Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Mediated absent presence in forced displacement

ABSTRACT

For many forcefully displaced people worldwide, notions around one’s sense of “home” and “place” in the world are perpetually unsettled. This article explores how digital technologies interact with embodied, material experiences within the geographical location refugees are residing in. Empirical examples from ethnographic research conducted among Iraqi urban refugees, living in prolonged uncertainty in Jordan, shows how situated experiences of legal, material, and social uncertainty reinforce particular mediated socialities. Pivotal studies have shown how digital connections engender virtual home-making practices and a wide variety of connected presences. This study points to the other side of the same coin: the cultivation of “absent presence.” “Absent presence” refers to feelings—the ambivalence that experiences of prolonged displacement bring about—but also to active disengagement and affective tactics in response. These engender a further separation from the physical world where forced migrants are not deemed welcome.     

下一代图书馆系统平台的实践与思考

[目的/意义]大数据与人工智能等技术为图书馆智慧服务带来机遇与挑战，图书馆新系统平台建设刻不容缓。旨在探讨下一代图书馆系统平台发展现状及对策，为建设一流高校智慧图书馆提供实践案例与参考依据。[方法/过程]梳理图书馆系统平台发展脉络，在盘点现有的国内外下一代图书馆系统平台的研究与实践的基础上，以南京大学为例，探索图书馆新系统平台的建设方案。[结果/结论]智慧图书馆将通过建设一体化电子资源管理平台并打造NLSP，提升图书馆资源管控和知识服务水平，构建开放共享的智慧图书馆服务体系。     

大学经典推荐书目的遴选标准与发展特点

[目的/意义] 经典阅读处于学生通识教育的核心环节，大学经典推荐书目在"读什么""怎么读"的核心教育环节发挥着重要作用。分析和确立大学经典推荐书目的遴选标准，探究其发展特点，对于优化经典书目编制、推动经典阅读，具有十分重要的意义。[方法/过程] 通过网络调研和电话访谈梳理部分"双一流"高校的官方经典推荐书目，分析我国高校经典推荐书目的产生过程与背景。[结果/结论] 大学经典推荐书目在遴选上重视中国传统经典，也注重借鉴西方经典；人文社会科学经典与自然科学经典遴选相对均衡；发掘元典书目新生，重视充实有价值的影响书目。同时，在阅读推广实践中，呈现出尊重阅读主体、重视首因效应发挥、丰富创新推介载体，以及差异化、层次化、定制化的发展特点，体现出高校党政领导的重视和图书馆的主动作为。     

学习团队协作信息搜索的共享心智模型研究

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。     

Olfaction and emotion: The quest for olfactory restoration in two speech communities

ABSTRACT

Olfaction has been described as one of the least studied of the senses. This has certainly proven true in Communication. This project applies Ethnography of Communication and Cultural Discourse Analysis to examine the role that olfaction plays in the cultural meaning systems of two speech communities: residents surrounding the Gowanus Canal and bereaved parents. The cultural hub used to explore the cultural significance of olfaction in both speech communities is feeling. The analyses illustrate how emotions are tied to associated sensations and further become activated through radiants of dwelling, relating and acting. The analysis also shows how olfaction may serve to unify and separate members of a community. The significance of this research encourages stretching the boundaries of communication studies by examining the less studied physical senses and the boundaries of Cultural Discourse Analysis by providing distinctions that others can incorporate when examining feelings.     

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.     

Deep teaching in a college STEM classroom

Cultural Studies of Science Education - The retention of underrepresented students remains a significant challenge in the STEM (Science, Technology, Engineering and Math) disciplines. A broad range...     

What motivates enrolment in programming MOOCs?

Learners who enrol in massive open online courses (MOOCs) have different backgrounds and tend to have different motivations than learners in traditional courses. Based on value-expectancy theory, an instrument was developed to measure motivation for enrolling in a programming MOOC. A study with 1229 adult participants in Estonian-language programming course “About Programming” was conducted to validate the instrument. Results of confirmatory factor analysis validated the 7-factor scale named factors influencing enrolment in MOOC (FIEM). FIEM comprises three factors of expectancies, three factors of values and one factor of social influence. The highest and lowest rated motivational factors influencing enrolment in programming MOOC are discussed in the paper. Interest in and expectations for the course, personal suitability of distance learning and suitability for family and work are the highest-rated motivational factors for those who enrol in MOOC. Usefulness related to own children, social influence and usefulness to related to certification were the lowest rated. The results of this study can be useful for designers of programming MOOCs and the developed scale might be used in future studies.