Biochemical studies to confirm a missed case of multiple myeloma in a seventy year old male

Routine investigations of a 70 year old male led to provisional diagnosis of anemia. However further investigations suggested the possibilities of carcinoma of stomach associated with pernicious anemia, multiple myeloma and megaloblastic anemia. Finally serum protein electrophoresis supported by the clinical suspicion confirmed multiple myeloma.     

Fetal lead exposure: Encephalopathy in a child

It is well known that lead exposure in the early period of pre pregnancy and antenatal life leads to serious health complications. In this case report, a five month old child who was suffering from encephalopathy was finally confirmed a victim of lead exposure, the source being the environment and the family. We report this case with complete clinical investigation including blood lead analysis. This case report highlights the various ways in which lead may accumulate in the body. It is also aimed at increasing awareness regarding the pathogenesis and clinical manifestations of lead toxicity. The literature survey done reveals that this is the youngest age at which lead toxicity has been documented in India.     

Haemoglobin electrophoresis in diagnosing a case of sickle cell anaemia associated with β-thalassemia

Alkaline haemoglobin electrophoresis is a useful tool in diagnosing β-thalassemia and sickle-cell anaemia. In this report, using this simple technique, β-thalassemia associated with sickle-cell anaemia is diagnosed. This is the first case we have diagnosed in our laboratory using agarose gel electrophoresis.     

Noetica: a tool for semantic data modelling

Noetica is a tool for structuring knowledge about concepts and the relationships between them. It differs from typical information systems in that the knowledge it represents is abstract, highly connected and includes meta-knowledge (knowledge about knowledge). Noetica represents knowledge using a strongly-typed semantic network. By providing a rich type system it is possible to represent conceptual information using formalised structures. A class hierarchy provides a basic classification for all objects. This allows for a consistency of representation that is not often found in “free” semantic networks and gives the ability to easily extend a knowledge model while retaining its semantics. We also provide visualisation and query tools for this data model. Visualisation can be used to explore complete sets of link-classes, show paths while navigating through the database, or visualise the results of queries. Noetica supports goal-directed queries (a series of user-supplied goals that the system attempts to satisfy in sequence) and path-finding queries (where the system find relationships between objects in the database by following links).     

The changing scenario in diagnosing prostate cancer

Fifty patients were evaluated for serum total PSA (Prostate Specific Antigen), free PSA (f-PSA), free/total PSA ratio (f/t PSA ratio) and TPS^TM (Tissue Polypeptide Specific Antigen). Fifty patients were clinically evaluated and categorized into BPH (benign prostatic hypertrophy) and CaP (carcinoma prostate) with twenty-five in each category before the serological examination. Serum total PSA concentration is elevated in 80% of BPH cases while it was elevated in all cases of CaP. With total PSA>10ng/mL, f/t PSA ratio was not applicable. For TPS^TM, a cell proliferation marker these values were 32% and 92% respectively. The advanced cases of CaP were reflected by the pronounced elevations of PSA and TPS^tM while f/t PSA ratio was much below the cut-off limit (cut-off limit=0.14). The data suggest that whentotal PSA concentration <10ng/mL, f/t PSA ratio plays a very important role in discriminating BPH and CaP. However, TPS^TM can be used as a valuable adjunct in diagnosis and follow-up of prostate cancer patients, especially in differentiating benign from malignant cases.     

Tyrosinase activity in photosensitive individuals inin-vitro study

A reddish glow localized within the iris was observed in the photographs of some individuals in the dark using an electric-arc flash. On repeated exposure and reprints of the same individuals to photography under similar conditions, the red glow persisted. Studies were under taken to analyze thein vitro effect of cupric ions on the activity of serum tyrosinase. A significant increase in the activity of tyrosinase was observed in the affected individuals as compared to the controls when cupric ion was supplementedin vitro. Studies also confirmed the inhibitory effect of benzoic acid on serum tyrosinase activityin vitro. Our preliminary studies have shown a significant decrease (p<0.001) in tyrosinase activity in the serum of the photosensitive individuals compared to controls which is consistent with the observed red glow on the photographic prints and reprints.     

Semiconductor Research Corporation: A Case Study in Cooperative Innovation Partnerships

In the study of innovation institutions, it is important to consider how different institutional models can affect a research organization in conducting or funding successful work. As an industry collaborative, Semiconductor Research Corporation (SRC) provides an example of a privately funded institution that leverages the inputs of several member companies, along with federal funding, to accomplish innovation in its mission area. SRC has several component programs, all attempting to find innovative solutions to semiconductor problems, but on different time scales, and in different technology areas. But how does SRC use its resources to ensure these goals? Through data gathered from semi-structured qualitative interviews and SRC documentation, this paper addresses that question. SRC has found a way to leverage industry money to motivate and develop a robust field of university research for over 30 years. SRC uses several mechanisms for maintaining an application focused, member-centered decision process, institutional flexibility, and strong ties between industry contributors and university researchers. SRC has continued to keep its members satisfied by training thousands of graduate students for employment in their member companies, by focusing on precompetitive research that addresses industry requirements, and doing so in a manner that operates leanly, with low overhead to its funders. Given these successes, we identify aspects of SRC operations, such as a focus on its member company needs, frequent interactions between funders and researchers, flexible funding mechanisms, and focus on workforce development, that may be diffusible to innovation institutions, including federal research efforts.