Yer Doin’ it Wrong: How NOT to Interact with Vendors,Publishers, or Librarians

Three librarians who have extensive experience working in libraries or for publishers, vendors, or consortia presented an informal discussion on librarian–vendor relationships. The audience was encouraged to participate. Problems were articulated; speakers and audience members contributed suggestions for better approaches or behaviors when handling difficult situations.     

Hydrodynamic self-focusing in a parallel microfluidic device through cross-filtration

The flow focusing is a fundamental prior step in order to sort, analyze, and detect particles or cells. The standard hydrodynamic approach requires two fluids to be injected into the microfluidic device: one containing the sample and the other one, called the sheath fluid, allows squeezing the sample fluid into a narrow stream. The major drawback of this approach is the high complexity of the layout for microfluidic devices when parallel streams are required. In this work, we present a novel parallelized microfluidic device that enables hydrodynamic focusing in each microchannel using a single feed flow. At each of the parallel channels, a cross-filter region is present that allows removing fluid from the sample fluid. This fluid is used to create local sheath fluids that hydrodynamically pinch the sample fluid. The great advantage of the proposed device is that, since only one inlet is needed, multiple parallel micro-channels can be easily introduced into the design. In the paper, the design method is described and the numerical simulations performed to define the optimal design are summarized. Moreover, the operational functionality of devices tested by using both polystyrene beads and Acute Lymphoid Leukemia cells are shown.     

‘Muscles for Motherhood’: A Genealogical Analysis of Medicalized Ways of Knowing Female Footballers in New Zealand, 1921 and 1973–1975

ABSTRACT

Michel Foucault argued that females gradually became integrated into the sphere of medical practices through a process which he termed as a ‘hysterization of women’s bodies’ (Foucault, The History of Sexuality, Volume One: An Introduction, New York: Pantheon Books, 1978, 104). In this article, we draw on Foucault to examine how women’s bodies, exercise and motherhood impacted on the historical development of female football in New Zealand within two time periods (1921 and 1973–1975). Employing his genealogical framework, we analyze newspaper reports, historical documents and conducted in-depth interviews to demonstrate how medical/scientific discourses both constrained and enabled the participation of women in football. We conclude that while medical knowledge was used to publicly disqualify the legitimacy of the female footballer in 1921, and hence her abrupt disappearance from the sporting realm, the absence of such medical knowledge in the early 1970s, combined with societal changes associated with second wave feminism, paved the way for the eventual ‘normalization’ of female football in New Zealand.     

Core-shell hydrogel beads with extracellular matrix for tumor spheroid formation

Creating multicellular tumor spheroids is critical for characterizing anticancer treatments since they may provide a better model of the tumor than conventional monolayer culture. Moreover, tumor cell interaction with the extracellular matrix can determine cell organization and behavior. In this work, a microfluidic system was used to form cell-laden core-shell beads which incorporate elements of the extracellular matrix and support the formation of multicellular spheroids. The bead core (comprising a mixture of alginate, collagen, and reconstituted basement membrane, with gelation by temperature control) and shell (comprising alginate hydrogel, with gelation by ionic crosslinking) were simultaneously formed through flow focusing using a cooled flow path into the microfluidic chip. During droplet gelation, the alginate acts as a fast-gelling shell which aids in preventing droplet coalescence and in maintaining spherical droplet geometry during the slower gelation of the collagen and reconstituted basement membrane components as the beads warm up. After droplet gelation, the encapsulated MCF-7 cells proliferated to form uniform spheroids when the beads contained all three components: alginate, collagen, and reconstituted basement membrane. The dose-dependent response of the MCF-7 cell tumor spheroids to two anticancer drugs, docetaxel and tamoxifen, was compared to conventional monolayer culture.     

心的中心地位:道家之间的论战

心与身体其他感觉器官的关系问题,备受先秦两汉所有重要思想流派的争议。众所周知,传统儒家认为心是主"情"的器官,并具有分析其他感官之间差异的能力1。对于孟子来说,"四端"学说就是关于"心"的内容,最为显著的是恻隐之心,它能促进人们德性的成长2。对于儒家来说,与其他自然的感觉器官相比,"心"是较为高级的。因为它不仅具有思考的能力,而且能评估人们所遇之事;而其他感知器官,仅仅是在于接触其他事物3。"心"比其     

Flipping the classroom to teach systematic reviews: the development of a continuing education course for librarians

Objective:The researchers used the flipped classroom model to develop and conduct a systematic review course for librarians.Setting:The research took place at an academic health sciences library.Method:A team of informationists developed and conducted a pilot course. Assessment informed changes to both course components; a second course addressed gaps in the pilot.Conclusion:The flipped classroom model can be successful in developing and implementing a course that is well rated by students.     

#MeToo,sexual harassment: an article,a forum,and a dream for the future

#MeToo has breathed new life into the women’s movement and especially into understanding and rectifying sexual harassment, abuse and assault. It has galvanized activists around the globe. And it has placed thousands of stories of the harassed in full view of the public. Sexual harassment, abuse and assault may occur within the organizational context or beyond; but sexual harassment, in particular has been legally labeled an organizational phenomenon. With this in mind, Robin Clair frames the early part of this article around the most recent organizational communication theories (see the appendix for an overview of these theories). Following the essay is a forum, in which invited scholars address questions related to the #MeToo movement.