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41.
Amar B. Singh J. P. Chaturvedi T. Narender Arvind K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2008,23(4):391-393
Peganum harmala L. (Zygophyllaceae) is a traditional medicine used for the treatment of variety of human ailments, including
antidepression, hallucination, antileishmaniasis etc. We report for first time the hypoglycemic activity of the ethanolic
extract of this plant at two dose levels of 150 and 250mg/kg bw in sucrose challenged normal as well as in rats with streptozotocin
induced diabetes. The oral administration of ethanolic extract causes maximum fall of blood glucose level to 22.9% (p<0.05)
and 29.4% (p<0.01) respectively with the two doses in normal and 30.3% (p<0.01) and 48.4% (p<0.001) in diabetic rats. The
standard drug metformin treated group showed 28.0% (p<0.01) and 45.5% (p<0.001) respectively in normal and diabetic rats.
The above results show that the ethanolic extract of P. harmala is as effective as metformin in reducing the blood glucose
levels of normoglycemic and streptozotocin-induced diabetic rats. 相似文献
42.
S. Vasisht R. Gulati R. Narang N. Srivastava L. M. Srivastava S. C. Manchanda D. P. Agarwal 《Indian journal of clinical biochemistry : IJCB》2002,17(1):99-107
An elevated level of plasma homocysteine, sulfur containing amino acid generated through demethylation of methionine has been
widely accepted as a risk factor for cardiovascular disease (CVD). The increase can result from genetic and/or nutrient related
disturbances in the remethylation or transsulfuration pathways for homocysteine metabolism. A common mutation (C677T) in the
gene encoding for the enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) or deficiency of the B vitamins namely folic
acid, B12, B6 can lead to hyperhomocysteinemia.
In the present study, we have investigated the incidence of the (C677T) MTHFR polymorphism in the North Indian males. 141
angiographically proven coronary artery disease (CAD) patients and 55 age and sex matched healthy volunteers were examined
for the association between MTHFR gene polymorphism and CAD. The MTHFR genotyping was performed using polymerase chain reaction
(PCR) followed by restriction-isotyping with Hinf 1 endonuclease. A trend for higher ‘T’ allele frequency (0.19) was observed
in patients than in controls (0.16). However no significant association was found between C677T mutation and CAD severity.
The lack of statistical significance could be due to the small sample size studied. Hence a larger study including various
ethnic groups is warranted. 相似文献
43.
Janardan Krishna Yadav Deepika Chandra Verma Srinivas Jangirala Shashi Kant Srivastava 《The Journal of High Technology Management Research》2021,32(1):100404
The concept of smart tourism remains fuzzy when it comes to practice because of the lack of clarity on the roles and responsibilities of stakeholders in addition to complex institutional ecosystem that exist within the tourism industry. Further, trust and safety of the data generated due to the advancement of smart tourism in varied institutional arrangements pose huge challenges. Extant literature proposes that the application of decentralized ledger promises possible solutions to most of these problems due to the inherent features of the Blockchain technology. This suggestion raises two practical questions. First, does the sophisticated additional layer adds complexity to its practical application? Second, will the suggested solutions really lead to a win-win for all the stakeholders involved? In this study, we use Ostrom's action arena to examine the exchanges (information, contractual and monetary) between various stakeholders in a BCT enabled smart tourism of a Blockchain enabled tourism industry to answer these two questions. 相似文献
44.
V. K. Gupta V. Mallika Yashika Gupta D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》1992,7(1):3-10
Oxygen derived free radicals have been implicated in a number of clinical disorders including atherosclerosis (1), ischemic
heart disease (IHD) (2), post ischemic reperfusion injury (3) and respiratory distress syndrome (4). These radical are generated
by sequential reduction of molecular oxygen; the primary product being superoxide anion (O2
.−) which is subsequently reduced to hydrogen peroxide (H2O2), hydroxy1 radical (OH.) and singlet oxygen (1O2). However the evidence for ODFR induced cell damage in various clinical disorders is still debated and rests largely on free
radical scavenging studies, through electron paramagnetic resonance spectroscopic (EPRS) studies have provided direct evidence
for ODFR generation following coronary artery ligation (5).
By definition, a free radical is an atom, ion or molecule with one or more unpaired electrons (the presence of unpaired electron
in a free radical being represented by a superscribed bold dot-R.) and may be formed as a result of homolytic fission of a covalent bond or by electron transfer reactions, and may have cationic
(NH3
+), anionic (O2
.−) or neutral (NO) characteristics. The most important in vivo source for these radical species have been found to be univalent
biochemical redox reactions involving oxygen. (a) A:B→A.+B. (b) A:+B→A.+B. 相似文献
45.
Vibha Singh Neena Srivastava Priyanka Srivastava Rama Devi Mittal 《Indian journal of clinical biochemistry : IJCB》2013,28(3):259-264
Chemokine are small, inducible pro-inflammatory cytokines involved in many biological processes, such as migration of leukocytes, atherosclerosis, angiogenesis, tumor growth, and metastasis. Chemokine are also known to influence tumor cell’s activity. Specifically, tumor cells express chemokine receptors in a non random manner suggesting a role of chemokine in metastatic destination of tumor cells. The present study was conducted to determine distribution of (Chemokine receptor 2) CCR2 V64I, Chemokine ligand 2 CCL2 I/D, and CCL2 2518 A>G gene polymorphisms in North Indian population and compare with different populations globally. Polymerase chain reaction (PCR)-based analysis was conducted in 200 normal healthy individuals of similar ethnicity. Allelic frequencies in wild type (GG) of CCR2 V64I G>A were 63 % G; CCL2 I/D 42 % II; CCL2 2518 A>G 40.5 % A. The minor variant allele frequency in our population was as follows: 19.5 % for CCR2 V64I, 35.5 % for CCL2 I/D, 35.3 % for CCL2 2518 A>G. We further compared frequency distribution for these genes with various published studies in different ethnicity. Our results suggested that frequency in chemokine genes exhibit distinctive pattern in India that could be attributed to ethnicity variation. This could assist in high-risk screening of human exposed to environmental carcinogens and cancer predisposition in different ethnic groups. Thus, they signify an impact of ethnicity and provide a basis for future epidemiological and clinical studies. 相似文献
46.
India’s educational policy on inclusive education for students with disabilities is in sync with general global developments. Especially in the last couple of years there have been significant legislative achievements towards this endeavour. However, the implementation of inclusive education remains elusive. Besides this, teachers’ preparedness for inclusion has received little attention. This survey study had two aims. Firstly, we aimed at finding or constructing a reliable instrument to measure three aspects: the attitudes, knowledge about disability and inclusive teaching methods of regular schoolteachers. Secondly, we aimed to describe the outcomes of the three aspects. For attitudes and teaching methods we found a reliable instrument, which was selected for the usage in this study. We constructed and assessed the reliability of a scale in measuring knowledge about four disabilities: attention deficit hyperactivity disorder, dyslexia, intellectual disability and autistic spectrum disorder in pilot and main studies. The results revealed that teachers hold neutral attitudes towards inclusive education. Their knowledge about disabilities, however, was low, but knowledge about inclusive teaching methods was acceptable, which was a significant finding. The practical implications for preparing teachers to work towards inclusion are also discussed. 相似文献
47.
In this paper a method of electrospinning conducting and nonconducting biphasic Janus nanofibers using microfluidic polydimethylsiloxane (PDMS)-based manifolds is described. Key benefits of using microfluidic devices for nanofiber synthesis include rapid prototyping, ease of fabrication, and the ability to spin multiple Janus fibers in parallel through arrays of individual microchannels. Biphasic Janus nanofibers of polyvinylpyrrolidone (PVP)+polypyrrole (PPy)∕PVP nanofibers with an average diameter of 250 nm were successfully fabricated using elastomeric microfluidic devices. Fiber characterization and confirmation of the Janus morphology was subsequently carried out using a combination of scanning electron microscopy, energy dispersion spectroscopy, and transmission electron microscopy. 相似文献
48.
49.
The current epidemic affecting Indians is coronary artery disease (CAD), and is currently one of the most common causes of mortality and morbidity in developed and developing countries. The higher rate of CAD in Indians, as compared to people of other ethnic origin, may indicate a possible genetic susceptibility. Hence, Lp(a), an independent genetic risk marker for atherosclerosis and cardiovascular disease assumes great importance. Lp(a), an atherogenic lipoprotein, contains a cholesterol rich LDL particle, one molecule of apolipoprotein B-100 and a unique protein, apolipoprotein (a) which distinguishes it from LDL. Apo(a) is highly polymorphic and an inverse relationship between Lp(a) concentration and apo(a) isoform size has been observed. This is genetically controlled suggesting a functional diversity among the apo(a) isoforms. The LPA gene codes for apo(a) whose genetic heterogeneity is due to variations in its number of kringles. The exact pathogenic mechanism of Lp(a) is still not completely elucidated, but the structural homology of Lp(a) with LDL and plasmin is possibly responsible for its acting as a link between atherosclerosis and thrombosis. Upper limits of normal Lp(a) levels have not been defined for the Indian population. A cut off limit of 20 mg/dL has been suggested while for the Caucasian population it is 30 mg/dL. Though a variety of assays are available for its measurement, standardization of the analytical method is highly complicated as a majority of the methods are affected by the heterogeneity in apo(a) size. No therapeutic drug selectively targets Lp(a) but recently, new modifiers of apo(a) synthesis are being considered. 相似文献
50.
Lipid peroxidation (MDA) was studied spectrophotometrically in relation to lipidemic status and atherogenic index in IHD and IHD risk subjects. It was found to be significantly elevated compared to control subjects (P<0.005) in both the groups, showing a linear correlation with cholesterolemic status. The values were found to run parallel to atherogenic index. In 10% cases with borderline atherogenic index the lipid peroxidation was found to be highly elevated. It is speculated that it may have a future role as a marker for IHD risk specially in premature group. 相似文献