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排序方式: 共有545条查询结果,搜索用时 15 毫秒
41.
Ipsita Choudhury R. Jothimalar Arun Kumar Patra 《Indian journal of clinical biochemistry : IJCB》2012,27(3):265-269
Hypertension, a well known risk factor for various cardiovascular, peripheral vascular and renal events is an important public health challenge. Renin angiotensin system (RAS) being the most vital pathogenic mechanism of hypertension is mediated by a key component; the angiotensin converting enzyme (ACE). The present study was aimed to know the relationship of ACE gene polymorphism and the possible risk of development of hypertension in south Indian population. The study included 101 clinically diagnosed hypertensive patients without any associated disease condition and 81 age and sex matched apparently healthy controls. Genotyping was performed using a polymerase chain reaction, (PCR) amplification of the intron 16 fragment harboring the 287 bp Alu repeat sequence. Three possible genotypes D/D, I/I homozygous and I/D heterozygous were analyzed where the D/D genotypes corresponds to higher ACE levels (D-Deletion, I-Insertion). The PCR products were separated on 2 % agarose gel. Statistical analysis was performed using SPSS.15 software program. We found a significance in frequency of D/D genotype in the hypertensive patients compared to the control group (p = 0.0005, odd’s ratio = 4.157). This suggested that ACE (D/D) genotypes are more prone for the development of hypertension. This is relatively a pilot study; but nevertheless may assist in identifying the pathophysiological cause of hypertension. 相似文献
42.
Tapas Kumar Ghosh K.C. Panda 《Library Collections, Acquisitions, and Technical Services》2010,34(2-3):45-50
The vital task of the libraries attached to the educational institutions of higher learning is the collection development of information resources as per the requirements of the users. The Central Library of IITs have long been recognized their responsibility to support the study and research of their parent institutions with the rich collection development of information resources both in print as well as electronic format to cater the needs of the academic communities as per the multi-disciplinary and diverse academic program of the respective institutions where greater emphasis on collection of serials, the essential and integral component of updated scholarly communication. The study provides a vivid picture about the current status of serials collection in the libraries attached to the Premier Institutions of India in the field of science and technology to boost up the academic performances. 相似文献
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Abstract One of the major impediments for diversification of groundnut (Arachis Hypogaea L.) as food crop is aflatoxin contamination. The study was conducted with an objective to assess the adoption gaps in aflatoxin management practices of groundnut (AMPG) and the farmer's characteristics influencing these gaps. The study used an expost-facto research design and multi-stage random sampling. The data were collected from 180 respondents through interview schedule. For measuring adoption gap, knowledge of AMPG and perception of groundnut quality suitable scales were developed. The data were subjected to multiple regression analysis to know the characteristics, which influenced the adoption gaps in AMPG. The majority of farmers were in high adoption gap category, as most of the farmers had not adopted the harvest and post-harvest management practices. Farmers' characteristics such as knowledge, market orientation and innovativeness influenced the adoption gap significantly. These three variables put together explained 58% of variation in adoption gap. Based on the results, it is suggested to formulate strategies to increase the knowledge of farmers through various extension approaches. If the knowledge on AMPG is improved the adoption gaps can be reduced. The maiden research effort, shed light on the socio-economic dimensions of aflatoxin contamination and constraints for aflatoxin management at farmers' level. The study has significance for the policy makers, extension departments and groundnut farmers for production of quality groundnut. 相似文献
45.
Surabhi Verma Som Sekhar Bhattacharyya Saurav Kumar 《Information processing & management》2018,54(5):791-806
Research on the adoption of systems for big data analytics has drawn enormous attention in Information Systems research. This study extends big data analytics adoption research by examining the effects of system characteristics on the attitude of managers towards the usage of big data analytics systems. A research model has been proposed in this study based on an extensive review of literature pertaining to the Technology Acceptance Model, with further validation by a survey of 150 big data analytics users. Results of this survey confirm that characteristics of the big data analytics system have significant direct and indirect effects on belief in the benefits of big data analytics systems and perceived usefulness, attitude and adoption. Moreover, there are mediation effects that exist among the system characteristics, benefits of big data analytics systems, perceived usefulness and the attitude towards using big data analytics system. This study expands the existing body of knowledge on the adoption of big data analytics systems, and benefits big data analytics providers and vendors while helping in the formulation of their business models. 相似文献
46.
Yogesh M. Patel Sanidhya Jain Abhishek Kumar Singh Kedar Khare Sarita Ahlawat Supreet Singh Bahga 《Biomicrofluidics》2020,14(6)
We present design, characterization, and testing of an inexpensive, sheath-flow based microfluidic device for three-dimensional (3D) hydrodynamic focusing of cells in imaging flow cytometry. In contrast to other 3D sheathing devices, our device hydrodynamically focuses the cells in a single-file near the bottom wall of the microchannel that allows imaging cells with high magnification and low working distance objectives, without the need for small device dimensions. The relatively large dimensions of the microchannels enable easy fabrication using less-precise fabrication techniques, and the simplicity of the device design avoids the need for tedious alignment of various layers. We have characterized the performance of the device with 3D numerical simulations and validated these simulations with experiments of hydrodynamic focusing of a fluorescently dyed sample fluid. The simulations show that the width and the height of the 3D focused sample stream can be controlled independently by varying the heights of main and side channels of the device, and the flow rates of sample and sheath fluids. Based on simulations, we also provide useful guidelines for choosing the device dimensions and flow rates for focusing cells of a particular size. Thereafter, we demonstrate the applicability of our device for imaging a large number of RBCs using brightfield microscopy. We also discuss the choice of the region of interest and camera frame rate so as to image each cell individually in our device. The design of our microfluidic device makes it equally applicable for imaging cells of different sizes using various other imaging techniques such as phase-contrast and fluorescence microscopy. 相似文献
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Solitons emerge as non-perturbative solutions of non-linear wave equations in classical and quantum theories. These are non-dispersive
and localised packets of energy — remarkable properties for solutions of non-linear differential equations. In the presence
of such objects, the solutions of Dirac equation lead to the curious phenomenon of ‘fractional fermion number’. Under normal
conditions the fermion number takes strictly integral values. In this article, we describe this accidental discovery and its
manifestation in polyacetylene chains, which has led to the development of organic conductors.
(left) Kumar Rao is a Postdoctoral Fellow at PRL, Ahmedabad. He is interested in particle physics phenomenology as probed
in particle colliders and formal aspects of quantum field theory.
(right) Narendra Sahu is currently a postdoctoral fellow at Lancaster University, UK. His main research area includes Cosmology
and Astroparticle physics. Currently he is working on dark matter and matter anti-matter asymmetry of the universe.
(center) P K Panigrahi’s research interests are in the area of quantum computation, solitons in Bose Einstein condensates
& nonlinear optical media. He is also deeply interested in science education and derives pleasure from long weekend walks. 相似文献
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Shubham Goel Ravinder Kumar Munish Kumar Vikram Chopra 《Information processing & management》2019,56(3):1053-1066
In the whole world, the internet is exercised by millions of people every day for information retrieval. Even for a small to smaller task like fixing a fan, to cook food or even to iron clothes persons opt to search the web. To fulfill the information needs of people, there are billions of web pages, each having a different degree of relevance to the topic of interest (TOI), scattered throughout the web but this huge size makes manual information retrieval impossible. The page ranking algorithm is an integral part of search engines as it arranges web pages associated with a queried TOI in order of their relevance level. It, therefore, plays an important role in regulating the search quality and user experience for information retrieval. PageRank, HITS, and SALSA are well-known page ranking algorithm based on link structure analysis of a seed set, but ranking given by them has not yet been efficient. In this paper, we propose a variant of SALSA to give sNorm(p) for the efficient ranking of web pages. Our approach relies on a p-Norm from Vector Norm family in a novel way for the ranking of web pages as Vector Norms can reduce the impact of low authority weight in hub weight calculation in an efficient way. Our study, then compares the rankings given by PageRank, HITS, SALSA, and sNorm(p) to the same pages in the same query. The effectiveness of the proposed approach over state of the art methods has been shown using performance measurement technique, Mean Reciprocal Rank (MRR), Precision, Mean Average Precision (MAP), Discounted Cumulative Gain (DCG) and Normalized DCG (NDCG). The experimentation is performed on a dataset acquired after pre-processing of the results collected from initial few pages retrieved for a query by the Google search engine. Based on the type and amount of in-hand domain expertise 30 queries are designed. The extensive evaluation and result analysis are performed using MRR, [email protected], MAP, DCG, and NDCG as the performance measuring statistical metrics. Furthermore, results are statistically verified using a significance test. Findings show that our approach outperforms state of the art methods by attaining 0.8666 as MRR value, 0.7957 as MAP value. Thus contributing to the improvement in the ranking of web pages more efficiently as compared to its counterparts. 相似文献