Performance evaluation of the high sensitive troponin I assay on the Atellica IM analyser

IntroductionThe Fourth Universal Definition of Myocardial Infarction Global Taskforce recommends the use of high sensitive troponin (hs-Tn) assays in the diagnosis of acute myocardial infarction. We evaluated the analytical performance of the Atellica IM High-sensitivity Troponin I Assay (hs-TnI) (Siemens Healthcare Diagnostics Inc., Tarrytown, USA) and compared its performance to other hs-TnI assays (Siemens Advia Centaur, Dimension Vista, Dimension EXL, and Abbott Architect (Wiesbaden, Germany)) at one or more sites across Europe.Materials and methodsPrecision, detection limit, linearity, method comparison, and interference studies were performed according to Clinical and Laboratory Standards Institute protocols. Values in 40 healthy individuals were compared to the manufacturer’s cut-offs. Sample turnaround time (TAT) was examined.ResultsImprecision repeatability CVs were 1.1–4.7% and within-lab imprecision were 1.8–7.6% (10.0–25,000 ng/L). The limit of blank (LoB), detection (LoD), and quantitation (LoQ) aligned with the manufacturer’s values of 0.5 ng/L, 1.6 ng/L, and 2.5 ng/L, respectively. Passing-Bablok regression demonstrated good correlations between Atellica IM analyser with other systems; some minor deviations were observed. All results in healthy volunteers fell below the 99th percentile URL, and greater than 50% of each sex demonstrated values above the LoD. No interference was observed for biotin (≤ 1500 µg/L), but a slight bias at 5.0 g/L haemoglobin and 50 ng/L Tn was observed. TAT from was fast (mean time = 10.9 minutes) and reproducible (6%CV).ConclusionsReal-world analytical and TAT performance of the hs-TnI assay on the Atellica IM analyser make this assay fit for routine use in clinical laboratories.     

Relationship between serum phenytoin and creatinine levels in grand mal epilepsy

Serum phenytoin levels were measured in grand mal epilepsy patients receiving diphenyl hydantoin. The drug levels were correlated with various biochemical parametres. A linear relationship between the levels of diphenyl hydantoin and creatinine was observed. This positive correlation coefficient was found to be statistically signifficant. This correlation may be related to a positive Jaffe’s reaction seen with the chromogen diphenyl hydantoin.     

Changes in Children’s Agency Beliefs and Control Expectancy in Classes With and Without a Special Emphasis in Finland from Grade Four to Grade Six

This study examined changes in pupils’ agency beliefs and control expectancy from grade four to grade six, and whether they were associated with studying in a class with a special emphasis on a subject as compared to studying in a class without emphasis. After controlling for the effects of mother’s education, prior school achievement, and gender, we found that the average pattern of change varied for different action-control beliefs, and that class membership did not moderate these changes. Mother’s education, pupils’ prior school achievement, and gender all predicted class membership, but their effects on action-control beliefs varied depending on the type of belief. Implications for educational policy will be discussed.     

Professional development,changes in teacher practice and improvements in Indigenous students’ educational performance: A case study from New Zealand

This paper considers the relationship between a professional development programme designed to bring about changes in teacher practice through iterative cycles of implementation and evaluation and associated changes in Indigenous students’ educational performance. The paper does this by documenting the outcomes of the implementation of the Te Kotahitanga research and development project between 2007 and 2009 in schools in the third and fourth phases of the project. Evidence shows that the professional development programme of Te Kotahitanga has been implemented consistently in Phase 3 schools since 2004 and in Phase 4 schools since 2007. Changes in teacher practice and associated improvements in Māori student outcomes were seen in Phase 3 schools between 2004 and 2006. The first question is, therefore, have these changes been maintained during the period 2007–9, that is, during the fourth to seventh years of the project’s implementation in these schools. If so, then what implications does this maintenance of practice have for sustainability? The second question is, have the changes that were seen in the Phase 3 schools in the first three years of the project’s implementation, 2004–2006, been replicated in the Phase 4 schools in their first three years of the project. If so, what implications does this have for determining the strength of the association between improved student performance and the implementation of the professional development programme. In other words does a repeated measure over two different groups of schools at different times indicate that changes in Māori student outcomes are strongly associated with changes in teacher practice, even if we cannot demonstrate a direct cause–effect relationship.     

Management by Results and Higher Education Evaluation as Fashions and Success Stories: The Case of Finland1

Fashion is easily understood as something to do with style and consumption. However, the concept of fashion can also be applied when organisations and the change in them is analysed and explained. Universities and their departments adopt different kinds of policy fashions. This article approaches management by results and evaluation in the Finnish context as fashions and success stories which universities and their departments have either accepted or rejected. Fashions and reactions to them have created new practices and cultures, and simultaneously either displaced the old practices or taken their place with them. Fashions are further translated into local action at universities and their departments.     

¿Se puede prevenir la inadaptación escolar?

RESUMEN

Para tratar de disminuir el número de inadaptaciones escolares en la enseñanza elemental, en los últimos años se ha generalizado la perspectiva de la prevención. Se realizó un estudio sociológico con 1.238 niños de párvulos que confirmó las estrechas relaciones existentes entre el fracaso escolar y el origen social. Se concluye, pues, que el hándicap socio-cultural engloba dos ideas: la estrecha relación entre origen socioeconómico y desarrollo psicológico; y las desigualdades culturales de las familias según su pertenencia social. Para comprender correctamente el fenómeno del fracaso escolar, es preciso analizar las relaciones entre la institución escolar y los diferentes ambientes, y estudiar el papel de la primera en la génesis de las dificultades del niño.     

Developing an effective education reform model for indigenous and other minoritized students

Educational disparities between indigenous Maori students and those of the majority continue to be a major issue in New Zealand. Te Kotahitanga, an iterative research and development programme, which commenced in 2001, supports teachers to implement a relationship-based pedagogy in their classrooms in order to improve Maori students' achievement in mainstream secondary schools. This article addresses the question of how gains in Maori students' achievement can be sustained and expanded. Schools, from an earlier phase of the project, in their 6th and 7th year of the programme were examined, using a theory-based model designed to evaluate and promote dimensions necessary for effective institutional support of the teaching innovation. This article demonstrates that schools that have been the most effective implementers of the intervention have seen the greatest gains made by Maori students in the 1st year of national assessments. This article then discusses effective leadership for addressing problems schools encountered while implementing the pedagogic reform.     

Exploring the minority–majority gap in sport participation: different patterns for boys and girls?

Abstract

This paper examines the participation of minority and majority youth in organized sport based on the Young in Oslo 2015 survey (response rate: 72%, N = 9.774). Four possible explanations of the minority–majority gap are introduced: (i) culture, (ii) religion, (iii) discrimination/racism and (iv) class and socio-economic resources. Class and religion are further examined in the paper. Initially, among the boys, there are no differences between the minority and majority groups. When taking socio-economic resources into account, the minority boys have a slightly higher participation rate than the majority boys. Among the girls, the likelihood of participating in sport clubs is considerably lower for those with a minority background than for those with a majority background. The analyses show that socio-economic resources have an effect on both girls and boys and that religious denomination also explains, to some extent, the minority–majority gap that exists among girls.