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41.
Science museums play a role in creating visitor experiences that relate to contemporary issues in science, and in linking audiences to the scientific enterprise and the community of scientists. In the Portal to the Public approach, science researchers are trained by museum educators with experience in inquiry‐based learning, and are then given opportunities to translate their current research for museum audiences. Portal to the Public offers one solution to museums seeking to sustain a commitment to delivering experiences that reflect the dynamic pace of research, and the need to connect local communities to scientific research occurring in their midst. 相似文献
42.
Simbita A. Marwah Hitesh Shah Kiran Chauhan Amit Trivedi N. Haridas 《Indian journal of clinical biochemistry : IJCB》2014,29(2):161-166
Currently employed markers for the detection of acute coronary syndrome are Troponin T, CK (Creatine Kinase) and CKMB activity. CKMB activity measured by immunoinhibition method can give falsely elevated results due to the presence of atypical CK and CKBB and at times lead to the mis-diagnosis of acute coronary syndrome. Hence, CKMB mass (CKMB) measured by electrochemiluminence sandwich principle was employed. In this cross-sectional study 183 samples of 61 patients were analyzed within 6 h of diagnosis of acute coronary syndrome and followed up to 72 h. The correlation coefficient between CKMB activity and CKMBM at 4–6 h was 0.744, while at 12–24 h it was 0.909 and at 48–72 h it was 0.337. Thus there was good association between the two methods at 12–24 h but, statistically for method comparison studies and for replacing one method by another, the two methods need to be in agreement with one another. In this study the two methods are not in agreement with one another and thus analytically not replaceable. Another finding was obtained that CKMBM reached cut off levels prior to CKMB enzyme activity and hence, CKMBM is clinically better than CKMB activity to detect reinfarction. 相似文献
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Anuradha Bharosay Vivek V. Bharosay Debapriya Bandyopadhyay Ajoy Sodani Meena Varma Haren Baruah 《Indian journal of clinical biochemistry : IJCB》2014,29(3):372-376
Stroke is the third major cause of death worldwide. Elevated plasma concentration of low density lipoproteins and low plasma concentration of high density lipoprotein concentration are associated with an increased risk of atherosclerosis and coronary heart disease but the relation between serum lipids, and cerebrovascular disease is less clear. The aim of this study was to investigate the reliability and accuracy of serum lipid profile in assessing the prognosis/neurological worsening in patients with ischemic and hemorrhagic cerebrovascular stroke. The subjects in the present study comprised of 101 healthy controls and 150 cerebrovascular stroke patients (including 90 with ischemic stroke and 60 with intracerebral hemorrhagic stroke). In both the groups fasting lipid profile was determined within 72 h of the stroke. A statistically significant association was observed (p < 0.001) between the parameters of lipid profile of cases and healthy controls, and also with the prognosis of the stroke. 相似文献
44.
Bharosay A Saxena K Varma M Bharosay VV Pandey A 《Indian journal of clinical biochemistry : IJCB》2011,26(3):279-282
Stroke being the third leading cause of death and foremost cause of disability, if potential diagnostic utility of blood borne
protein biomarkers in predicting acute stroke is established, it would be a substantial adjunct to computerized tomography
and magnetic resonance imaging which have their own limitations. This study was done to correlate serum Interleukin 6, high
sensitivity C reactive protein at the time of admission with neurological worsening assessed by NIHSS at the time of admission
and 7 days after admission. 46 Patients admitted in neurology department SAIMS, Indore with first ever ischemic stroke within
72 h of onset were included in the study. All patients with history of stroke of more than 72 h onset, Infection & peripartum
stroke were excluded from the study. Disability scoring was done by NIHSS and their serum samples assayed for hsCRP, IL6 by
commercially available quantitative sandwich enzyme-linked immunoadsorbent assay kits. Serum samples of 50 control cases which
included healthy volunteers and staff from SAIMS were also analyzed for hsCRP, IL6 for comparative study. A significant correlation
was observed between NIHSS scoring and serum hsCRP and IL6 at the time of admission. Patients with initial high serum IL6
and hsCRP also showed significant clinical deterioration as assessed by NIHSS scoring 7 days after admission. Elevated hsCRP
and IL6 within 72 h of admission strongly correlated with functional disability in study population in India and may serve
as useful adjunct to CT Scan in emergency setting. 相似文献
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Mukherjee Manjari Rajashree A. Mokal Anagha A. Malur Chandra S Choksi Meena P. Desai 《Indian journal of clinical biochemistry : IJCB》1992,7(1):41-43
Urinary iodine was estimated chemically by the kinetic method, after mineralisation of the organic iodide by alkaline ashing. The experimental conditions were optimised. The methodological modifications of an existing technique are highlighted. Urinary iodine levels were determined in 349 school children of Bombay, of whom 163 had Grade IA/IB/II goitre and the remaining 186 did not have goitre. Urinary iodine concentration (Mean±SEM) of the control (n=186) and the goitre (n=163) groups were 76.47±4.97 and 71.09±6.23 μg/g creatinine respectively. The difference in the means was statistically not significant. Urinary iodine exhibited a log-normal distribution. It is concluded that the presence of goitre in the clinically euthyroid group of children was not caused by iodine deficiency. 相似文献
47.
Kiran Saxena N. B. Vasavada Ravi Saxena 《Indian journal of clinical biochemistry : IJCB》1991,6(2):135-141
The glycosylated haemoglobin was measured in two different categories of diabetic subjects. In poorly controlled subjects
of group II, a significant alteration in serum proteins was observed. Total protein along with albumin concentrations were
decreased and α2 globulin fraction was increased. Insulin therapy resulted in normalisation of blood glucose and gradual decrease in glycosylated
haemoglobin in the therapy period of eight weeks. This also resulted in a rise of total protein and albumin concentrations
with a decrease in α2 fraction. The present study indicates that prolonged therapy of insulin is needed to correct the serum protein abnormalities
in diabetics. 相似文献
48.
Meena Verma Sanjeev Narang Ashish Moonat Akshra Verma 《Indian journal of clinical biochemistry : IJCB》2004,19(1):129-131
Tuberculosis has, in a short span of time, become a major health problem in the third world or developing countries like India.
In view of this, a retrospective study was conducted to study Adenosine deaminase activity in serum and pleural fluid in patients
affected with Pulmonary Tuberculosis and other common non-tubercular chronic respiratory diseases. The study was carried out
on 100 patients suffering from various pulmonary disorders, between January 2002 and August 2002. Thirty-five normal healthy
individuals were included as control subjects. ADA estimation was done by sensitive colorimetric method. The study revealed
that the serum ADA activity was higher in patients of tuberculous pulmonary and pleural diseases and non-tuberculous pulmonary
diseases than in control subjects. The mean serum ADA activity in the patients’ group was 35.5±6.93 u/l as compared to 16.20±2.85
u/l in control group, showing a highly significant (P≪0.001) difference. ADA activity was highest in tuberculous pleuropulmonary
diseases. The pleural fluid ADA activity was higher in pyogenic pleural effusion than in tuberculous pleural effusion. 相似文献
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