“P53 Codon 72 Single Base Substitution in Viral Hepatitis C and Hepatocarcinoma Incidences”

Viral infection with hepatitis C virus (HCV) has a high propensity in becoming chronic and it is the major cause of hepatocellular carcinoma (HCC) worldwide. This review was basically established to illustrate the putative role of the P53 gene Arg72Pro polymorphism on various cancer models and viral infections, focusing on HCV and HCC incidences. Authors studied the 72 G/C single base substitution of P53 gene at codon 72 using various polymorphic techniques. Intriguingly, authors investigated that the P53 codon 72 plays a crucial role as risk factor in several cancer models. Others found that there is no association between codon 72 genotypes and HCV disease severity or liver cancer. Moreover, the lack of a significant relationship between this polymorphism and risk of HCC shows that it does not predispose towards hepatocarcinogenesis and the frequent loss of the proline allele in HCV-associated carcinogenesis of the liver plays some critical role in hepatocarcinogenesis. Amazingly, there is a significant correlation between male homozygotes for P53 72Pro with HCV type 1b infection. However, there was no significant difference between the P53 polymorphism and HCV genotypes 2a and 2b. It was concluded that the P53 gene polymorphism at codon 72 has been investigated as potential risk factor in several cancer models and HCV infections.     

Predictors of psychological distress and positive resources among Palestinian adolescents: trauma, child, and mothering characteristics

OBJECTIVE: The aim was to examine how traumatic and stressful events, responses to violence, child characteristics, and mothering quality, as measured in middle childhood predict psychological distress and positive resources in adolescence. METHOD: The participants were 65 Palestinian adolescents (17+/-.85 years; 52% girls), who had been studied during the First Intifada (T1), during the Palestinian Authority rule (T2) and before the Second Al Aqsa Intifada (T3) in Gaza. Psychological distress was indicated by PTSD, and depressive symptoms and positive resources by resilient attitudes and satisfaction with quality of life, all measured at T3. The predictors that were measured at T1 were exposure to military violence, active coping with violence and children's intelligence, cognitive capacity, and neuroticism. Mothering quality and stressful life-events were measured at T2, the former reported by both the mother and the child, and the latter by the mother. RESULTS: Adolescents' PTSD symptoms were most likely if they had been exposed to high levels of traumatic and stressful experiences and had poor cognitive capacity and high neuroticism in middle childhood. Only high levels of childhood military violence and stressful life-events predicted high depressive symptoms and low satisfaction with quality of life in adolescence. CONCLUSIONS: Military violence in childhood forms risks for both increased psychological distress and decreased positive resources. However, child characteristics such as cognitive capacity and personality are important determinants of psychological vulnerability in military trauma.     

Urban transportation network analysis from a thermodynamic perspective

The paper explores the application of thermodynamic formalism to model and control transportation networks. Specifically, by considering the vehicles as the abstract energy supplied to the system, we show in certain circumstances that certain thermodynamic concepts such as temperature, thermal capacity and thermal equilibrium can have the corresponding notions in transportation context. In addition, despite the lack of a natural principle in transportation context that corresponds to the second law of thermodynamic as we will show, the most important thermodynamic notion, which is the entropy, can be also defined in order to measure the disorder of transportation systems. It is then shown that the state when all lanes have the same occupancy corresponds to the thermal equilibrium arising in isolated thermodynamic system. This equilibrium occupancy leads to a minimum entropy corresponding to a minimal disorder. Besides, by taking the transportation entropy as the storage function, a robust dissipativity based control strategy is presented to reduce the disorder and render the system better organized. Finally, an example is worked out to illustrate the results.     

Exploring the use of the ICT in supporting dyslexic students’ preferred learning styles : A preliminary evaluation

Dyslexia is one of the most common learning disabilities. It is described as a disorder manifested by difficulty in learning to read despite conventional instruction, adequate intelligence, and sociocultural opportunity. It affects relatively about 7–10 % of the population across most languages and cultures. In this study, we explore the potential benefits offered by the use of Information and Communication Technology (ICT) to support dyslexic students by considering their preferred learning styles. In the current paper we administered the VAK and Honey & Mumford questionnaires to 28 Arabic students with ages between 8 and 10 years old. 8 students from dyslexic group and 20 students from control group were selected to assess and compare their preferred learning style. The implemented system focuses on dyslexia in Arabic language, especially in Arabic countries such as Morocco. Based on the results of the analysis of learning styles differences, we introduced an adaptive mobile learning to support and promote learning for dyslexic students. The aim of the study is to consider the relationship between dyslexia and learning style and to suggest a different learning way. Preliminary results show that the ICT has a valuable role in providing opportunities for learners with dyslexia to participate more fully in education.     

Perspectives of University Students and Faculty on remote education experiences during COVID-19- a qualitative study

Education and Information Technologies - Owing to COVID-19 the Ministry of Education in the United Arab Emirates mandated educational institutions to shift to remote learning. In this study the...     

Game-based learning platform to enhance cybersecurity education

Education and Information Technologies - Computer security competitions have been playing a significant role in encouraging students to get into cybersecurity, as well as enhancing the...     

Egg-laying preference for ethanol involving learning has adaptive significance inDrosophila melanogaster

To study the influence of negative or positive experience of the ingestion of ethanol in femaleDrosophila with thefast form of the Adh gene on the acceptance of a medium containing this substance as site for egg laying, flies raised on a medium without alcohol were kept (1) on a regular medium, (2) on a medium supplemented with ethanol, (3) on a medium supplemented with 4-methylpyrazole (4-MP, an inhibitor of the enzyme ADH), and (4) on a medium containing both ethanol and this inhibitor. Whereas theDrosophila exhibited no spontaneous egg-laying preference for ethanol, a preference was induced by the ingestion of this substance, which also led to an increase in the number of eggs laid. By contrast, ingestion of ethanol, associated with the inhibitor, reduced the number of eggs laid and led to an avoidance of ethanol-containing media. Flies treated with ethanol and 4-MP exhibited signs of sickness (reduction in locomotor activity and loss of balance). The egg-laying preference for the ethanol results from learning linked to the metabolic utilization of this alcohol. The adaptative significance of this learning is discussed.     

The impetus for organisational change: An exploration

Abstract

This paper examines the factors that cause universities to undertake academic change, specifically, changes to achieve more effective teaching and learning. Based on an analysis of 30 reform‐oriented US colleges and universities, it suggests that universities respond to diverse environmental pressures, not solely to external mandates. There is evidence, too, that internal forces within universities can be an impetus for change.     

Individual participant data meta-analysis of the impact of educational interventions on pupils eligible for Free School Meals

Meta-analysis is the synthesis of findings from research projects, which enables an estimate of the average or pooled effect across various studies. This study presents findings from the intention to treat analysis for a series of educational evaluations in England using a two-stage meta-analysis with standardised outcome data and individual participant data meta-analyses. The research estimates the overall impact of educational trials on pupils eligible for Free School Meals (FSM) and the attainment gap in literacy and mathematics performance between FSM and non-FSM pupils based on analysis of 88 trials and data from over half a million pupils. For the meta-analyses, frequentist and Bayesian multilevel models were used to estimate the individual and pooled effect size across categories of explanatory variables such as age groups (key stages in England) and aspects of the type of interventions (one-to-one, small group, whole class). Results indicated that the overall impact of interventions on the literacy outcomes of FSM pupils was positive, with a pooled effect size of 0.06 (0.03, 0.08). However, for mathematics, no overall effect on FSM pupils was observed. Analysis of the attainment gap indicated that literacy outcomes for FSM pupils were improved by interventions marginally more than for non-FSM pupils (pooled attainment gap 0.01 (−0.01, 0.04)). The risk of bias assessment showed that estimates were consistent across different methodological approaches. Overall, evidence from this study can be used to identify, test and scale educational interventions in schools to improve educational outcomes for disadvantaged pupils.     

Institutional repository software platforms at undergraduate libraries in the United States

For primarily undergraduate institutions, institutional repositories can become effective tools for communicating and showcasing faculty and student research, facilitating open access initiatives, or supporting new scholarly communication practices. Choosing the right software platform is crucial to the success of a repository initiative. The literature suggests that there are only two or three software platforms heavily used in undergraduate libraries. This article aims to give a landscape of the repository platforms used in sixty-seven undergraduate libraries in the United States in late 2013; it also includes the results of a short survey about current institutional repository software platforms and users/administrators’ satisfaction.