition to be Held in Xiamen

The 6th China International Piano Competition (CIPC), organized by the Ministry of Culture of China (MOC) and presented by Xiamen People’s Municipal Government, will be held in Xiamen from November 16 to 26, 2013. CIPC, a triennial event, is one of     

A New Chapter for the Ancient Silk Road 2012 Year of Chinese Culture in Turkey

<正>Opened on December 12, 2011 and after 365 days, the 2012 Year of Chinese Culture in Turkey is closed as a full success on December 04, 2012. Various events during the Year are like a strong "Chinese wind"blowing across dozens of Turkish cities. According to statistics from the Culture Section of the Embassy of China in Turkey, during the Year,     

13th China Wuqiao International Acrobatic Festival Concluded with Great Success

From October 22 to 30, 2011, the 13th China Wuqiao Acrobatic Festival was held in Shijiazhuang, north China’s Hebei province.Co-organized by the Ministry of Culture of China and Hebei People’s Provincial Government, this biennial event featured the theme of "developing acrobatic art, facilitating international exchanges,promoting economic and social development,and enriching people’s cultural life". This year,the festival attracted more than 200 acrobats from 27 circus companies from 17 countries and regions around the world, including Russia,Canada, USA, DPRK, Australia and France, who