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71.
Europe hosts a significant number of global organizations in the transport market, the largest industrial R&D investor in the EU. The market contains a significant number of jobs, and thus, there is a need for learning solutions in its domain. One of the pillars for its expansion is advanced manufacturing technology. The EU Commission considers the implementation and development of this as one of its trans-sectoral ‘key enabling technologies’. This article presents a non-government ‘Sector Skills Alliance’—Skillman—that addresses advanced manufacturing technology skill needs for the automotive, aerospace and train industries. Funded by the EU, Skillman connects companies and organizations in terms of scope of action, size, field of expertise and legal framework including, in particular, industry leaders, research centres, accreditation bodies and TVET providers. Jaguar Land Rover, FIAT-FCA and SAS, Scandinavian Airlines Systems are just some of the organizations that worked together to find solutions to skills mismatches and challenges the sector faces finding the right skills. This article analyses challenges associated with skills mismatch and solutions proposed by Skillman to help transitions to work after training. The article clarifies the processes behind the Alliance creation (starting from the EU Copenhagen Declaration), the aims and nature of the Alliance, the strategic tools implemented by Skillman, as well as its challenges and first results. The article also argues that the Skillman Alliance has the right characteristics to meet skills requirements and can be used as a model approach for easing the transition from training to work.  相似文献   
72.
The efficiency of a long-span structure relies on how material is locally distributed within a fixed structural shape. In this paper a design procedure for thin plates made of three layers of a depleted material subject to a distributed vertical load is proposed. The investigation is driven by the idea of the optimal material organization and has the objective of maximizing the overall stiffness/weight ratio of the structure. Two microstructural architectures of the media are considered: a porous solid structure and a truss arrangement. For each type of microstructure the flexural stiffness has been correlated to the level of depletion by the use of a power law function by setting very few parameters. Finally, invoking the principles of structural homogenization theory, the global flexural response of the plate has also been calculated. The validity of the method is demonstrated by comparing the analytical results with those obtained by a numerical finite element simulation of the structure based on a detailed model of the media.  相似文献   
73.
The cytology of 130 indeterminate nodules (Thy 3) was retrospectively reviewed according to the British Thyroid Association 2014 classification. Nodules were divided into Thy 3a (atypical features) and Thy 3f (follicular lesion) categories. Histology was available as a reference for 97 nodules. Pre-surgical evaluations comprised biochemical tests, color-Doppler ultrasonography (US), semi-quantitative elastography-US (USE), contrast-enhanced US (CEUS), and mutation analysis from cytological slides. Thyroid malignancy was the final diagnosis for 19% of surgically-treated nodules. No statistically significant difference in the risk of malignancy was found between Thy 3a (26%) and Thy 3f (14%) nodules. Histology of the Thy 3a and Thy 3f nodules showed a higher incidence of Hurtle cell adenomas in Thy 3f (29%) than in Thy 3a (3%) nodules (P=0.01). The only pre-surgical difference concerned the BRAF V600E mutation, which was positive in some Thy 3a but not in any Thy 3f nodules (P=0.04). Receiver-operating characteristic (ROC) analysis was used to obtain cut-off values from US (score), USE (ELX 2/1 strain index), and CEUS (time-topeak index and peak index) data. The cut-off values were similar for Thy 3a and Thy 3f nodules. Data showed that malignancy can be suspected if the US score is >2, ELX 1/2 strain index >1, time-to-peak index >1, and peak index <1. In a sub-group of 24 revised nodules (12 Thy 3a and 12 Thy 3f) with histology as a reference, the diagnostic power of cumulative pre-surgical analysis by means of US, USE, and CEUS showed high positive and negative predictive values (83% and 100%, respectively) for the presence of malignancy in Thy 3a and Thy 3f nodules. In conclusion, in our series of revised Thy 3 nodules, malignancy was low and displayed no significant differences between Thy 3a and Thy 3f categories. The use of cut-offs based on histology as a reference could reduce surgery. Our data support the conviction that, in mutation-negative Thy 3a and Thy 3f nodules, observation should be the first choice when not all instrumental results are suspect.  相似文献   
74.
Director of the National Office of Didactic Centres, Italian Department of Public Instruction. Founding director of the European Education Centre at Frascati (1959–74). Author of numerous publications on education in the world, notably the three volumes of Invisible Capital(1975–81).  相似文献   
75.
76.
Central administrative services have recently received increasing attention from practitioners and academics due to the challenging need to both manage scarce resources and provide high-quality services. In this context, performance measurement systems (PMSs) may assume a central role, although an unresolved debate remains on the claimed benefits of accountability and the difficulties that have emerged in defining and managing proper measures. This paper contributes to this debate by presenting the results of a study in which a PMS for central administrative services has been developed and tested through an action research approach drawing on actor network theory. The experiment was carried out in 15 Italian universities and five areas of services were dealt with: student support, research support, accounting, human resources, and logistics and procurement. The highly participative method resulted in a comparable system with a complete set of cost and quality indicators across the participating universities. These data proved to be useful at managerial and policy level, providing insights on the presence of scale effects and on the relative importance of quality dimensions for users of services. Participating in the project encouraged the university staff to use indicators in decision making.  相似文献   
77.
In Italy, data and information on prevalence and characteristics of elder abuse are very limited, and a specific legal and policy framework is lacking. Some articles of the Penal Code refer to the larger context of violence against disadvantaged groups, and some general support services not specifically dedicated to this issue are managed by local municipalities. In this context, empirical research is useful for disseminating information and implementation of good practices. Such research indicates future directions for the education of the public and training of professionals on the prevention, detection, and treatment of abusive practices.  相似文献   
78.
Abstract

High-level physical performance in rhythmic gymnastics is influenced by numerous skills and anthropometric factors. In order to understand if genetic predisposition could play a role to define the elite rhythmic gymnast phenotype, we analysed the frequency of common polymorphisms linked to genes correlated with body mass (ADRB2 and FTO), explosive strength (ACTN3 and ACE), and joint mobility (COL5A1), in 42 gymnasts involved in National and International events, and in 42 control girls. Our results demonstrated that high-level rhythmic gymnasts constituted a genetically selected population showing higher frequency of: (a) ADRB2 and FTO alleles linked to low body mass index and low fat mass; (b) COL5A1 CT genotype linked to high joint mobility and to the occurrence of genu recurvatum, but also to a higher incidence of injuries. ACTN3 and ACE polymorphisms did not appear to be connected with the phenotype of high-level rhythmic gymnast. Based on these data, it can be assumed that these polymorphisms could positively affect the phenotype and performance of gymnasts.  相似文献   
79.
Higher education systems in competitive environments generally present top universities, that are able to attract top scientists, top students and public and private financing, with notable socio-economic benefits in their region. The same does not hold true for non-competitive systems. In this study we will measure the dispersion of research performance within and between universities in the Italian university system, typically non-competitive. We will also investigate the level of correlation that occurs between performance in research and its dispersion in universities. The findings may represent a first benchmark for similar studies in other nations. Furthermore, they lead to policy indications, questioning the effectiveness of selective funding of universities based on national research assessment exercises. The field of observation is composed of all Italian universities active in the hard sciences. Research performance will be evaluated using a bibliometric approach, through publications indexed in the Web of Science between 2004 and 2008.  相似文献   
80.

Introduction

The study of cardiac response to strenuous and continuous exercise is crucial to understanding the physiology of endurance. N-terminal proB-type natriuretic peptide (NT-proBNP) is a potential marker for monitoring myocardial wall stress, and troponins (TnT and TnI) are widely used in the diagnosis of cardiac ischemia and infarction. Strenuous exercise may generate transitory ischemia, myocardial stress, and diastolic left ventricular dysfunction, inducing the increased production of both these biomarkers. We measured changes in NT-proBNP and TnT in elite cyclists during a 3-week stage race, a model of strenuous exercise.

Materials and methods:

The study population was 9 professional cyclists participating in the 2011 Giro d’Italia. Pre-analytical and analytical phases scrupulously followed official recommendations. Anthropometric data, net energy expenditure and cardiac indexes (rate, diastolic and systolic blood pressure) were recorded. Blood samples were drawn pre-race (day −1) and at days 12 and 22; NT-proBNP and highly sensitive-troponin (Hs-TnT) concentrations were assayed and corrected for plasma volume changes.

Results:

Body-mass index decreased and energy expenditure increased by 52% during the race. NT-proBNP concentrations increased [day −1: 23.52 ng/L (9.67–34.33); day 12: 63.46 ng/L (22.15–93.31); P = 0.039; day 22: 89.26 ng/L (34.66–129.78) vs. day −1; P < 0.001] and correlated with heart rate (r = −0.51; P = 0.006), systolic pressure (r = 0.39; P = 0.046) and energy expenditure (r = 0.70; P < 0.001). TnT concentrations did not vary, but a widened TnT amplitude distribution was observed.

Conclusions:

Increases in NT-proBNP correlated with higher energy expenditure over a 3-week cycling stage race, possibly indicating myocardial stress.  相似文献   
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