Temporal generalization and peak shift in humans

Three experiments investigated temporal generalization in humans. In Experiment 1, a peak shift effect was produced when participants were given intradimensional discrimination training. In Experiment 2, after training with a standard S1 and generalization testing with an asymmetrical series of durations, generalization gradients moved toward the prevailing adaptation level. In Experiment 3, generalization gradients showed a central tendency shift and moved away from the S1 and toward the mean of the test series (of 11 stimulus durations) after participants received training with S1 and S2 durations that in one condition were the 2nd and 4th and in another condition were the 4th and 2nd stimuli in the series, respectively. The results were inconsistent with an absolute account of peak shift but were consistent with an adaptation level account of peak shift.     

Executive impairment determines ADHD medication response: implications for academic achievement

Methylphenidate (MPH) often ameliorates attention-deficit/hyperactivity disorder (ADHD) behavioral dysfunction according to indirect informant reports and rating scales. The standard of care behavioral MPH titration approach seldom includes direct neuropsychological or academic assessment data to determine treatment efficacy. Documenting "cool" executive-working memory (EWM) and "hot" self-regulation (SR) neuropsychological impairments could aid in differential diagnosis of ADHD subtypes and determining cognitive and academic MPH response. In this study, children aged 6 to 16 with ADHD inattentive type (IT; n = 19) and combined type (n = 33)/hyperactive-impulsive type (n = 4) (CT) participated in double-blind placebo-controlled MPH trials with baseline and randomized placebo, low MPH dose, and high MPH dose conditions. EWM/ SR measures and behavior ratings/classroom observations were rank ordered separately across conditions, with nonparametric randomization tests conducted to determine individual MPH response. Participants were subsequently grouped according to their level of cool EWM and hot SR circuit dysfunction. Robust cognitive and behavioral MPH response was achieved for children with significant baseline EWM/SR impairment, yet response was poor for those with adequate EWM/ SR baseline performance. Even for strong MPH responders, the best dose for neuropsychological functioning was typically lower than the best dose for behavior. Findings offer one possible explanation for why long-term academic MPH treatment gains in ADHD have not been realized. Implications for academic achievement and medication titration practices for children with behaviorally diagnosed ADHD will be discussed.     

凯文·加内特呼啸而过

曾经,他是一头无法驯服的“狼王”;曾经,他的暴扣、大吼、怒目圆睁震颤整个联盟;曾经,他的小动作、垃圾话无人能敌。如今,他是一个依然矫健的“绿巨人”;如今,他的血性、挑衅、争辩还有胡须依然存在;如今,凯文·加内特依然可以从你身边呼啸而过。     

Cell biology apps for apple devices

Apps for touch-pad devices hold promise for guiding and supporting learning. Students may use them in the classroom or on their own for didactic instruction, just-in-time learning, or review. Since Apple touch-pad devices (i.e., iPad and iPhone) have a substantial share of the touch-pad device market (Campbell, 2012), this Feature will explore cell biology apps available from the App Store. My review includes iPad and iPhone apps available in June 2012, but does not include courses, lectures, podcasts, audiobooks, texts, or other books. I rated each app on a five-point scale (1 star = lowest; 5 stars = highest) for educational and production values; I also provide an overall score.