Coherence: the comprehension and production abilities of college writers who are normally achieving, learning disabled, and underprepared

The ability to understand and produce coherent text structure was assessed across three groups of college writers, normally achieving, learning disabled, and underprepared. It was found that college writers with learning disabilities were more like the normally achieving writers on an assessment of comprehension of text structure. On the production of a coherent text, normally achieving writers performed better than either of the other groups, but the writers with learning disabilities (LD) performed better than the underprepared writers. These results suggest that the writers with LD demonstrate greater discrepancies between their comprehension and production of written form than either of the other groups. The writers with LD appear to understand text structure like normally achieving writers but, like the underprepared writers, they experience difficulty in the production processes.     

Timed essay writing: implications for high-stakes tests

The majority of high-stakes tests from elementary school through postsecondary education include the timed impromptu essay as a measure of writing performance. For adolescents with writing disorders, this type of evaluation often presents a significant barrier. The purpose of the current study was twofold. First, we investigated the influence of handwritten, typed, and typed/edited formats of an expository essay on the quality scores received by students with (n = 65) and without (n = 65) dyslexia. Second, we examined the contribution of spelling, handwriting, fluency, and vocabulary complexity to the quality scores that students with and without dyslexia received on the same writing task. Analyses indicated that vocabulary complexity, verbosity, spelling, and handwriting accounted for more variance in essay quality scores for writers with dyslexia than for their typically achieving peers. Both group and individual student outcomes are reported to better understand the needs of struggling writers with dyslexia. Implications for assessment, instruction, and accommodations are discussed with an eye toward reform efforts that target improved teaching and learning.     

Like Father, Like Son: Young Children's Understanding of How and Why Offspring Resemble Their Parents

4 studies investigated the broad claim that preschoolers understand biological inheritance. In Study 1, 4–7-year-old children were told a story in which a boy was born to one man and adopted by another. The biological father was described as having one set of features (e.g., green eyes) and the adoptive father as having another (e.g., brown eyes). Subjects were asked which man the boy would resemble when he grew up. Preschoolers showed little understanding that selective chains of processes mediate resemblance to parents. It was not until age 7 that children substantially associated the boy with his biological father on physical features and his adoptive father on beliefs. That is, it was not until age 7 that children demonstrated that they understood birth as part of a process selectively mediating the acquisition of physical traits and learning or nurturance as mediating the acquisition of beliefs. In Study 2, subjects were asked whether, as a boy grew up, various of his features could change. Children generally shared our adult intuitions, indicating that their failure in Study 1 was not due to their having a different sense of what features can change. Studies 3 and 4 replicated Study 1, with stories involving mothers instead of fathers and with lessened task demands. Taken together, the results of the 4 studies refute the claim that preschoolers understand biological inheritance. The findings are discussed in terms of whether children understand biology as an autonomous cognitive domain.     

Toward expediting the resolution of debates in the social sciences 1

Four reasons for the prevalent delays in resolving debates in the social sciences are discussed. These are the difficulty in clearly answering certain questions for investigation, the inadequacy of common research designs for establishing “firm inferences,”; the lack of methods for reviewing and synthesizing disparate results from different studies of the same topic, and the inappropriateness of present debate arenas for expediting resolution. Some characteristics of the arenas of social science debates are described, and several suggestions for improving these arenas are proposed.     

Privileged Identity Exploration: Examining Counselor Trainees' Reactions to Difficult Dialogues

In this qualitative study, the authors examined master's‐level counselor trainees' reactions to difficult dialogues in the classroom regarding racism, heterosexism/homophobia, and ableism over a 3‐year period. Using the Consensual Qualitative Research method as introduced by C. E. Hill, B. J. Thompson, and E. N. Williams (1997), the data analysis team analyzed narrative and reaction papers submitted during a didactic course on multiculturalism. Behavioral reactions were identified that form the basis for this study: denial, deflection, rationalization, intellectualization, principium, false envy, minimization, and benevolence.     

低氧诱导因子与乳腺癌转移

概肿瘤,特别是实体瘤,其内部微环境处于一种低氧或缺氧的状态,肿瘤的这种低氧微环境将诱导活化低氧诱导因子（HIF-1）信号通路。HIF-1信号通路在乳腺癌的转移中发挥着重要的作用。乳腺癌的转移涉及肿瘤细胞的浸润、进入血管、通过血液循环迁移、到达远端毛细血管内壁、穿透血管壁进入新的器官以及在新的部位形成转移灶等步骤,过程非常复杂。本文重点围绕 HIF-1在转移各个步骤中的作用进行综述。