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461.
Alcohol induced effects on kidney 总被引:1,自引:1,他引:0
After administration ethanol and its metabolites go through kidneys and are excreted into urine, and its content in the urine
is higher than that of the blood and the liver. Chronic ethanol administration decreases the renal tubular reabsorption and
reduces renal function. Multiple functional abnormalities of renal tubules may be associated with ethanol-induced changes
in membrane composition and lipid peroxidation. The vulnerability of the kidney to oxidative damage has been partly attributed
to its high content of long-chain polyunsaturated fatty acids. Renal ultra structural abnormalities due to ethanol exposure
may be important in the genesis of functional disturbances. Increased oxidative stress and endothelial dysfunction with their
complex interrelationships are relevant aspects of atherogenesis in chronic renal failure. Antioxidants, particularly polyphenols
are expected to decrease the vulnerability of the kidney to oxidative challenges. 相似文献
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Ananth N. Rao Rajesh B. Iyer J. Kavitha Minakshi Koch Kumar V. Suresh 《Indian journal of clinical biochemistry : IJCB》2008,23(4):407-409
Defects in biotin metabolism are mainly associated with either the enzyme Biotinidase or Holocarboxylase synthetase. Defects
in either enzymes depletes biotin utilization by the cells. Holocarboxylase synthetase deficiency is an inherited disorder
in which the body is unable to use the vitamin biotin effectively. This condition is inherited in an autosomal recessive pattern.
We present a case of a 9 year old girl with atypical symptomology as a case holocarboxylase synthetase deficiency, who demonstrated
an increased excretion of propionic and methyl malonic acids, with her biotinidase activity being normal. She demonstrated
remarkable improvement on biotin supplementation. 相似文献
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Bhaskar S Veena Sharmila Upadhya Satish Kumar Adiga Kumar N Pratap 《Indian journal of clinical biochemistry : IJCB》2008,23(2):186-190
The objective of the study was to estimate the serum concentrations of oxidative stress markers-lipid hydroperoxide (MDA-Malondialdehyde),
lactate dehydrogenase (LDH), nitrite; and ferric reducing antioxidant power (FRAP) — a measure of total antioxidant capacity
in serum. Serum nitrite levels were high in fertile women than in infertile women (p<0.001), whereas MDA was high in infertile
women than in fertile group (p<0.018). On classifying the entire group of women with infertility based on the etiology, serum
MDA and LDH levels were higher in women with infertility due to unexplained factor than in women with other causes contributing
to infertility compared to controls (p<0.001, p<0.02). A positive correlation among serum prolactin and nitrite suggested
that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Serum FRAP levels showed no significant
difference in the groups studied. Lipid peroxidation was high in women with unexplained infertility which may be due to hyperprolactinemia. 相似文献
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This article introduces the Kumar and Chubin-edited collection, Science, Technology, and Society: A Sourcebook on Research and Practice (Kluwer Academic/Plenum Publishing, New York). STS, a hybrid area of scholarship focuses on science-technology-society interactions, draws on the intellectual resources of scientists, educators, engineers, social scientists, and philosophers inside and outside academe. A dozen chapters examine STS trends, curriculum, teaching, learning, mentoring, advocacy, public policy, and issues for further research. 相似文献