Chemical air filtration in archives and libraries reconsidered

The implementation of chemical filtration in air-conditioning systems in archive and library repositories has become standard practice for heritage institutions in many countries. This practice is codified in official standards with general reference to a substantial body of scientific publications on the effects of air pollutants on paper materials. In this paper we report the application of a well-established decision analysis approach elaborating an integral cost-benefit perspective to provide decision support to four European national heritage institutions confronted with dilemmas in connection to chemical air filtration. Available scientific evidence for air pollution induced damage of paper material is reviewed and weighed against financial and environmental costs of air pollution control. Exposure of paper to both indoor and outdoor generated air pollutants at typical concentration levels observed within storage areas is expected to cause minimal to no additional yellowing and embrittlement, while the costs of chemical air filtration are significant. From a cost-benefit perspective the use of chemical air filtration in typical library and archive repositories is therefore discouraged.     

Inhibition of exploratory behavior in the rat by handling

The effect of tail-handling on exploratory behavior of the rat, measured as step-through latency in a well-lighted, two-box apparatus, was investigated. Male adult Wistar rats, aged 60 days, were employed in all three experiments. Experiment 1, in which the subjects were handled at different times after entering the goal chamber (0, 10, 30, 60, 300, and 600 sec), showed that immediate handling, relative to detention in the goal chamber (delay of handling) had an inhibitory effect on exploration. Experiment 2 showed that groups handled immediately after entering the goal chamber but then detained there for different durations all showed the same progressive inhibition of exploration. Experiment 3 showed that the inhibition of exploration (very long step-through latencies) due to tail-handling immediately after entering the goal chamber could be significantly decreased by further trials in which handling was delayed for a sufficient duration (30 sec or more). Handling is discussed as a stimulus that is aversive enough to elicit conditioned passive-avoidance responses (inhibition of exploratory behavior), although it is subject to rapid extinction.     

pH controlled staining of CD4+ and CD19+ cells within functionalized microfluidic channel

Herein proposed is a simple system to realize hands-free labeling and simultaneous detection of two human cell lines within a microfluidic device. This system was realized by novel covalent immobilization of pH-responsive poly(methacrylic acid) microgels onto the inner glass surface of an assembled polydimethylsiloxane/glass microfluidic channel. Afterwards, selected thiophene labeled monoclonal antibodies, specific for recognition of CD4 antigens on T helper/inducer cells and CD19 antigens on B lymphocytes cell lines, were encapsulated in their active state by the immobilized microgels. When the lymphocytes suspension, containing the two target subpopulations, was flowed through the microchannel, the physiological pH of the cellular suspension induced the release of the labeled antibodies from the microgels and thus the selective cellular staining. The selective pH-triggered staining of the CD4- and CD19-positive cells was investigated in this preliminary experimental study by laser scanning confocal microscopy. This approach represents an interesting and versatile tool to realize cellular staining in a defined module of lab-on-a-chip devices for subsequent detection and counting.     

Improving health communicationSupporting the practice of health communication

Background: Health authorities, hospitals, commercial enterprises, and mass media all deliver health and medical communication in different forms. With such a vast amount of biomedical and clinical information available, any action to ensure the spread of clinically relevant news items is welcome. Objectives: This paper tries to define a new role for health science librarians in improving medical communication and reporting. Methods: Literature relating to the health and medical reporting is analysed to identify major difficulties encountered by health communicators. Results: There are two areas where health science librarians can develop new roles in health communication: (i) supporting journalists and health communicators in selecting sources and understanding scientific papers, and (ii) directly translating scientific information into news items, supplying a list of products in this direction (i.e. targeted newsletters, media releases, news items). New skills and competencies needed to cope with the new roles are described in detail in a suggested academic curriculum for health communicators. Conclusions: A better understanding of the mass media's needs can provide much needed support in the field of health communication.