全文获取类型
收费全文 | 570篇 |
免费 | 2篇 |
国内免费 | 1篇 |
专业分类
教育 | 255篇 |
科学研究 | 276篇 |
各国文化 | 3篇 |
体育 | 2篇 |
文化理论 | 3篇 |
信息传播 | 34篇 |
出版年
2023年 | 9篇 |
2022年 | 7篇 |
2021年 | 20篇 |
2020年 | 5篇 |
2019年 | 10篇 |
2018年 | 36篇 |
2017年 | 25篇 |
2016年 | 25篇 |
2015年 | 29篇 |
2014年 | 29篇 |
2013年 | 57篇 |
2012年 | 16篇 |
2011年 | 19篇 |
2010年 | 25篇 |
2009年 | 28篇 |
2008年 | 23篇 |
2007年 | 19篇 |
2006年 | 30篇 |
2005年 | 22篇 |
2004年 | 17篇 |
2003年 | 24篇 |
2002年 | 10篇 |
2001年 | 9篇 |
2000年 | 8篇 |
1999年 | 7篇 |
1998年 | 13篇 |
1997年 | 7篇 |
1996年 | 3篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 5篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有573条查询结果,搜索用时 15 毫秒
531.
Chandana Das V. Senthil Kumar Sayantani Basak Surabhi Gupta Sunesh Kumar 《Indian journal of clinical biochemistry : IJCB》2000,15(1):60-62
A female patient who had two primary cancers was investigated. Biochemical analysis of patient's serum for different parameters
indicated an alteration in the metabolic process. Prognostically, the patient has shown favourable clinical features. 相似文献
532.
Chethana Chetan Ashok Prabhu Vivian D'Souza Shrinivas B. Rao 《Indian journal of clinical biochemistry : IJCB》2000,15(1):17-21
Blood RBC's were used to study the role of polyamines, putrescine, spermidine and spermine individually as antioxidants against
the peroxidative action of H2O2 which leads to haemolysis of erythrocytes. Results indicated that putrescine did not act as antioxidant at all concentrations
used in our studies. However, spermidine and spermine suppressed peroxidative changes in RBC's due to the action of H2O2 and this suppression was greater with higher concentration of these individual polyamines used, separately. Further, all
the three polyamines decreased haemolysis of erythrocytes at all concentrations studied. The action of putrescine to suppress
haemolysis of RBC's without showing antioxidant property hypothetically suggests that these properties of respective polyamines
may have independent mechanism of action. 相似文献
533.
Sunil Kumar Gupta R. C. Gupta Kapil Gupta H. P. Trivedi 《Indian journal of clinical biochemistry : IJCB》2008,23(2):176-180
This study was conducted to find out the possible underlying mechanism of various manifestation of fluorosis, a disease caused
by excess ingestion of fluoride. For this the fluoride belt of Jaipur district was selected. The parameters selected were
serum Parathyroid hormone, the levels of which are directly affected by fluoride intake. The levels of serum seromucoid, serum
and leucocyte ascorbic acid, serum sialic acid (SSA) reflects ground substance metabolism. The study was conducted on two
hundred children, selected from four areas (50 from each area) consuming water containing 2.4, 4.6, 5.6 and 13.6 mg/l of fluoride.
Drinking water fluoride and serum fluoride were measured by Ion selective electrode method. Serum parathyroid by RIA and all
other parameters were measured spectrophotometrically. The results revealed an increase in levels of fluoride, parathyroid
hormone and seromucoid in serum with increasing water fluoride concentrations. Serum Calcium and serum ascorbic acid were
found in normal range, how ever leucocyte ascorbic acid were decreased. A high positive correlation among fluoride concentration
in drinking water and serum parathyroid hormone (r=0.967), and, serum parathyroid hormone and serum seromucoid concentration
(r=0.935) was also observed The results indicated that secondary hyperparathyroidism due to hypocalcemic stress caused by
excess fluoride ingestion disturbs normal metabolism of ground substance in calcified tissues of the body reflected as altered
levels of the components of ground substance in the serum. 相似文献
534.
Rajinder K. Dhamija Sarika Arora P. Gaba M. Jais A. Kaintura M. Kumar J. Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2008,23(2):136-143
Stroke is the third leading cause of death and foremost cause of disability. Based on studies in CAD patients, a focus has
been shifted on genetic and inflammatory markers as risk factors for stroke besides deranged lipid profile. The present study
was aimed to ascertain the role of Lipoprotein (a), C-Reactive protein (CRP) levels and lipids in patients of ischemic stroke.
The study was done in 82 subjects including 40 Computerized Tomography (CT) proven patients of ischemic stroke and 42 age
and sex matched controls. Complete biochemical parameters including lipid profile were carried out on autoanalyzer using standard
kits and reagents. Lipoprotein (a) [Lp(a)] was determined by immunoturbidimetric assay. Atherogenic indices (Total cholesterol/
HDL, LDL/HDL and Lipid Tetrad Index) were calculated using these lipid parameters. The CRP levels were measured semi-quantitatively
by latex agglutination test method. Out of 40 stroke patients, 38 had abnormalities in lipid profile (As per ATP III guidelines).
A significant difference was seen in serum cholesterol, LDL cholesterol and atherogenic indices between the patients and controls.
The difference in CRP levels in cases and control subjects was highly significant (4.78±0.72 mg/dl vs 0.76 ±0.70, p<0.001).
96.5% of patients with raised CRP had abnormal lipid levels also. CRP levels in stroke patients showed significant correlation
with total cholesterol and LDL (p<0.001), Lp (a) (p=0.002) and atherogenic indices (p<0.05). Raised CRP levels in stroke patients
were significantly associated with large territory infarcts, severe disability and poor functional outcome (p<0.05).Genetic
[Lp(a)], metabolic (deranged Lipid profile) and inflammatory factors (CRP) together are instrumental in causing cerebrovascular
arteriosclerosis leading to ischaemic stroke and can be used as important markers to identify patients at risk of severe stroke
and to institute aggressive preventive strategies. 相似文献
535.
Prashant Kumar Rai Dolly Jaiswal Devendra K. Rai Bechan Sharma Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2008,23(4):387-390
In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of
1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino
transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein
and body weight was increased. No toxic effect was observed during LD50. Our study suggests that further detailed toxicity
studies and mechanism of action of T. dioica would be useful for undertaking human trials. 相似文献
536.
537.
Ashwini Kumar H. S. Batra Mithu Banerjee S. Bandyopadhyay T. K. Saha Pratibha Misra Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2017,32(3):343-346
Thalassemia is a congenital hemolytic disease which is treated by repeated blood transfusion. Chronic iron overload is currently considered to be the primary cause of mortality in β-thalassemia, mainly due to the induction of left-sided cardiac failure. Iron overload results from a number of mechanisms associated with the disease itself. In addition to chronic iron overload thalassemic patients are more prone for procoagulant status which in turn lead to clinical thrombotic events. The hypercoagulable state in thalassemia is due to multiple elements, a combination of which is often the drive behind a clinical thromboembolic events. PAI-1 study was done in thalassemia major patients receiving multiple blood transfusion as a marker for procoagulant status. Total of 30 thalassemic patients on repeated blood transfusion was included in the study and total of 30 healthy age and sex matched controls were included in the study. It was also found that there was significant differences between cases and controls. The mean level of PAI 1 in controls was 3047 ± 414 pg/ml, the value in cases was 3683 ± 358 pg/ml. The level was significantly increased (p < 0.05) in the cases compared to controls. PAI-1 levels were also compared with the total number of blood transfusion which correlates well. 相似文献
538.
539.
R. Senthil Kumar T. N. Pattabiraman 《Indian journal of clinical biochemistry : IJCB》1996,11(2):152-157
A chymotrypsin-like enzyme was purified from rat plasma, involving ammonium sulfate fractionation and chromatographgy on CM-sephadex and red sepharose. The purified enzyme effectively hydrolysed the ester substrates for chymotrypsin (N-acetyl L-tyrosine ethyl ester and N-acetyl L-tryptophan ethyl ester). The Km values for the two substrates were 2.2×10?3M and 9.0×10?3M respectively. The hydrolytic activity of the enzyme was inhibited by phenylmethyl sulfonyl fluoride and tosylphenylalanine chloromethylketone, suggesting the presence of serine and histidine at the active centre. The enzyme exhibited anionic nature and possessed a high molecular weight (MW 71,000) as observed by gel exclusion chromatography on Sephadex G-200. The enzyme was stable upon exposure to pH 7.0–9.0, but was inactivated upon heat treatment at 60°C for 5 min. 相似文献
540.
Medically diagnosed alcoholics can be differentiated reliably from non-alcoholics using clinically laboratory tests. In the
present study, patients with liver diseases either due to alcohol or without alcohol compared with a group of normal healthy
persons. Heavy drinkers showed significantly lower body weight and percent body fat, and low BMI compared with other groups.
The percentage of hemoglobin and total number of RBC were found to be significantly decreased, whereas mean corpuscular volume
(MCV) significantly increased in alcoholic liver disease (ALD). Hyperbilirubinemia, hyperuricemia and hypoalbuminemia correlate
with alcohol intake. Albumin/globulin ratio significantly decreased in ALD. In acute liver injury AST/ALT ratio is ≤1.0, whereas
in alcoholic hepatitis it is always >1.0. Moderately elevated level of ALP and high GGT values are good discriminator of alcoholic
patients. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased level of reduced glutathione
and ascorbic acid, and increased level of thiobarbituric acid reactive substances. 相似文献