Language and reading impairments are associated with increased prevalence of non-right-handedness

Handedness has been studied for association with language-related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non-right-handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex-matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta-analysis (N_cases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.     

Disambiguation and co-authorship networks of the U.S. patent inventor database (1975–2010)

Research into invention, innovation policy, and technology strategy can greatly benefit from an accurate understanding of inventor careers. The United States Patent and Trademark Office does not provide unique inventor identifiers, however, making large-scale studies challenging. Many scholars of innovation have implemented ad-hoc disambiguation methods based on string similarity thresholds and string comparison matching; such methods have been shown to be vulnerable to a number of problems that can adversely affect research results. The authors address this issue contributing (1) an application of the Author-ity disambiguation approach (0170 and 0175) to the US utility patent database, (2) a new iterative blocking scheme that expands the match space of this algorithm while maintaining scalability, (3) a public posting of the algorithm and code, and (4) a public posting of the results of the algorithm in the form of a database of inventors and their associated patents. The paper provides an overview of the disambiguation method, assesses its accuracy, and calculates network measures based on co-authorship and collaboration variables. It illustrates the potential for large-scale innovation studies across time and space with visualizations of inventor mobility across the United States. The complete input and results data from the original disambiguation are available at (http://dvn.iq.harvard.edu/dvn/dv/patent); revised data described here are at (http://funglab.berkeley.edu/pub/disamb_no_postpolishing.csv); original and revised code is available at (https://github.com/funginstitute/disambiguator); visualizations of inventor mobility are at (http://funglab.berkeley.edu/mobility/).     

Biochemical Evaluation of Patients of Alcoholic Liver Disease and Non-alcoholic Liver Disease

Alcoholic liver disease (ALD) is due to excessive alcohol intake for long duration. Distinguishing ALD from non-ALD (non-alcoholic steatohepatitis, hepatitis of viral origin) is difficult as patient may deny alcohol abuse. Clinical examination, histology and serology may not differentiate these conditions. Accurate diagnosis is important as management of ALD differs from non-ALD patients. The aim of our study was (1) To evaluate the patients of ALD and non-ALD by biochemical parameters compared to controls, (2) To assess whether these parameters can differentiate ALD from non-ALD. Study was carried out on 50 patients of ALD in group I and 35 patients of NASH (non-alcoholic steatohepatitis) and acute viral hepatitis each in group II. Age matched healthy controls n = 50. Selection criteria—history of alcohol intake (amount and duration), clinical examination, sonography of abdomen, serum alanine transaminase (ALT) and bilirubin levels. Blood samples were analyzed for bilirubin, aspartate transaminase (AST), ALT, alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) by kinetic method. Statistical analysis was done by Student unpaired ‘t’ test. Patients of ALD have raised AST/ALT ratio (De Ritis ratio) (>2), ALP and GGT compared to controls (P < 0.01).There is significant difference in AST/ALT ratio, serum GGT and ALP in ALD group compared to that in NASH and acute viral hepatitis (P < 0.05). This study suggests that De Ritis ratio >2 in ALD patients may be due to alcohol induced hepatic mitochondrial injury and pyridoxine deficiency. High GGT and ALP values may indicate enzyme induction by alcohol and mild cholestasis. Thus ALD patients have severe hepatic damage. De Ritis ratio <1 and normal to mild elevation in GGT level in NASH and acute viral hepatitis suggest mild hepatic injury of non-alcoholic origin. Our study concludes that ALD patients can be differentiated from NASH and acute viral hepatitis with certainty by measuring serum AST/ALT ratio, GGT and ALP. These biochemical parameters may help clinicians to support the diagnosis of ALD and non-ALD.