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We investigated the oxygen-conserving potential of the human diving response by comparing trained breath-hold divers (BHDs) to non-divers (NDs) during simulated dynamic breath-holding (BH). Changes in haemodynamics [heart rate (HR), stroke volume (SV), cardiac output (CO)] and peripheral muscle oxygenation [oxyhaemoglobin ([HbO2]), deoxyhaemoglobin ([HHb]), total haemoglobin ([tHb]), tissue saturation index (TSI)] and peripheral oxygen saturation (SpO2) were continuously recorded during simulated dynamic BH. BHDs showed a breaking point in HR kinetics at mid-BH immediately preceding a more pronounced drop in HR (?0.86 bpm.%?1) while HR kinetics in NDs steadily decreased throughout BH (?0.47 bpm.%?1). By contrast, SV remained unchanged during BH in both groups (all > 0.05). Near-infrared spectroscopy (NIRS) results (mean ± SD) expressed as percentage changes from the initial values showed a lower [HHb] increase for BHDs than for NDs at the cessation of BH (+24.0 ± 10.1 vs. +39.2 ± 9.6%, respectively; < 0.05). As a result, BHDs showed a [tHb] drop that NDs did not at the end of BH (?7.3 ± 3.2 vs. ?3.0 ± 4.7%, respectively; < 0.05). The most striking finding of the present study was that BHDs presented an increase in oxygen-conserving efficiency due to substantial shifts in both cardiac and peripheral haemodynamics during simulated BH. In addition, the kinetic-based approach we used provides further credence to the concept of an “oxygen-conserving breaking point” in the human diving response.  相似文献   
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Over a decade after Napster’s introduction, file sharing programs still shoulder much of the blame for music and other media’s declining sales. Although labels and industry associations point their fingers at the harm digital piracy and file-sharing cause, they are less likely to admit the extent to which these anti-markets inform everyday decisions. File-sharing technologies create networks of users that serve as profitable data for ratings and metrics agencies. Using a case study of BigChampagne and its relationship to Napster, this article considers how the look, structure, and function of file-sharing software helped turn an economically threatening community into a commodity and how piracy’s disruptive potential is always in tension with processes of commodification.  相似文献   
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There is a widespread view held by health clinicians that their work effectiveness is impaired by 'information overload.' Building upon a previous work by Wilson, a review of the literature was undertaken to look for the evidence of this. It was found that the literature, particularly in the context of the clinical environment, was limited. This review explores the diverse overarching theories of information overload, effects of the phenomenon that are perceived to occur and proposed solutions to this problem. Many of the papers noted an information explosion but only three authors explicitly attempted to measure both the quantity and the complexity of this information. It was also found that the typology of the information studied was severely limited with most studies exploring information such as guidelines, access to journals, research findings and other knowledge intensive areas. Solutions proposed seem to concentrate on technological means rather than exploring the use of humans either in management of information or as a step in the filtering process.  相似文献   
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