Is short-term therapy really sufficient to eradicate Helicobacter pylori infection?

Objective:The aim of our study was to perform a systematic review and meta-analysis of the efficacy of short-term protocols for Helicobacter pylori eradication and to review the safety and adverse profiles of these eradication protocols.Methods:Literatures were located through electronic searches by PubMed,Medline,ISI Web of Knowledge,and Cochrane Library using the relevant terms.Abstracts of important meetings were searched manually in some journal supplements.Additional bibliographies were identified from the reference lists of identified studies.Three independent reviewers systemically identified randomized controlled trials(RCTs) comparing short-duration protocols vs.7-d proton pump inhibitor(PPI)-based triple protocols,as well as studies reporting eradication rates of short-duration protocols for H.pylori.Summary effect size was calculated as relative risk(RR) and 95% confidence intervals(CI) using Review Manager 4.2,and P0.05 was defined as statistically significant in all analyses.Results:Among 90 abstracts retrieved,15 studies were analyzed,including a total of 30 treatment regimens with 1856 subjects.Mean intention-to-treat(ITT) cure rates of 63.2% and 81.3% were achieved with short-term protocols and 7-d PPI-containing protocols,respectively.Per-protocol(PP)-based overall cure rates were 66.6% and 86.1%,respectively.Short-term therapy was inferior to 7-d triple regimen(P0.00001).After sub-analysis,however,comparing the effects of ≥3-d protocols and 7-d triple protocols,the cumulative ITT RR was 0.95(P=0.26),and PP RR was 0.95(P=0.10),without significant heterogeneity.Moreover,slightly fewer adverse-effects were found in short-term protocols.Conclusions:Although more economical,short-duration protocols are inferior to 7-d PPI-based triple protocols with regarding to eradication rate of H.pylori.Protocols of more than 3 d,however,may be equivalent to 7-d protocols.     

An intelligent electronic capsule system for automated detection of gastrointestinal bleeding

In clinical practice, examination of the hemorrhagic spot (HS) remains difficult. In this paper, we describe a remote controlled capsule (RCC) micro-system with an automated, color-based sensor to identify and localize the HS of the gastrointestinal (GI) tract. In vitro testing of the detecting sensor demonstrated that it was capable of discriminating mimetic intestinal fluid (MIF) with and without the hemoglobin (Hb) when the concentration of Hb in MIF was above 0.05 g/ml. Therefore, this RCC system is able to detect the relatively accurate location of the HS in the GI tract.     

基于EDA仿真软件的多资源调度算法

为提高电子设计自动化（electronic design automation,EDA）并行仿真任务的资源利用率并保证公平性,在占优资源公平分配机制（dominant resource fariness,DRF）的基础上,提出考虑license的占优资源公平分配（dominant resource fairness allocation algorithm considering license,LDRF）算法。一方面考虑多类型资源的公平调度问题,满足EDA任务对资源种类多样性的需求;另一方面考虑对EDA工具的license资源调度,避免任务占有硬件资源但是没有获得license授权不能运行,导致资源利用率下降。实验仿真结果表明,在license有限的条件下,LDRF的平均CPU资源利用率比DRF算法提高60%,平均内存资源利用率比DRF算法提高34%。     

化学学科能力的基本理论问题研究

我国《化学教学大纲》、《化学课程标准》、高考化学《考试大纲(大纲版)》、《考试大纲(课标版)》分别提出了不同内涵的化学学科能力要求,其原因在于,化学学科能力理论的建构缺乏明确的理论基础。为此,我们构建了智力—知识—技能—科学方法能力理论,提出了化学学科的核心能力——观察与实验能力、化学学习能力、化学思维能力、科学探究能力、实践与创新能力,并界定了其能力结构要素。这一能力观对于改变课程改革中能力内涵模糊、能力要求弱化的现状具有非常重要的现实意义。     

开明书店的市场开拓策略述论（1926—1937）

民国时期民营出版业异常繁荣。出版机构林立,彼此之间竞争异常激烈。开明书店创办于1926年,是民国出版市场的＂后起之秀＂,创设伊始即注重编辑高质量的图书,团结作者和读者,通过大量广告、廉价促销、读书营销等方式,并坚持文化出版的理念,最终在出版市场站稳脚跟,跻身于民国时期大出版机构的行列。     

高校礼仪课程教学改革初探

在21世纪人才竞争的时代,高校礼仪教育是大学生素质教育重要的组成部分,对建设校园文化,创建和谐社会起着重要的作用。但在高校中礼仪课程教学还存在着教学理念与教学方法等诸多不足之处。针对礼仪课程的性质和特点,对高校开展礼仪课程教学提出了从学生主观学习意识和教师教学法改革及考核方式上做了一些有效的探索。     

《数据结构》教学改革的探索与实践

从课堂教学内容、课件制作、课堂教学方法、实验教学、课程设置等方面对《数据结构》课程的教学进行了探索与实践。     

基于工作过程的国际贸易实务专业课程开发实践研究

本文针对我国高职院校在课程设置开发方面存在的问题,运用基于工作过程的课程开发模式,以国际贸易实务专业课程开发过程为例、依循“工作岗位-行动领域-学习领域-情境设计”开发机理,系统地阐明了课程开发设置的全过程及其效果。实现了课程设置与工作岗位要求有机吻合,从而使课程开发更加贴近工作岗位实际要求。     

愉快教学法在《微型计算机原理》教学中的应用

愉快教学法在大学本科教学中的应用,能使师生在轻松愉快的环境中完成教学任务。文章详细介绍了愉快教学法在大学本科教学中的应用方法,以营造轻松愉快的课堂气氛、实施一视同仁的民主教育、进行有趣的情景教学和将多媒体引入课堂教学为主要手段,结合实际教学经验进行实施,积极引导学生学习的能动性,大大提高了教学效果。     

从哈贝马斯的交往行为理论再思素质教育的内涵

当前,国内关于素质教育的讨论虽然沸沸扬扬,但却缺乏统一的内涵界定.本文依据哈贝马斯的交往行为理论,指出素质教育本质上是一种交往活动.针对有效交往的真实性、正当性和真诚性的要求,素质教育应该以能力教育为基础,以道德教育为灵魂,以主体间性为主要特征.