Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma

Objective: Airway inflammation and airway hyper-responsiveness (AHR) are principle pathological manifestations of asthma. Cluster of differentiation 69 (CD69) is a well-known co-stimulatory factor associated with the activation, proliferation as well as apoptosis of immune cells. This study aims to examine the effect of anti-CD69 monoclonal antibody (mAb) on the pathophysiology of a mouse model of asthma. Methods: A murine model of ovalbumin (OVA)-induced allergic airway inflammation was used in this study. Briefly, mice were injected with 20 μg chicken OVA intraperitoneally on Days 0 and 14, followed by aerosol provocation with 1% (0.01 g/ml) OVA on Days 24, 25, and 26. Anti-CD69 mAb or isotype IgG was injected intraperitoneally after OVA challenge; dexamethasone (DXM) was administrated either before or after OVA challenge. AHR, mucus production, and eosinophil infiltration in the peribronchial area were examined. The levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-5 (IL-5) in bronchoalveolar lavage fluid (BALF) were also assayed as indices of airway inflammation on Day 28 following OVA injection. Results: Pretreatment with DXM together with anti-CD69 mAb treatment after OVA provocation completely inhibited AHR, eosinophil infiltration and mucus overproduction, and significantly reduced BALF IL-5. However, treatment with DXM alone after OVA challenge only partially inhibited AHR, eosinophil infiltration and mucus overproduction, and did not diminish BALF IL-5. Treatment with either DXM or anti-CD69 mAb did not alter the concentration of BALF GM-CSF. Conclusions: Anti-CD69 mAb treatment inhibits established airway inflammation as effectively as DXM pretreatment. This study provides a potential alternative therapeutic opportunity for the clinical management of asthma and its exacerbation.     

EDA在数字电子技术课程教学中的应用

介绍了应用EDA在“数字电子技术”的教学,说明了EDA具有辅助课堂教学和进行实验仿真的功能。结合实际应用总结了使用计算机辅助教学与传统课堂教学方式相比的特点,表明用EDA辅助教学改善了教学手段,丰富了教学内容,教学效果良好,对于教学水平的提高十分有益。     

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大力发展职业教育为推进沿江开发战略提供人才支撑

加快沿江开发,掀起新一轮开发开放的热潮,是江苏省委、省政府作出的重大决策,实施这一战略,可以进一步提升苏南发展水平,促进苏中快速崛起,激发苏北后发优势.     

论面向校企合作的高职院校组织体系的构建

工学结合、校企合作已经成为职业教育的重要办学思想,这一理念对高职院校的组织管理提出了挑战。工学结合、校企合作的真正落实需要构建完善的组织体系和运行机制。     

论性质形容词ABAB式重叠的词性

本文将动词ABAB式重叠与性质形容词ABAB 式重叠作对比,通过比较两者在功能、语法意义等多方面的特征来了解性质形容词ABAB式重叠的词性的变化。笔者认为性质形容词通过ABAB式重叠抛弃了形容词的词性特征而转性为动词,在使用中承担动词角色。     

浅谈如何培养农村中学后进生作文兴趣

我县位于大别山连片国家级贫困地区,经济发展水平比较低,文化教育事业也比较落后,农村基础教育更是薄弱环节,语文教育承担着更多的责任。如何让学生写好作文是每一个语文教师都在思索的问题,尤其是后进生的作文更是教学的难点,本文将从几个方面来探讨对策,以期达到提高后进生写作兴趣的目的。     

青南高原雪灾模拟评估与服务对策

对青南牧区逐旬最大积雪资料作了整理分析,提出了冬、春季雪灾的标准,并建立了雪灾等级序列年表,用相关普查初选雪灾等级的预报因子,利用精选因子,按最优子集回归原理,建立了雪灾的预报模拟评估方程,按预报模拟值的等级,提出了相应的服务对策。     

上市公司高级管理层对财务报告质量选择的博弈分析

本文在研究上市公司高级管理层(经营者)与股权投资者(所有者)对财务报告质量选择的博弈中,运用了不完全信息动态博弈中的信号传递博弈模型,该模型具体构造一个在给定上市公司质量高低类型的情况下,不同类型公司的经营者对财务报告质量选择的博弈过程,从而得出博弈结果达到分离均衡状态的条件,找出提高财务报告效用的途径,使得不同类型的经营者以1的概率选择不同的财务报告。