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171.
Bandana Kumari Krishnan Hajela Asgar Ali Abhay Kumar Sharma Rajesh Kumar Yadav Alok Ranjan Rathish Nair Shreekant Bharti Satish Dipankar Prabhat Kumar Singh Sadhana Sharma 《Indian journal of clinical biochemistry : IJCB》2023,38(1):102
IntroductionDetecting low viral load has been a challenge in this pandemic, which has led to its escalated transmission. Complement activation has been implicated in pathogenesis of Covid-19 infection. Thus, evaluation of complement activation in suspected Covid-19 infection may help to detect infection and limit false negative cases thus limiting transmission of infection. We speculate that measuring C4b, produced from an activated complement system due to the presence of Covid-19 may help in its detection, even when the viral titers are low.MethodsPlasma C4b levels of symptomatic RT-PCR positive patients (cases, n = 40); symptomatic RT-PCR negative patients (n = 35) and asymptomatic RT-PCR negative controls (n = 40) were evaluated. Plasma C5b-9, IL-6, D-dimer and C1-Inhibitor (C1-INH) were also measured in cases and controls. ELISA kits were used for all measurements. Statistical analyses were carried out using Stata, version 12 (Stata Corp., Texas, USA).ResultsC4b levels were found to be significantly increased in RT-PCR positive patients as compared to asymptomatic RT-PCR negative controls. RT-PCR negative but symptomatic patients still showed increased C4b levels. The significantly higher levels of C4b in cases with a cut-off value of ≥ 116 ng/ml with optimum sensitivity and specificity of 80% and 52% respectively is indicative of its possible use as an adjunct marker. Increased levels of D-dimer, IL6, along with decreased levels of C1-INH were found in cases compared to controls. Whereas, C5b-9 levels were not significantly raised in cases.ConclusionsThe results of our study suggests that plasma C4b may help to detect infection in false negative cases of RT-PCR that escape detection owing to low viral load. However, to confirm it a large-scale study is needed.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12291-022-01033-z. 相似文献
172.
Das M Ghose M Borah NC Choudhury N 《Indian journal of clinical biochemistry : IJCB》2010,25(3):295-301
Till date no community based data on plasma homocysteine is available in North Eastern Region. Hence, the present study was
conducted to analyze and correlate the plasma homocysteine level with some life style factors like diet, alcohol intake, smoking
habit and body weight, in a cross-section of population. 12 h fasting samples of 970 apparently healthy, Assamese population
of both genders in the age group of 35–86 years, mostly from the urban area of Assam were tested for plasma total homocysteine
level over a period of 3 years. Out of 970 volunteers, hyperhomocysteinemia was detected in 533 (55%) individuals with a mean
value of 18.41 μmol/l. Of that hyperhomocysteinemia, 89.1% were in the range of moderately high and rest 10.9% were intermediate
high. Another finding was that males had a tendency towards greater value (mean = 20.36 μmol/l) than females (mean = 16.37 μmol/l).
It was observed that the relationship of homocysteine levels to gender and some of the life style factors were also significant. 相似文献
173.
Santosh C. Das Uche P. Isichei Aminu Z. Mohammed Abraham A. Otokwula Abiodun Emokpae 《Indian journal of clinical biochemistry : IJCB》2005,20(2):35-42
The effect of iodine deficiency (ID) on thyroid function in African women during pregnancy and postnatal period was examined,
for which very limited information is available. Serum T4, T3, TSH, TBG, thyroxine binding capacity (TBK), free thyroxine index (FT4I=T4/TBK) and T4/TBG were determined by ELISA technique in 32 pregnant women (resident of Plateau state, Nigeria- an ID zone) through pregnancy
upto term delivery, and in 5 women up to 6 weeks post delivery. Urinary iodide level was measured at delivery to determine
the degree of iodine deficiency. Results were matched with a non pregnant control comprising 44 subjects. 5555 birth weights
(BW) of term babies in the region were analysed to determine the prevalence of ‘small for dates’ (SFD) babies in the population.
Results show that the level of serum FT4I was elevated very significantly at late gestation (P<.001) but the women were not hyperthyroid, suggesting a marked disturbance
in binding of T4 with TBG during pregnancy. Five women with SFD babies were found in ‘compensated hypothyroid state’ and showed a significant
depression (p<.01) in serum T4/TBG, T4, FT4I and T3 levels to a low normal range, with a concurrent significant rise (p.<.001) in TSH level (above normal range) throughout pregnancy.
Incidence of SFD babies was higher (p.<.001) in ID zone (Bassa 15.2%) compared to control zone (Jos 9.8%). It is concluded
that a state of maternal ‘subclinical (compensated) hypothyroidism’ during pregnancy possibly plays an important role in the
aetiopathogenesis of SFD babies in Africans. A normal reference range for thyroid parameters at various stages of pregnancy
in healthy African women is established for the first time. 相似文献
174.
175.
Kapil D. Lahiri Himadri Datta Harendra N. Das 《Indian journal of clinical biochemistry : IJCB》2014,29(1):74-78
Hyperhomocysteinemia has been shown to be an independent risk factor for cardiovascular disease as well as retinal vascular occlusion. Because of the epidemiological, dietary, genetic and environmental diversity among the different countries, each country should establish the reference interval of homocysteine of their own population for recommending appropriate medical decision limits. Hence a total of 1,288 apparently healthy subjects including 636 male and 652 female were enrolled in the present study to determine the reference intervals of homocysteine in an Indian population. Results of the study were presented as mean, standard deviation, median and 2.5th and 97.5th percentile with the 0.90 confidence interval of each percentile values of homocysteine along with decade-wise changes. 相似文献
176.
177.
Medically diagnosed alcoholics can be differentiated reliably from non-alcoholics using clinically laboratory tests. In the
present study, patients with liver diseases either due to alcohol or without alcohol compared with a group of normal healthy
persons. Heavy drinkers showed significantly lower body weight and percent body fat, and low BMI compared with other groups.
The percentage of hemoglobin and total number of RBC were found to be significantly decreased, whereas mean corpuscular volume
(MCV) significantly increased in alcoholic liver disease (ALD). Hyperbilirubinemia, hyperuricemia and hypoalbuminemia correlate
with alcohol intake. Albumin/globulin ratio significantly decreased in ALD. In acute liver injury AST/ALT ratio is ≤1.0, whereas
in alcoholic hepatitis it is always >1.0. Moderately elevated level of ALP and high GGT values are good discriminator of alcoholic
patients. Alcohol-induced liver injury is linked to oxidative stress as observed by decreased level of reduced glutathione
and ascorbic acid, and increased level of thiobarbituric acid reactive substances. 相似文献
178.
The purpose of this study was to compare the contribution of two different versions of working memory to word reading and reading comprehension in relation to phonological awareness and rapid naming speed. Fifty children were administered two measures of working memory, namely an adaptation of the Daneman and Carpenter sentence span task and Sentence Question, tests of phonological awareness, rapid naming speed, word reading and reading comprehension. The results indicated that Sentence Question accounted for unique variance over and beyond the effects of Daneman and Carpenter's sentence span task, whereas the latter did not when the effects of Sentence Question were partialled out. In addition, both phonological awareness and rapid naming were accounting for unique variance beyond the effects of working memory in predicting reading. The role of working memory on reading is discussed, and future directions for research are suggested. 相似文献