“铜与硝酸反应的装置设计”教学案例

1 教学设计的指导思想在三种版本(鲁教、苏教、人教)的必修1教材中都介绍了铜与浓、稀硝酸的反应,但引导学生形成知识的演示实验各不相同.人教版教材没有演示实验,苏教版教材用分液漏斗与试管作为反应的容器、将生成的气体通入水中收集完成性质实验,鲁教版用铜与硝酸反应的试管口上加蘸氢氧化钠的棉花设计完成实验,这二种教材演示实验设计都不利于学生近距离的观察,且教师重点强调NO、NO2毒性,使学生产生学习化学的畏惧感,造成教师上课一演示实验,学生赶紧捏鼻子逃避的现象,教材的实验教学功能被减弱.     

刚柔相宜的和谐之美—试论儒家文化对太极拳的浸润作用

儒家文化作为中华传统文化的核心和主导,潜移默化地渗透到社会生活的方方面面。作为中国国粹的太极拳,不仅是一个体育项目,更是传承传统文化的一个载体。因此,太极拳在产生与发展的过程中势必会受到儒家文化对它的浸润,从而呈现出儒家的文化特色与精神实质。     

"梦诗":陆游爱国情怀的另一种表达

分析陆游“梦诗”中所表现出来的深沉的爱国意蕴,解读他在苟安于一隅的南宋朝廷统治下虽无法实现光复国土的伟大抱负却始终抱有心系祖国安危、民族复兴的高尚情怀。“梦诗”的笔调是浪漫的,也是悲愤的;“梦诗”的内容有虚构的,更多的却是纪实。在“梦”这一荒诞的形式中流露出来的是陆游终身无法释怀的爱国情结。     

语境系统的范畴化解析

文章借鉴范畴化理论相关内容,在徐思益先生语言理论的基础上,对语境整体作了系统、简明地概括。将语境概括为语义语境与语用语境两大核心范畴,语用语境分为必要语境与特定语境,必要语境是典型成员,特定语境是其延伸。     

影响职业体育的地理学因素分析

职业体育是一种非常特殊的经济行为,其发展有着其自己的客观规律。许多事实证明,职业体育的发展与地理环境有着密不可分的关系。研究结果表明:职业体育的体育发展不仅受到自然地理因素———主要是气候、海拔等因素的影响,更重要的是受到人文地理———例如区域经济发展水平、消费水平等因素的影响。本文试图分析影响职业体育的地理学因素,为职业体育的良性发展提供理论和实践依据。     

工科专业实验室人性化、精细化管理实践

针对高校从事能源领域科学研究和辅助教学的专业实验室的管理问题,提出了人性化、精细化的管理理念与模式,着重在人力资源的深度挖掘和优化配置、对外开放与功能拓展、支撑实验教学和人才培养、精细化与人性化管理等方面,开展了积极探索.通过实践,为实验室的科学管理和持续发展积累了宝贵经验.     

赌球法律问题探讨

在分析我国现存的赌球表现方式和社会危害性的基础上,从刑法学角度对赌球行为是否构成犯罪进行解析,认为赌球破坏足球联赛秩序及水平、破坏社会公共秩序、扰乱国内金融秩序.基于目前我国相关法律条款有无相关的规定,众多法官评判依据的释义,对赌球行为的不同情况予以法律学罪名的界定,明确其适用具体的法律规定.     

对日、韩、朝男足传抢特点及应对策略的研究

以第16届亚运会日本、韩国和朝鲜男子足球队所参加的决赛阶段比赛为研究对象,选取球队传球和抢断球的次数作为球队进攻和防守能力的指标,球队核心球员传球方向的次数、成功率和比例作为球队技战术特征的指标进行数据统计和分析,以期为我国男子足球队在今后比赛中能够更好地应对对手提供理论依据。     

基于项目驱动的高职《电子CAD》课程教学改革与实践

高职电子CAD课程教学改革立足于增强教学过程的实践性和职业性,以电子电路中典型的电路为实例,采用项目化教学,坚持知识目标与技能目标并重。优化课程结构、整合教学内容、改革教学方法与教学手段是改革的关键,也是实现教学目标的重要途径。     

Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A–Smad2/3 in rats following myocardial infarction

PurposeThe aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1 (FSTL1), which may induce cardioprotection in rats following myocardial infarction (MI) by inducing angiogenesis.MethodsMale, adult Sprague-Dawley rats were randomly divided into 5 groups (n = 12 in each group): sham group (S), sedentary MI group (MI), MI + resistance exercise group (MR), MI + adeno-associated virus (AAV)–FSTL1 injection group (MA), and MI + AAV–FSTL1 injection + resistance exercise group (MAR). The AAV–FSTL1 vector was prepared by molecular biology methods and injected into the anterior tibialis muscle. The MI model was established by ligation of the left anterior descending coronary artery. Rats in the MR and MAR groups underwent 4 weeks of dynamic resistance exercise training using a weighted climbing-up ladder. Heart function was evaluated by hemodynamic measures. Collagen volume fraction of myocardium was observed and analyzed by Masson''s staining. Human umbilical vein vessel endothelial cells culture and recombinant human FSTL1 protein or transforming growth factor-β receptor 1 (TGFβR1) inhibitor treatment were used to elucidate the molecular signaling mechanism of FSTL1. Angiogenesis, cell proliferation, and disco interacting protein 2 homolog A (DIP2A) location were observed by immunofluorescence staining. The expression of FSTL1, DIP2A, and the activation of signaling pathways were detected by Western blotting. Angiogenesis of endothelial cells was observed by tubule experiment. One-way analysis of variance and Student''s t test were used for statistical analysis.ResultsResistance exercise stimulated the secretion of skeletal muscle FSTL1, which promoted myocardial angiogenesis, inhibited pathological remodeling, and protected cardiac function in MI rats. Exercise facilitated skeletal muscle FSTL1 to play a role in protecting the heart. Exogenous FSTL1 promoted the human umbilical vein vessel endothelial cells proliferation and up-regulated the expression of DIP2A, while TGFβR1 inhibitor intervention down-regulated the phosphorylation level of Smad2/3 and the expression of vascular endothelial growth factor-A, which was not conducive to angiogenesis. FSTL1 bound to the receptor, DIP2A, to regulate angiogenesis mainly through the Smad2/3 signaling pathway. FSTL1–DIP2A directly activated Smad2/3 and was not affected by TGFβR1.ConclusionDynamic resistance exercise stimulates the expression of skeletal muscle-derived FSTL1, which could supplement the insufficiency of cardiac FSTL1 and promote cardiac rehabilitation through the DIP2A–Smad2/3 signaling pathway in MI rats.