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181.
Karthiga Panneerselvam Martin E. Lynge Camilla Frich Riber Sofia Mena-Hernando Anton A. A. Smith Kenneth N. Goldie Alexander N. Zelikin Brigitte St?dler 《Biomicrofluidics》2015,9(5)
Recently, the combination of lipids and block copolymers has become an alternative to liposomes and polymersomes as nano-sized drug carriers. We synthesize novel block copolymers consisting of poly(cholesteryl acrylate) as the hydrophobic core and poly(N-isopropylacrylamide) (PNIPAAm) as the hydrophilic extensions. Their successful phospholipid-assisted assembly into vesicles is demonstrated using the evaporation-hydration method. The preserved thermo-responsive property of the lipid-polymer hybrids is shown by a temperature dependent adsorption behaviour of the vesicles to poly(l lysine) coated surfaces. As expected, the vesicle adsorption is found to be higher at elevated temperatures. The cellular uptake efficiency of hybrids is assessed using macrophages with applied shear stress. The amount of adhering macrophages is affected by the time and level of applied shear stress. Further, it is found that shorter PNIPAAm extensions lead to higher uptake of the assemblies by the macrophages with applied shear stress. No inherent cytotoxicity is observed at the tested conditions. Taken together, this first example of responsive lipid-polymer hybrids, and their positive biological evaluation makes them promising nano-sized drug carrier candidates. 相似文献
182.
Zhenwei Liu Ali Saberi Anton A. Stoorvogel Donya Nojavanzadeh 《Journal of The Franklin Institute》2021,358(9):4864-4882
In this paper, we design scale-free collaborative protocols for state and regulated state synchronization of homogeneous multi-agent systems (MAS) with arbitrary fast convergence. The protocol design solely depends on the knowledge of the agents’ model and does not require any information about the communication network and the number of agents. Moreover, our protocols can achieve synchronization with any desired convergence rate by simply tuning a design parameter. 相似文献
183.
de Koning Bjrn B. Boonen Anton J. H. Jongerling Joran van Wesel Floryt van der Schoot Menno 《Educational Studies in Mathematics》2022,111(1):29-45
Educational Studies in Mathematics - Drawing bar diagrams has been shown to improve performance on mathematical word problems wherein the relational keyword is consistent with the required... 相似文献
184.
Anton Franks Pat Thomson Chris Hall Ken Jones 《Changing English: An International Journal of English Teaching》2014,21(2):171-181
What are possible overlaps between arts practice and school pedagogy? How is teacher subjectivity and pedagogy affected when teachers engage with arts practice, in particular, theatre practices? We draw on research conducted into the Learning Performance Network (LPN), a project that involved school teachers working with the Royal Shakespeare Company and the University of Warwick. The aim of the commissioned research was to look at the effects on teacher development, focusing on the active rehearsal room pedagogic techniques and ensemble methods of exploring Shakespearean text and performance. The practices of working as an ensemble through rehearsal room pedagogy were central to the LPN. Our interest is in looking for possible shifts in teachers’ subjectivity, their self-perception. What affordances, limitations, accommodations and tensions are experienced by the teachers in transposing work from the rehearsal room to the classroom? We draw on a range of cultural theories that provide complementary perspectives on aspects of subjectivity; these include Vygotskian approaches to the psychology of art and acting. Raymond Williams’s work on the ‘dramatized society’ and Jacques Rancière’s work on spectatorship and pedagogy. Data in the form of excerpts from field notes, taken in an introductory workshop where teachers worked with theatre practitioners, and from transcribed interviews with participants in the project are used to provide evidence of shifts in perspective, self-perception and pedagogic practice. 相似文献