显微网络互动多媒体系统在遗传学实验教学中的应用效果

在遗传学实验教学中运用显微网络互动多媒体系统,弥补了单纯使用显微镜的不足;教师的演示、学生的反馈更及时,教师的指导更具有针对性,并加强了信息沟通和互动;强大的图片采集、保存与处理功能,有利于激发学生的实验兴趣,有利于加深对理论知识的理解;多画面的监控转播功能,可控制教学进度,提高实验课程效率和教学效果。     

论中外合作办学的可持续发展

当前,中外合作办学面临新的机遇与挑战。要实现中外合作办学可持续发展,必须遵循中外合作办学的基本规律,坚持引进优质教育资源的原则,坚持公益性原则,完善评估机制,加强质量监控与管理,坚持规范办学,严格依法管理。     

高职电子类专业“CDIO实践教学模式”探索

分析了传统高职电子类专业实践教学存在的主要问题,建立并实施了CDIO实践教学模式。结果表明：＂CDIO实践教学模式＂能够以接近电子工程实际所涉及的综合设计项目为主要载体,结合电子类实践环节的教学,使学生在CDIO的全过程中不断地在电子工程基础知识、个人能力、团队能力和工程系统能力4个方面得到全面的训练和提高。     

Development of a space cold atom clock

Atomic clocks with cold atoms play important roles in the field of fundamental physics as well as primary frequency standards. Operating such cold atom clocks in space paves the way for further exploration in fundamental physics, for example dark matter and general relativity. We developed a space cold atom clock (SCAC), which was launched into orbit with the Space Lab TG-2 in 2016. Before it deorbited with TG-2 in 2019, the SCAC had been working continuously for almost 3 years. During the period in orbit, many scientific experiments and engineering tests were performed. In this article, we summarize the principle, development and in-orbit results. These works provide the basis for construction of a space-borne time-frequency system in deep space.     

Convergent genomic signatures of high-altitude adaptation among domestic mammals

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.     

Superconductivity in chromium nitrides Pr3Cr10-xN11 with strong electron correlations

Exploration of superconductivity in Cr-based compounds has attracted considerable interest because only a few Cr-based superconductors (CrAs, A₂Cr₃As₃ and ACr₃As₃ (A = K, Rb, Cs, Na)) have been discovered so far and they show an unconventional pairing mechanism. We report the discovery of bulk superconductivity at 5.25 K in chromium nitride in Pr₃Cr_10-xN₁₁ with a cubic lattice structure. A relatively large upper critical field of H_c2(0) ∼ 12.6 T is determined, which is larger than the estimated Pauli-paramagnetic pair-breaking magnetic field. The material has a large electronic specific-heat coefficient of 170 mJ K⁻² mol⁻¹—about 10 times larger than that estimated by the electronic structure calculation, which suggests that correlations between 3d electrons are very strong in Pr₃Cr_10-xN₁₁, and thus quantum fluctuations might be involved. Electronic structure calculations show that the density of states at the Fermi energy are contributed predominantly by Cr 3d electrons, implying that the superconductivity results mainly from the condensation of Cr 3d electrons. Pr₃Cr_10-xN₁₁ represents a rare example of possible unconventional superconductivity emerging in a 3D system with strong electron correlations. Nevertheless, clarification of the specific pairing symmetry needs more investigation.     

Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair

Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic (IHI) nanoscaffold that facilitates fast assembly, enhances survival and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix (ECM) proteins assemble stem cells through synergistic 3D cell–cell and cell–matrix interactions, creating a favorable physical microenvironment for stem-cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3D stem-cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem-cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3D stem-cell assembly method, we provide a promising approach to better overcoming the inhibitory microenvironment associated with cartilage injuries and to advance current stem-cell-based tissue engineering.     

区域一体化对城市创新能力驱动研究——基于长三角的实证分析

长三角更高质量一体化发展标志着各种资源要素在长三角区域内的配置效率将进一步提升,有利于形成更强的区域创新能力。本文基于2005—2017年长三角城市统计数据,考察了区域一体化对城市创新能力的驱动作用,并对其中的影响机制和异质性进行了深入分析。结果显示：(1)区域一体化对长三角城市创新能力具有显著的促进作用。(2)机制分析发现,一体化伴随的产业集聚并未形成创新能力提升机制,但一体化推动的区域内部产业转移机制有效提升了城市创新能力。(3)异质性分析表明,长三角区域一体化对非核心城市、欠发达城市、低财政分权城市具有更为显著的城市创新能力驱动作用。     

Water molecules bonded to the carboxylate groups at the inorganic–organic interface of an inorganic nanocrystal coated with alkanoate ligands

High-quality colloidal nanocrystals are commonly synthesized in hydrocarbon solvents with alkanoates as the most common organic ligand. Water molecules with an approximately equal number of surface alkanoate ligands are identified at the inorganic–organic interface for all types of colloidal nanocrystals studied, and investigated quantitatively using CdSe nanocrystals as the model system. Carboxylate ligands are coordinated to the surface metal ions and the first monolayer of water molecules is found to bond to the carboxylate groups of alkanoate ligands through hydrogen bonds. Additional monolayer(s) of water molecules can further be adsorbed through hydrogen bonds to the first monolayer of water molecules. The nearly ideal environment for hydrogen bonding at the inorganic–organic interface of alkanoate-coated nanocrystals helps to rapidly and stably enrich the interface-bonded water molecules, most of which are difficult to remove through vacuum treatment, thermal annealing and chemical drying. The water-enriched structure of the inorganic–organic interface of high-quality colloidal nanocrystals must be taken into account in order to understand the synthesis, processing and properties of these novel materials.     

女性主义伦理学视野下道德教育的性别和谐

女性主义伦理学研究表明,道德是有“性别”之分的,男女两性在道德价值重心、思维方式和发展方式上均有差异。但道德教育理论和实践中客观存在的性别歧视,导致道德教育的性别失衡和性别冲突,从而限制了道德教育的发展。实现道德教育的性别和谐应该消除性别歧视,重新定义道德和有道德的人,使道德教育的核心概念包容女性气质。在此基础上,重建道德教育大厦,使其矗立于理性和情感的根基之上。