Are we using Thyroid Function Tests Appropriately?

Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples (87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests. 77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7% in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction and order the appropriate test in a rational and cost effective manner.     

Dynamics of the basketball shot with application to the free throw

A completely general three-dimensional dynamic model is presented for the motion of basketball shots that may contact the rim, the backboard, the bridge between the rim and board, and possibly the board and the bridge simultaneously. Non-linear ordinary differential equations with six degrees of freedom describe the ball angular velocity and ball centre position. The model includes radial ball compliance and damping and contains five sub-models: purely gravitational flight, and ball-rim, ball-bridge, ball-board, and ball-bridge-board contact. Each contact sub-model has both slipping and non-slipping motions. Switching between the sub-models depends on the reaction force at, and velocity of, the contact point. Although the model can be used to study shots from any point on the court, we here use it to study the sets of free throw release angle, velocity, angular velocity, and lateral deviation angle that result in success (capture), as well as underhand free throws and those using an under-inflated ball. Free throw shots with larger backspin, lower inflation pressures, and underhand release conditions are shown to result in larger capture percentages.     

The development of children at familial risk for dyslexia: Birth to early school age

Children at risk for familial dyslexia (n = 107) and their controls (n = 93) have been followed from birth to school entry in the Jyvaskyla Longitudinal study of Dyslexia (JLD) on developmental factors linked to reading and dyslexia. At the point of school entry, the majority of the at-risk children displayed decoding ability that fell at least 1 SD below the mean of the control group. Measures of speech processing were the earliest indices to show both group differences in infancy and also significant predictive associations with reading acquisition. A number of measures of language, including phonological and morphological skill collected repeatedly from age three, revealed group differences and predictive correlations. Both the group differences and the predictive associations to later language and reading ability strengthened as a function of increasing age. The predictions, however, tend to be stronger and the spectrum of significant correlations wider in the at-risk group. These results are crucial to early identification and intervention of dyslexia in at-risk children.     

Comparative orotomy of the Archean Superior and Phanerozoic Altaid orogenic systems

We compare and contrast the materials and mechanisms of continental crustal growth in the largest preserved regions of Phanerozoic and Archean juvenile additions to the crust,to test for similarities or differences in the formation of continents through time.We accomplish this through a comparison of map patterns,lithological contents,and structural and metamorphic evolution of the Phanerozoic Altaid orogenic system of Asia,with the Archean Superior Province of the North American Craton,using a ...     

Learning surgically oriented anatomy in a student-run extracurricular club: an education through recreation initiative

Didactic and laboratory anatomical education have seen significant reductions in the medical school curriculum due, in part, to the current shift from basic science to more clinically based teaching in North American medical schools. In order to increase medical student exposure to anatomy, with clinical applicability, a student-run initiative called surgically oriented anatomy prosectors (SOAP) club was created within the extracurricular program at the Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada. SOAP invites surgeons and residents from various surgical specialties to demonstrate, on a cadaver, a surgical procedure of their choosing. During the demonstration, the anatomy, as it relates to the surgical procedure, is discussed. The students then break into smaller groups to examine the relevant anatomy on the cadavers, during which time the discussion is broadened. The group continues the conversation in a social environment with refreshments. SOAP is one of the most popular extracurricular clubs with 65% of first and second year medical students registered as members. The high demand for SOAP, along with the positive participant feedback, may be due to its utilization of the principle of education through recreation, which seeks to provide opportunities for learning seamlessly throughout all facets of life. It also demonstrates the desire, amongst certain medical students, to learn applied anatomy, particularly within a surgical context.     

Changes in the prevalence of child sexual abuse, its risk factors, and their associations as a function of age cohort in a Finnish population sample

Objective

We examined (1) the prevalence of childhood sexual abuse (CSA) experiences as a function of cohort and gender, (2) the prevalence of factors associated with CSA as a function of cohort and whether the association of these factors with CSA remained the same irrespective of cohort, and (3) whether any cohort differences could be explainable by cohort differences in reporting bias.

Method

We used the responses of 4,561 men (M = 29, SD = 7 years) and 8,361 female (M = 29, SD = 7 years) Finnish participants who responded to the Childhood Trauma Questionnaire-Short Form as well as questions regarding family structure.

Results

The prevalence of CSA experiences varied between 0.7-4.6% for men and 1.8-7.5% for women depending on the item. Younger cohorts reported less CSA as well as less of the risk factors (physical neglect and abuse, emotional neglect and abuse, parental substances abuse, not growing up with both biological parents) that were positively associated with the likelihood of CSA. The effects of these risk factors did not vary as a function of the cohort. Also, the declining trend was not explainable by social desirability being higher in the younger cohorts.

Conclusions

The results suggest that there is a real decline in the prevalence of CSA and it is associated with a simultaneous decline in factors associated with CSA.     

The interaction of functional and dysfunctional emotions during balance beam performance

The interaction between functional and dysfunctional emotions, as one of the major tenets of the individual zones of optimal functioning (IZOF) model (Hanin, 2000), was studied in a sport specific setting. Fourteen female gymnasts performed three attempts of a compulsory balance beam routine at three different heights. Heart rate and self-report of functional and dysfunctional emotions were measured during each routine. These data revealed the effectiveness of inducting emotions by manipulating height. Also, performance decreased on the most challenging condition, (i.e., the first attempt on the highest height). Moderated hierarchical regression analysis revealed a significant interaction between functional and dysfunctional emotions only when the dysfunctional emotion level was low.     

QTL analysis for some quantitative traits in bread wheat

Quantitative trait loci (QTL) analysis was conducted in bread wheat for 14 important traits utilizing data from four different mapping populations involving different approaches of QTL analysis. Analysis for grain protein content (GPC) sug- gested that the major part of genetic variation for this trait is due to environmental interactions. In contrast, pre-harvest sprouting tolerance (PHST) was controlled mainly by main effect QTL (M-QTL) with very little genetic variation due to environmental interactions; a major QTL for PHST was detected on chromosome arm 3AL. For grain weight, one QTL each was detected on chromosome arms 1AS, 2BS and 7AS. QTL for 4 growth related traits taken together detected by different methods ranged from 37 to 40; nine QTL that were detected by single-locus as well as two-locus analyses were all M-QTL. Similarly, single-locus and two-locus QTL analyses for seven yield and yield contributing traits in two populations respectively allowed detection of 25 and 50 QTL by composite interval mapping (CIM), 16 and 25 QTL by multiple-trait composite interval mapping (MCIM) and 38 and 37 QTL by two-locus analyses. These studies should prove useful in QTL cloning and wheat improvement through marker aided selection.     

外尔斯特拉斯逼近定理的概率证明

在外尔斯特拉斯逼近定理的各种证明中,伯恩斯坦的证明谅必最普通。它特别有感染力,因为它是构造证明。如果f是区间[0,1]上的连续实值函数,伯恩斯坦多项式序列