促进教师专业化的数学教育实习改革研究

随着教师专业化进程的推进,作为数学教师专业成长起点的数学教育实习,目前还存在许多问题,对其改革势在必行。文章借鉴国外发达国家的教育实习做法,针对国内现状提出了改革策略,构建了四阶段教育实习模式：教育见习、模拟实习、正式实习、教育研习。     

职业教育学研究的未来范式——以问题为中心的跨学科研究

目前职业教育研究尚未形成共有"范式",研究者在不同的理论框架下讨论相同的问题时产生了很多分歧。范式对学科发展起到很大的推动作用,职业教育学研究也需要一个共同的研究模式,职业教育学学科建设关注职业教育实践问题的同时也要构建理论体系。无论从实践层面还是理论层面上看,以问题为中心的跨学科研究将成为职业教育学研究的未来范式。     

科技期刊页码编排的规范化问题

对2010年出版的120种科技期刊页码的编排情况进行调查。发现一些科技期刊页码的编排不符合GB/T 3179—2009《期刊编排格式》的规定。对科技期刊页码编排存在的问题进行分析,并提出相应建议。     

Standardization of a dilution method for cyclosporin (C2) estimation in renal transplant patients

Accurate monitoring of blood cyclosporin C2 levels is vital to prevent over immunosuppression and acute renal toxicity in patients who receive organ transplant. The matrix used to dilute patients’ C2 samples prior to the assay affected the final measured values. Hence there was a need to develop a method of dilution that would accurately estimate C2 levels when cyclosporin levels were beyond the calibration range of the method employed. Whole blood, cyclosporin free hemolysate and cell and protein free supernatant obtained after pretreatment of normal blood were used to dilute patients’ C2 samples. C2 was measured in 188 patients using the supernatant method of dilution. C2 was correlated with Co and dose of cyclosporin received by the patient. The use of cell and protein free supernatant obtained after pretreatment of normal blood as a C2 diluent detected higher levels of C2 in the sample. Measured C2 correlated significantly with Co and the cyclosporin dose received by the patient. The uniformly aqueous cell and protein free supernatant ensures uniform dilution of the patients’ C2 sample and measures higher cyclosporin levels.     

5－Br－PADAP作为配位滴定铅指示剂的研究

本文研究在ＰＨ５．５的六次甲基四胺缓冲体系中，以５－Ｂｒ－ＰＡＤＡＰ作为指示剂，用ＥＤＴＡ滴定铅精矿中铅含量。试验结果表明，终点变色敏锐，测定结果变异系数为０．２７％（ｎ＝５）。     

Comparative analyses for beta human chorionic gonadotropin

Serum Beta human chorionic gonadotropin (BhCG) was measured in 25 healthy controls and 75 cases with gestational trophoblastic neoplasms and testicular tumor using RIA kit from BARC, Bombay and ELISA kit from Abbott Diagnostics, USA. Regression Analysis of the values obtained for controls and cases by both the methods were statistically significant P 0.001.     

深圳住宅小区群众体育调查与研究

群众体育运动小区化代表着现代社会群众体育运动的一种发展趋势,深圳在这一方面一直走在全国的前列。本文运用社会学、经济学、体育学、统计学等基本理论和综合研究方法,通过问卷调查取得了大量的第一手研究资料,从不同的角度综合研究深圳住宅小区群众体育发展状况,在此基础上就住宅小区群众体育的发展提出相关建议。     

A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats

Radiation therapy has been widely applied in cancer treatment. However, it often causes thrombocytopenia (deficiency of white blood cells) as an adverse effect. Recombinant human interleukin-6 (rhIL-6) has been found to be a very effective way against this thrombocytopenia, but IL-6 has low stability in blood, which reduces its efficacy. To increases the stability and half-life of rhIL-6, it was modified by polyethylene glycol (PEG). The pharmacokinetics and the tissue distribution of PEG-rhIL-6 labeled with ¹²⁵I were examined after subcutaneous injection in rats. The pharmacokinetic pattern of PEG-rhIL-6 was defined with linear-kinetics, and we fitted a one-compartment model with half-lives of 10.44–11.37 h (absorption, t _{1/2K a}) and 19.77–21.53 h (elimination, t _1/2Ke), and peak concentrations at 20.51–21.96 h (t _peak) in rats. Half-lives and t _peak of PEG-rhIL-6 were longer than those of rhIL-6 previously reported. In the present study, for deposition of PEG-rhIL-6 in rats, the tissue distribution examination showed that blood was the major organ involved, rather than liver. However, as to the elimination of PEG-rhIL-6, the major organ was the kidney. The excretion fraction of the injection dose recovered from urine was 23.32% at 192 h after subcutaneous administration. Less than 6% of PEG-rhIL-6 was eliminated via the feces at 192 h. These results indicate that PEG-rhIL-6 is a good candidate drug formulation for patients with cancer.