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排序方式: 共有611条查询结果,搜索用时 31 毫秒
471.
Devendra K. Rai Prashant Kumar Rai Aradhna Gupta Geeta Watal Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201
Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides
such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein,
total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses
of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease
in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats
exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum
lipids in rat. 相似文献
472.
Vishnu Kumar A. K. Khanna M. M. Khan Ranjana Singh Sushma Singh Ramesh Chander Farzana Mahdi J. K. Saxena Shweta Saxena V. K. Singh R. K. Singh 《Indian journal of clinical biochemistry : IJCB》2009,24(1):65-69
The present study was carried out to evaluate the hypoglycemic, lipid lowering and antioxidant activities in root extract
of Anthocephalus indicus (A indicus) in alloxan inducd diabetic rats. Oral administration of ethanol extract of root (500mg/
kg body weight) for 21 days resulted in significant decrease in the levels of blood glucose, triglycerides, total cholesterol,
phospholipid and free fatty acids. Furthermore, the root extract (100–400μg) inhibited the generation of superoxide anions
and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The result of the present study demonstrated hypoglycemic,
lipid lowering and antioxidant activities in root extract of A indicus, which could help in prevention of diabetic dyslipidemia
and related diseases. 相似文献
473.
Role of oxidative stress while controlling iron deficiency anemia during pregnancy - Indian scenario
Neeta Kumar Nomita Chandhiok Balwan S. Dhillon Pratik Kumar 《Indian journal of clinical biochemistry : IJCB》2009,24(1):5-14
Iron Deficiency anemia ranks 9th among 26 diseases with highest burden. Asia bears 71% of this global burden. Adverse maternal and birth outcome associated
with hemoglobin status renders the issue worth attention. Indian scenario has worsened over the period despite continuous
international and national efforts. This indicates some lacunae in the approach and strategies applied. Various reports state
that even with maximum effort to increase outreach and monitoring for adherence to Iron schedule, consumer’s compliance remains
abysmally low. Recent studies has pointed out biological basis of side effects (gastrointestinal complains and systemic events)
as raised oxidative stress for which iron is the key catalyst. Up till now the only target of research has been to raise hemoglobin
of pregnant women above 11gm/dl. With the reports of pregnancy specific morbidities i.e. hemorrhage and septicemia with low
hemoglobin, eclampsia, small for gestation age, gestational diabetes with higher ranges of hemoglobin, alarm is raised to
define optimum range. Use of oxidative stress as biochemical marker with different doses and schedules has been defined because
India lack information for its own population upon oxidative stress status when iron is supplemented as per current guidelines.
Studies done in India and abroad have defined that too much and too less, both may raise oxidative stress and studies of this
sort may provide biochemical scale for optimization. This review therefore has evaluated currently available Indian research
and reports to understand the need of future research area. Important findings from other countries have been incorporated
for comparison. 相似文献
474.
G. Sharmila Banu G. Kumar A. G. Murugesan 《Indian journal of clinical biochemistry : IJCB》2009,24(4):414-418
The aim of this study was to investigate the ethanolic leaf extract of Trianthema portulacastrum L. (Family: Aizoaceae) on
aflatoxin induced hepatic damage in rats. Aflatoxin intoxication in rats significantly (p < 0.001) elevated the levels of
serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP),
and total bilirubin, which indicated acute hepatocellular damage and biliary obstruction. Ethanolic leaf extract of T. portulacastrum
showed dose dependent decrease in the levels of SGPT, SGOT, ALP and total bilirubin. Minimum effective dose of extract was
found to be 100 mg/kg body weight. Results obtained from histopathological studies also supported hepatoprotective activity
against aflatoxin-induced hepatotoxicity. Thus the study demonstrates that T. portulacastrum possess antihepatotoxic effect
against aflatoxin. 相似文献
475.
476.
477.
We have studied the effect of flap parameters on fluid rectification in a microfluidic diode. We use Navier-Stokes equations and arbitrary Lagrangian-Eulerian formulation to obtain dynamics of fluid flow and motion of the flap. The flap opens during forward flow and seals against a stopper during reverse flow. This allows flow in the forward direction and prevents it in the reverse direction. The rectifier is fluidic analog to a semiconductor diode in function because it rectifies fluid flow. Velocity-pressure (V-P) curves analog to the current-voltage (I-V) curves of the electronic diode has been obtained. The effect of the flap parameters, such as length, thickness, and Young's modulus has been found out. The transient response of the flap and fluid flow under oscillating pressure driven flow has also been obtained. 相似文献
478.
N. Krishnamurthy K. Arumugasamy U. Anand C. V. Anand V. Aruna G. Venu R. Gayathri 《Indian journal of clinical biochemistry : IJCB》2010,25(1):43-46
Plasma cystatin C is an emerging parameter to assess kidney function. Its utility in assessing the adequacy of hemodialysis
in patients with end-stage-renal disease has however not been established with certainty. This study was therefore carried
out to assess the usefulness of serum cystatin C estimation in patients undergoing low flux membrane hemodialysis. Serum creatinine
and cystatin C were estimated in 20 patients before and after undergoing hemodialysis. The mean serum creatinine decreased
from a pre-dialysis value of 7.72 mg/dL to a post-dialysis value of 2.90 mg/dL. On the contrary, the mean serum cystatin C
levels were found to increase from a pre-dialysis value of 5.97 mg/L to a post-dialysis value of 8.25 mg/L. Therefore, serum
cystatin C cannot be used to monitor dialysis adequacy. It however, serves as a surrogate marker of the inadequacy of low
flux membrane bicarbonate hemodialysis in clearing low molecular weight proteins from the circulation. 相似文献
479.
Role of plasma amino acids and gaba in alcoholic and non-alcoholic fatty liver disease-a pilot study
S. Mukherjee K. Vaidyanathan D. M. Vasudevan Subir Kumar Das 《Indian journal of clinical biochemistry : IJCB》2010,25(1):37-42
Alcohol appears to affect brain function, primarily by interfering with the action of gamma-aminobutyric acid (GABA) and other
neurotransmitters. As alcohol is mainly metabolized in the liver, therefore we undertook this pilot study to monitor the patterns
of changes in plasma amino-acid concentrations due to alcoholic and nonalcohol fatty liver disease and their relation with
plasma GABA level. Plasma amino-acid concentrations were measured in 25 alcoholic liver disease (ALD) patients, 18 non-alcoholic
fatty liver disease (NAFLD) patients, and 24 age and sex matched control subjects by HPLC. GABA concentration was elevated,
while isoleucine and leucine levels reduced significantly in ALD patients compared to the control subjects. Methionine and
phenylalanine levels elevated and valine content reduced significantly in ALD patients compared to other two groups, and GABA
level was significantly correlated with methionine and phenylalanine. Plasma concentration of lysine was significantly reduced
in both groups of liver disease patients compared to the control group, but was not correlated with GABA level. Glycine and
tyrosine levels reduced significantly in NAFLD patients compared to other two groups and were significantly correlated with
GABA. Interestingly, though amino acids such as alanine, histidine, proline and serine were not affected by liver diseases,
but were significantly correlated with GABA level. This pilot study indicated that alcoholic liver disease presented a more
deranged plasma amino acid pattern than nonalcoholic, and the amino acid imbalances. More studies are necessary to identify
the role of any particular amino acid on brain function and on neurotransmitter(s). 相似文献
480.
Ratan Kumar 《Indian journal of clinical biochemistry : IJCB》1998,13(2):87-91
Effect of L-carnitine supplementation on myocardial free fatty acid oxidation,in vitro, in offsprings born of hypothyroid and hyperthyroid mothers was studied in rats. L-carnitine supplementation stimulated myocardial
fatty acid oxidation during gestational period in offspring born of control and hyperthyroid mothers. In contrast L-carnitine
supplementation induced stimulation in myocardial fatty acid oxidation was very less in fetuses born of hypothyroid mothers.
However, in neonates born of hypothyroid mothers L-carnitine stimulated myocardial fatty acid oxidation to a great extent.
The results suggested that during maternal hypothyroidism low availability of thyroid hormones to fetuses through maternal
circulation and availability of less carnitine to neonates due to hypolactation might be responsible for decreased myocardial
free fatty acid utilization. In neonates born of hypothyroid mothers and with cardiac energy insufficiency parenteral carnitine
supplementation might be of great help to prevent mortality and morbidity of such offsprings. 相似文献