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L. Hema Bindu P. Usha Rani P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2007,22(2):32-35
Calcineurin, a Ca2+—Calmodulin dependent protein phosphatase, is important for Ca2+ mediated signal transduction. The main objective of this study was to examine the potential role of calcineurin in idiopathic
mental handicap. Calcineurin levels were estimated in 20 children in the age group of 5–16 years with idiopathic mental handicap
attending the Special. Education Centre for the Mentally Handicapped in Hyderabad. The results of the present study showed
decreased activity of serum calcineurin in children with idiopathic mental handicap compared to those of normal subjects in
the same age group. The observations thus suggest impaired calcineurin activity in children with mental handicap. Calcineurin
that is involved in biosynthesis and release of neurotransmitters at the synaptic terminal brain is affected thereby causing
brain damage and leading to mental handicap. Impaired calcineurin activity was already indicated in many human diseases such
as Down's syndrome, Alzheimers, Brain ischemia, cardiac hypertrophy etc. It is therefore necessary to check the calcineurin
levels in children with mental handicap to understand the role of calcineurin in the causation of Mental handicap. 相似文献
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Riana E. Anderson Shawn C.T. Jones Farzana T. Saleem Isha Metzger Nkemka Anyiwo Kyle Simone Nisbeth Kiana D. Bess Kenneth Resnicow Howard C. Stevenson 《Child development》2021,92(6):2375-2394
Racial discrimination can lead to psychosocial problems for Black adolescents, including internalization (e.g., depression) and externalization (e.g., conduct problems). Black parents (N = 186; Mage = 42.9) of adolescents (ages 10–18) were assessed to investigate how parental worries and racial socialization competency (i.e., confidence, skills, and stress) contribute to the association between parental discrimination experiences and their adolescents’ psychosocial problems. Mediation analyses indicated that the total direct models with discrimination, worries, and problems had good fit, and that the addition of worry mediated the discrimination-problems association. Furthermore, racial socialization competency moderated the association between worry and problems, wherein greater competency was associated with less impact of worry on problems. Findings illuminate potential intervention targets for buffering discrimination’s influence on adolescents’ psychosocial functioning. 相似文献
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Rani James G. Ramesh Lakshmi Krishnamoorthy Rahul Bhagat Shilpa Chadaga Vijayalaxmi Deshmane Girija Ramaswamy 《Indian journal of clinical biochemistry : IJCB》2014,29(1):21-28
Vascular endothelial growth factor (VEGF) plays an important role in the development of Breast Cancer. The aim of this study was to investigate the association of polymorphisms in the VEGF gene on prognosis of Breast Cancer patients. This study comprised 200 patients with histologically confirmed cases of Breast cancer and 200 controls. Genotyping of the VEGF gene polymorphisms at +405G>C,−1154G>A, were performed by PCR-RFLP analysis. Preoperative plasma VEGF levels were determined by ELISA. Amongst both cases and controls, the genotypic distribution of the individual SNPs were all in Hardy–Weinberg equilibrium. Mean VEGF level was significantly elevated in cases compared to controls (t = 8.248; P < 0.001). No significant association was found between +405G>C,−1154G>A VEGF polymorphism and Breast Cancer. Logistic regression analysis revealed that 405GG & 1154GG were associated with higher levels of VEGF. 相似文献
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Education and Information Technologies - Wearable devices are a popular class of portable ubiquitous technology. These devices are available in a variety of forms, ranging from smart glasses to... 相似文献
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The currently influential model for information and communication technologies for development (ICT4D) is based on increasing the well-being of the poor through market-based solutions, and by using low-cost but advanced technologies. Using ethnographic methods, we chart out the contradictions that could arise when such a development-through-entrepreneurship model is implemented. We examine the Akshaya project, a franchise of computer-service kiosks in Kerala, India, which strives simultaneously for social development through access to computers and financial viability through cost recovery and entrepreneurship. We show that tensions within the state and among entrepreneurs and perceptions of public versus private among consumers make it challenging to meet the twin goals of commercial profitability and social development. 相似文献
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G. Suman Latha Vijaya Lakshmi H. Surekha Rani K. J. R. Murthy MD FCCP 《Indian journal of clinical biochemistry : IJCB》2005,20(2):170-173
The study was aimed at presence of specific IgE antibody levelsinvitro to the identified antigen. Based on positive skin test with Gynandropsis gynandra and elevated levels of total IgE (>325
IU/ml) 104 patients were selected. Healthy, asymptomatic individuals (25) with low total IgE (<325 IU/ml) were included as
controls. The mean OD values by ELISA for specific IgE were 0.67±0.21, 0.57±0.18 and 0.56±0.18 with whole pollen antigen,
46-37 kD fraction and 36-32 kD fraction, respectively. The specificity and sensitivity between skin test positivity with whole
pollen antigen verses fraction with mol.wt 46-37 kD was 90% and 90% and for fraction with mol.wt 36-32 kD was found to be
81.1% and 89.4%. The clusters with molecular weights 46-37 kD and 36-32 kD may be useful inin vitro diagnostic test. Fractions within these clusters need to be identified for a higher specificity. 相似文献
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Anmol Goyal Rajendra Prasad Parul Goel Amit Pal Suvarna Prasad Isha Rani 《Indian journal of clinical biochemistry : IJCB》2021,36(4):387
Coronavirus disease 2019 (Covid-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pandemic disease which has affected more than 6.2 million people globally, with numbers mounting considerably daily. However, till date, no specific treatment modalities are available for Covid-19 and also not much information is known about this disease. Recent studies have revealed that SARS-CoV-2 infection is associated with the generation of thrombosis and coagulopathy. Fundamentally, it has been believed that a diverse array of signalling pathways might be responsible for the activation of coagulation cascade during SARS-CoV-2 infection. Henceforth, a detailed understanding of these probable underlying molecular mechanistic pathways causing thrombosis in Covid-19 disease deserves an urgent exploration. Therefore, in this review, the hypothetical crosstalk between distinct signalling pathways including apoptosis, inflammation, hypoxia and angiogenesis attributable for the commencement of thrombotic events during SARS-CoV-2 infection has been addressed which might further unravel promising therapeutic targets in Covid-19 disease. 相似文献