粤西士人与粤西文化建设与发展——"粤西士人研究"之二

东汉末年,在粤西士人的努力下,交趾改称交州,与全国十三刺史部一样同称为州,建制的升格,意味着越、汉一体化的新进程.东汉末年,苍梧太守牟子博撰作<理惑论>,这部佛教史上我国现存最早的佛教撰述之所以出现在交州,就是因为其地理位置,因其偏远,中原人士避乱至此,带来了各种学术思想的交锋、交流;因其偏远却与海外交通便利,较先接近海外学术.粤西文化建设,又是在外籍人士远赴粤西任职为宦者与本土少数民族"酋领"的共同努力下发展的.     

思想政治教育学科共同体探析

科学共同体作为共同体的一种专业、职业联合体,对于现代学科的发展具有直接借鉴意义。思想政治教育学科共同体在科学共同体的意义上理解和塑造,并依据身份认同、共有理解、共同信念、总体方法论四个基本维度做出进一步的分析,以期摆脱被泛化的尴尬,在基本理论、基本范畴上更深层反映思想政治教育学科的丰富性。     

高校思想政治理论课的价值论

知识教育和信仰教育是思想政治理论课教学中两个重要环节,二者相互促进,不可偏废。知识教育是信仰教育的原生形态,是信仰教育的逻辑表现形式;信仰教育是知识教育的价值取向,是知识教育的最终目的。思想政治理论课教学应该坚持知识教育统一于信仰教育的原则,经由知识教育层面上升到信仰教育层面。     

Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways

Mesenchymal stem cell(MSC)transplantation has shown a therapeutic potential to repair the ischemic and infracted myocardium,but the effects are limited by the apoptosis and loss of donor cells in host cardiac microenvironment.The aim of this study is to explore the cytoprotection of heat shock protein 90(Hsp90)against hypoxia and serum deprivation-induced apoptosis and the possible mechanisms in rat MSCs.Cell viability was determined by3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Apoptosis was assessed by Hoechst 33258nuclear staining and flow cytometric analysis with annexin V/PI staining.The gene expression of Toll-like receptor-4(TLR-4)and V-erb-b2 erythroblastic leukemia viral oncogene homolog 2(ErbB2)was detected by real-time polymerase chain reaction(PCR).The protein levels of cleaved caspase-3,Bcl-2,Bcl-xL,Bax,total-ERK,phospho-ERK,totaI-Akt,phospho-Akt,and Hsp90 were detected by Western blot.The production of nitric oxide was measured by spectrophotometric assay.Hsp90 improves MSC viability and protects MSCs against apoptosis induced by serum deprivation and hypoxia.The protective role of Hsp90 not only elevates Bcl-2/Bax and Bcl-xL/Bax expression and attenuates cleaved caspase-3 expression via down-regulating membrane TLR-4 and ErbB2 receptors and then activating their downstream PI3K/Akt and ERK1/2 pathways,but also enhances the paracrine effect of MSCs.These findings demonstrated a novel and effective treatment strategy against MSC apoptosis in cell transplantation.     

Neurochip based on light-addressable potentiometric sensor with wavelet transform de-noising

Neurochip based on light-addressable potentiometric sensor(LAPS),whose sensing elements are excitable cells,can monitor electrophysiological properties of cultured neuron networks with cellular signals well analyzed.Here we report a kind of neurochip with rat pheochromocytoma(PC12) cells hybrid with LAPS and a method of de-noising signals based on wavelet transform.Cells were cultured on LAPS for several days to form networks,and we then used LAPS system to detect the extracellular potentials with signals d...     

Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients

Objective  

The purpose of this study was to determine the unique and universal features of microsatellite instability-high (MSI-H) colorectal cancer (CRC) and MSI-H gastric cancer (GC) in the Chinese population.     

Chewing substances with or without tobacco and risk of cardiovascular disease in Asia: a meta-analysis

Objective  

To assess whether people who ever use any form of chewing substance in Asia are at increased risk of cardiovascular disease (CVD).     

A facile approach to construct hybrid multi-shell calcium phosphate gene particles

The calcium phosphate (CaP) particles have attracted much attention in gene therapy. How to construct stable gene particles was the determining factor. In this study,hybrid multi-shell CaP gene particles were successfully constructed. First,CaP nanoparticles served as a core and were coated with DNA for colloidal stabilization. The ξ-potential of DNA-coated CaP nanoparticles was -15 mV. Then polyethylenimine (PEI) was added and adsorbed outside of the DNA layer due to the electrostatic attraction. The ξ-pot...     

利用GSM短消息实现热计量表远程无线抄表系统的设计

针对居民供暖系统采用分户控制、分户计量之后带来的抄表问题,提出利用GSM短消息设计热计量表远程无线抄表系统的方案.给出了系统的总体设计思路以及具体的软硬件设计方案,通过该系统实现了热计量表的远程无线抄表.     

Exploring the global significance of Chinese education: A new start for <Emphasis Type="Italic">Frontiers of Education in China</Emphasis>

Editorial

Exploring the global significance of Chinese education: A new start for Frontiers of Education in China