Methylenetetrahydrofolate reductase C677T polymorphism predicts response and time to progression to gemcitabine-based chemotherapy for advanced non-small cell lung cancer in a Chinese Han population

Objective:The aim of this study was to evaluate the association between the methylenetetrahydrofolate reductase(MTHFR) C677T excision repair cross-complementation group 1(ERCC1) genetic polymorphisms and the clinical efficacy of gemcitabine-based chemotherapy in advanced non-small cell lung cancer(NSCLC).Methods:A total of 135 chemonaive patients with unresectable advanced NSCLC were treated with gemcitabine/platinum regimens.The polymorphisms of MTHFR C677T,ERCC1 C8092A,and ERCC1 C118T were genotyped using the TaqMan methods.Results:The overall response rate was 28.9%.Patients with MTHFR CC genotype had a higher rate of objective response than patients with variant genotype(TT or CT)(41.2% versus 19.1%,P=0.01).Median time to progression(TTP) of patients with MTHFR CC genotype was longer than that of patients with variant genotype(7.6 months versus 5.0 months,P=0.003).No significant associations were obtained between ERCC1 C118T and C8092A polymorphisms and both response and survival.Conclusions:Our data suggest the value of MTHFR C677T polymorphism as a possible predictive marker of response and TTP in advanced NSCLC patients treated with gemcitabine/platinum.     

基于冗余字典的高光谱图像的稀疏分解

基于冗余字典的稀疏表示方式能够以较少的数据量,更好地描述高光谱图像中的特征信息,是一种更有效的高光谱图像表示方法。根据高光谱图像自身的特点,使用梯度下降法学习冗余字典,首先固定字典,用梯度下降法训练系数;然后固定系数,再用同样的方法训练字典,以上两步交替进行,直到算法收敛;最后将这个字典用于高光谱图像的重构。实验结果表明,该方法获得了良好的重构效果。     

读者决策采购——为用付费——一种新兴的文献资源建设模式

简要介绍了读者决策采购模式的概念和发展,在分析我国高校图书馆文献资源读者荐购模式的基础上,结合读者决策采购模式的优势,提出了该模式在国内高校图书馆的应用前景。     

The Effects of Attachment Styles and Efficacy of Communication on Avoidance Following a Relational Partner's Deception

This investigation examined the effects of attachment styles and efficacy of communication on avoidance following a relational partner's deceptive communication. Efficacy of communication was explored as a mediating variable. Students (n = 123) who reported being deceived by their relational partner were recruited for the study. The data revealed that, compared to individuals with other attachment styles, those with a high anxious/ambivalent attachment tendency were more likely to avoid discussing the deception with their partner. In addition, efficacy of communication was negatively associated with avoidance. The results further revealed, however, that efficacy of communication mediated the link between attachment and avoidance. More specifically, highly anxious/ambivalent individuals were more likely to perceive relatively low efficacy of communication, and such perception, in turn, influenced their avoidance. Findings of the study provide an explanation for the association between attachment and avoidance.     

高校计算机实验室硬件和软件管理方法

高校计算机实验室其主要作用为进行计算机实验教学、培养专业人才,开展科学研究的重要基地。因此高校计算机实验室管理与维护工作是高校教学和实验的重要组成部分。高校计算机实验室主要承担教学、考试和科研任务,其综合管理水平的高低,是衡量学校办学水平高低的重要指标之一。本人结合多年来从事高校计算机实验室的工作经验,坚持科学的管理计算机实验室,使得计算机系统和软件每次使用前都处于完好、安全、稳定的状态下,为实验室教学、考试和科研任务提供了可靠的保证。     

回文结构中的“事件性”分析

回文是英汉语中一种常见又具有平衡美的修辞手法。本文旨在心智哲学视角下对回文结构中存在的"事件性"进行分析,从而为回文结构的理解提供一个全新的视角。回文的基本句式表达的是一种"事件",而其回返往复的效果则是在"事件"基础上通过主体的意向性和反思意识并结合语境而涌现成为的不同的"用例事件"。     

独立学院大学英语课堂合作学习模式调查与研究

本研究以合作学习理论为基础,通过学生英语水平调查;学生合作学习情况综合调查;教师在合作学习中的角色定位;有效的考核方式四个方面探讨了独立学院大学英语课堂合作学习的情况,试图找到在大学英语课堂中实施合作学习的有效途径。     

从话语分析的角度看英文平面广告劝诱力的实现——解读广告中作者和读者身份及相互关系的建构

本文从话语分析的角度解构一则英文平面广告,以此探析英文广告如何通过建构作者和读者身份及二者亲密的私人关系来实现广告的劝诱力。以此帮助消费者深入理解广告,理性消费;方便外贸企业为外销产品(含服务)打造更有力的促销"武器"。     

民族地区信息技术与大学英语课程整合的改进策略

信息技术与课程整合理论对传统教学改革的指导作用毋庸置疑,多媒体教学以及网络学习平台作为现阶段信息技术与课程整合的重要实现方式已得到普及和推广,甚至曾一度达到痴迷的程度。然而笔者调研了五所民族地区大学英语与信息技术整合的现状,发现在少数民族语言授课班级和音体美特长班的多媒体教学中存在诸多问题,笔者针对这些问题提出一些改进的策略,以期望能使信息技术作为学生学习的有效工具,进而培养学生的信息技术素养。     

谈冰球运动员的身体训练

身体训练是指在运动过程中,运用各种身体练习,有效地影响运动员身体形态的变化,从而增进运动员身体健康,提高有机体机能和发展运动素质的训练。