Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance

Journal of Zhejiang University-SCIENCE B - Microglia are important cells involved in the regulation of neuropathic pain (NPP) and morphine tolerance. Information on their plasticity and polarity...     

发挥高校内部审计作用刍议

高校的经济业务活动涉及到各个方面和各个部门,规范财务管理,保障其收入和支出的合法性、合理性和高效性,加强内部审计尤其重要.文章就高校内部审计的作用、现状,以及如何发挥高校内部审计的作用进行探讨.     

海南远程教师培训的实践分析与改进策略

教师培训是当前推进基础教育课程改革的一项紧迫任务。顺利实施新课程远程教师培训应该从培训本身的资源建设和实施培训的条件两个方面考虑。本文依托海南远程教师培训个案,从实践的角度分析新课程远程教师培训中存在的问题,并从资源建设和实施条件两个方面提出了改进策略。     

高师进行普通话教学探析

高师普通话教学课时少，任务重，因此如何在有限的时间内提高学生普通话水平就显得尤为重要。文章根据个人普通话教学和测试的体会，就高师普通话教学内容和方式进行探索。     

试析"心理疗法"对实现压力最优化的影响

日常生活中,组织中的个体难免会面对来自组织内外部的压力.压力不一定是件坏事,但如何使其保持一定水平,并将其化解为激发人的动力是值得探讨的课题.人的行为是受其心理活动支配的,文章通过分析心理因素,阐释了个体对压力反映强弱的缘由,提出用"心理疗法"来实现压力最优化,从而提高工作绩效.     

Gelation Mechanism of Erythromycin Ethylsuccinate During Crystallization

In this paper, the gelation mechanism of erythromycin ethylsuccinate(EES) during crystallization is investigated for the first time. The generated semisolid gel-like phase exhibited a 3D fibrillar network morphology and the typical rheological properties of gels. The fibers inside the gel-like phase were confirmed to be new types of EES solvates using powder X-ray diffraction, thermogravimetric analysis/differential scanning calorimetry, and gas chromatography. The gelation and crystallization regions in EES-1-propanol solid–liquid phase diagram were determined. Analyses of solvent parameters showed that moderate solvent polarity may promote EES gelation. Fourier transform infrared spectra, nuclear magnetic resonance spectra, and scanning electron microscopy analyses indicated that through intermolecular hydrogen bonds, EES and solvent molecules assembled into fibers via crystallographic mismatch branching growth. The fibers intertwined into a 3D network microstructure and formed a gel-like phase, completely immobilizing the solution.     

构建高水平、有活力的教师教育体系的思考

纵观国际师范教育发展趋势，师范教育体系将最终逐步从一元封闭型向多元开放型转变。通过对师范教育面临的挑战，以及社会经济，教育的发展形势分析，提出高水平，有活力的教师教育体系的构建思路。     

谈谈石灰岩荒山的景观生态建设问题

本文以华北石灰岩荒山为例,介绍了景观生态建设的调查方法和景观生态特征,并就石灰岩荒山的景观生态建设问题提出了几点看法。     

Science Letters： In-situ synthesis and luminescence properties of titanium oxide gels containing 1,10-phenanthroline europium（Ⅲ） complex

It is difficult to directly dope europium complexes in gel because the excessive water or high acidic condition may lead to their decomposition. We prepared a novel homogeneous TiO2 gel containing Eu-phen complexes by using an in-situ synthesis method. The formation of Eu-phen complexes in sol-gel derived TiO2 was confirmed by luminescence excitation spectra. The effects of temperature and aging time on in-situ synthesis are discussed. The luminescence spectra of gel containing europium complexes were also compared with the pure Eu-phen complexes.     

A theory of instruction for introductory programming skills

ABSTRACT

Background and Context: Current introductory instruction fails to identify, structure, and sequence the many skills involved in programming.

Objective: We proposed a theory which identifies four distinct skills that novices learn incrementally. These skills are tracing, writing syntax, comprehending templates (reusable abstractions of programming knowledge), and writing code with templates. We theorized that explicit instruction of these skills decreases cognitive demand.

Method: We conducted an exploratory mixed-methods study and compared students’ exercise completion rates, error rates, ability to explain code, and engagement when learning to program. We compared material that reflects this theory to more traditional material that does not distinguish between skills.

Findings: Teaching skills incrementally resulted in improved completion rate on practice exercises, and decreased error rate and improved understanding of the post-test.

Implications: By structuring programming skills such that they can be taught explicitly and incrementally, we can inform instructional design and improve future research on understanding how novice programmers develop understanding.