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411.
Bhawna M. Singh B. Goswami V. Mallika 《Indian journal of clinical biochemistry : IJCB》2010,25(2):141-145
The effect of thyroid status on insulin sensitivity is of great interest but despite various studies there is conflicting
data on this subject. The study group comprised of 25 female subjects each with subclinical hypothyroidism, overt hypothyroidism
and euthyroid controls. Serum samples of all the patients were assayed for thyroid profile, Insulin and lipid profile. Homeostasis
model of assessment (HOMA-IR) was employed to assess the level of insulin resistance. Patients with hypothyroidism demonstrated
insulin resistance and dyslipidemia as observed by the higher HOMA-IR and cholesterol and triglyceride levels respectively
as compared to the controls. A significantly positive correlation between TSH and HOMA-IR level was also observed in the hypothyroidism
group. Thyroid dysfunction leads to alterations in glucose and lipid metabolism which is an important risk factor for cardiovascular
diseases. The dyslipidemia and insulin resistance should be managed aggressively to reduce the impending risk. 相似文献
412.
Singh B Panda S Nanda R Pati S Mangaraj M Sahu PK Mohapatra PC 《Indian journal of clinical biochemistry : IJCB》2010,25(4):367-370
Insulin resistance and the resultant hyperinsulinemia exacerbate the reproductive abnormalities of Polycystic Ovarian Syndrome
by increasing ovarian androgen productions and decreasing serum sex hormone binding globulin. The present study was conducted
to estimate serum insulin and testosterone level in 44 PCOS cases and 32 control patients. Simultaneously the role of metformin
(an insulin sensitizing agent) in modulating insulin resistance and serum androgen level was also analyzed. A significant
rise in serum insulin and testosterone (P < 0.001) was observed in cases in comparison to control. Fasting Plasma Glucose to insulin ratio, a marker of insulin resistance
revealed a significant fall in PCOS group. Follow up of cases with metformin for 3 months revealed a significant fall in serum
insulin (P < 0.05) with improvement in insulin resistance along with a nonsignificant fall in testosterone level. Serum insulin registered
a significant positive correlation (P < 0.05) with serum testosterone revealing its etiological association. Thus administration of drugs ameliorating insulin
levels is expected to provide new therapeutic modality for PCOS. 相似文献
413.
M. Sachidhanandam S. N. Singh A. K. Salhan Uday Sankar Ray 《Indian journal of clinical biochemistry : IJCB》2010,25(2):153-157
The study involved three ethnic groups of India; Rajputs, Gorkhas and South-Indians. Each group consisted of ∼40 healthy,
male soldiers between 20–50 years. The reference ranges for cortisol, testosterone, prolactin, arginine vasopressin and proAtrial
natriuretic peptide1–98 were determined using Enzyme-Immunoassay (EIA) while plasma levels of thyroid-stimulating hormone, triiodothyronine, free-triiodothyronine,
thyroxine and freethyroxine were measured using Enzyme-linked immunosorbent assay (ELISA). The results indicated that plasma
hormone concentrations were within physiological range and inter-ethnic differences were most prominent between north- (Rajputs
and Gorkhas) and south- Indians. In comparison to Radioimmunoassay, the EIA method for prolactin, thyroid-stimulating hormone,
free-thyroxine gave higher values while the ELISA method for triiodothyronine, free-triiodothyronine, and thyroxine gave lower
values. These differences are due to differences in assay standards and design. 相似文献
414.
R. Vaishya Sarika Arora B. Singh V. Mallika 《Indian journal of clinical biochemistry : IJCB》2010,25(1):64-66
The negative interference of bilirubin on serum creatinine determined by the kinetic alkaline picrate (Jaffe) reaction is
the unresolved problem. Though high performance liquid chromatography and gas chromatography with mass spectroscopy have been
proposed to be gold standards for creatinine estimation but they are not readily available in most of the clinical chemistry
laboratories due to economic and technical constraints. Most of the present day analyzers use Jaffe’s kinetic method without
deproteinization. Though enzymatic methods are now routinely used as most accurate method but they are not acceptable due
to cost constraints. Hence this study was planned to find out a possible solution to the problem of bilirubin interference
by a minor modification in the commonly used Jaffe method so that it is amenable for use on the currently used analyzers. 相似文献
415.
416.
Basil R. Singh 《Educational studies》1998,24(2):165-182
Liberals, from Mill to Rawls see personal autonomy as paramount in civil society. They see human dignity to consist essentially in personal autonomy, that is, ‘in the ability of each person to determine for himself or herself a view of the good life’ (Taylor, C. (1992) p. 27). Multiculturalism and “The Politics of Recognition” p. 57 (Princeton, Princeton University Press). This emphasis on personal autonomy underlies much of liberal emphasis on freedom of conscience, justice, rights and fairness. Its core thesis is that a just society seeks not to promote any particular view of the good life, but enables its citizens to pursue their own ends consistent with a similar liberty for all others. Yet, when some citizens in America attempted to pursue their own view of the good life, they came up against head‐on conflict with the liberal state. These groups saw civic education with its emphasis on individual choice, on reflecting and weighing of alternative viewpoints and on personal autonomy, as threatening to their way of life and to their fundamental religious beliefs, and consequently they challenged the state in the courts. What ensued raised profound educational problems for educating children, parental rights, and the right of the State in a liberal democratic society, which are discussed in this paper. 相似文献
417.
The use of ultrasound for promoting chemical reactions is described. 相似文献
418.
419.
420.
Singh TD Barbhuiya MA Gupta S Shrivastav BR Jalaj V Agarwal N Tiwari PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):146-153
We have studied the expression of lactate dehydrogenase and its isoforms in gall bladder cancer, cholelithiasis and chronic
cholecystitis. Quantitative and qualitative assays of lactate dehydrogenase and its various isoforms were carried out in the
blood sera of patients and healthy controls along with parallel estimation of various liver function test enzymes. Statistical
analysis was done using the software Graph Pad Prism. Significantly high expression of lactate dehydrogenase along with alkaline
phosphatase and total bilirubin (P ≤ 0.05) was observed in all the three clinical conditions as compared to controls. LDH showed an increasing trend from stage
I to stage IV of GBC indicating a significant positive association with the disease progression. The levels of LDH 3 and 4
isoforms appeared significantly more elevated in GBC than cholelithiasis or chronic cholecystitis. We suggest that a careful
estimation of total LDH and its isoforms 3 and 4 alone or along with alkaline phosphatase and total bilirubin during different
clinical stages, like chronic cholecystitis, cholelithiasis and GBC, may prove to be a potentially useful biomarker in the
prognostic management of gall bladder diseases, specifically GBC. 相似文献