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Non enzymatic glycosylation of IgG and their urinary excretion in patients with diabetic nephropathy
Diabetic nephropathy is a major cause of end stage renal disease. Increased excretion of albumin has widely been recognized
as an early manifestation of diabetic nephropathy particularly in subjects with diabetes mellitus. However, certain other
proteins besides albumin may be excreted in high amount during early phase of diabetic nephropathy. The serum and urinary
IgG, Glycosylated hemoglobin, fructosamine and glycosylated IgG were evaluated in the present study. Thirty-two patients of
Type 2 Diabetes without any complications, thirty-one patients of Type 2 Diabetes with nephropathy, twenty-six patients of
non-diabetic nephropathy and forty normal healthy individuals were enrolled in this study. Subjects were grouped based on
their serum creatinine level. Serum IgG, glycosylation of IgG and urinary IgG excretion were increased significantly in diabetic
patients compared to healthy controls, which were further increased significantly in chronic renal failure patients with respect
to the clinical stage of nephropathy. A positive correlation was observed between glycosylation of IgG and IgG excretion (R2=0.5995, 0.7114 respectively) in diabetic patients without any complications and diabetic nephropathy patients only, suggesting
a significant role of IgG glycosylation in the vascular clearances of IgG during diabetic nephropathy. 相似文献
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Biomimetic designs inspired by seashells 总被引:1,自引:0,他引:1
Kiran Akella 《Resonance》2012,17(6):573-591
This article explains some interesting aspects of the mechanical behaviour of seashells. Their unique brick-mortar architecture makes them tougher and stronger than their constituents. Pearly layers in seashells, also known as nacreous layers, have an order of magnitude higher toughness than most ceramics. Replication of these features of seashells in synthetic ceramics can have immediate practical applications; for example, design of lightweight, efficient and cost-effective armour. 相似文献
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Anuradha Bharosay Vivek Vikram Bharosay Meena Varma Kiran Saxena Ajoy Sodani Ravi Saxena 《Indian journal of clinical biochemistry : IJCB》2012,27(2):186-190
Stroke is the third major cause of death and foremost cause of disability worldwide. Cerebrovascular stroke remains largely a clinical diagnosis. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of neurobiochemical marker of brain damage (neuron-specific enolase [NSE]) with respect to degree of disability at the time of admission and neurological worsening in acute ischemic stroke patients. We investigated 150 patients with cerebrovascular stroke who were admitted within 72 h of onset of stroke in the Department of Neurology at SAIMS. Venous blood samples were taken after admission and NSE was analyzed by solid enzyme linked immunosorbent assay using Analyzer and microplate reader from Biored: Code 680. In all patients, the neurological status was evaluated by a standardized neurological examination and the National Institutes of Health Stroke Scale on admission and on day 7. Serum NSE concentration was found to significantly correlate with both degree of disability and neurological worsening in acute ischemic stroke cases in the present study. The maximum serum NSE level within 72 h of admission was significantly higher in patients with greater degree of disability at the time of admission. Serum NSE levels were also found to be significantly elevated in patients with bad neurological outcome. Our study showed that serum NSE has high predictive value for determining severity and early neurobehavioral outcome after acute stroke. 相似文献
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Lin TANG Wei-jun LUO Zhen-li HE Hanumanth Kumar GURAJALA Yasir HAMID Kiran Yasmin KHAN Xiao-e YANG 《Journal of Zhejiang University. Science. B》2018,(2)
目的:筛选镉-硝酸盐共低积累空心菜基因型,并研究降低空心菜重金属含量,提高营养品质的农艺措施。创新点:首次筛选得到镉-硝酸盐共低积累空心菜基因型,并研究空心菜可食部污染物、矿质元素和营养指标之间的相关性,提出进一步降低空心菜可食部镉和硝酸盐含量的农艺措施。方法:共38个空心菜基因型收集于世界各地,种植在连作了7年的中度镉-硝酸盐复合污染土壤上(Cd1.10 mg/kg,NO_3~-235.2 mg/kg),4周后收获。用HNO_3-HClO_4(体积比5:1)消煮,电感耦合等离子体质谱仪(ICP-MS)测定各种金属元素,水杨酸-硫酸比色法测定硝酸盐含量,钒钼黄比色法测定磷含量,2,6-二氯靛酚滴定法测定维生素C含量,乙醇-丙酮(体积比2:1)比色法测定叶绿素含量。结论:本试验筛选得到镉-硝酸盐共低积累空心菜基因型4个(Cd0.71 mg/kg DW,NO_3~-3100 mg/kgFW),分别是JXDY、GZQL、XGDB和B888,可以在中轻度镉-硝酸盐复合污染土壤上安全生产。空心菜地上部镉与铅、锌含量呈正相关,而这3种元素均与磷量呈负相关。这些结果表明镉、铅和锌通过相同的途径被空心菜吸收,可以同时被治理。增加磷肥供应率可以抑制复合污染土壤中的镉和硝酸盐向空心菜可食部的转移。 相似文献
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