关联理论与汉语句末虚词的语篇功能

现代汉语句末虚词"啊/呀""吧""呢""嘛"等,一般称为"情态虚词",以别于具有较多实质语义或语法功能的"了""吗""的"等虚词.其实,前者固然表达情态,如分别表示,"关注""存疑""深究""确信"等;但此等虚词对于篇章的连接,也具有非常重要的作用.从关联理论及语篇标记的视角,参照以往研究,对该等情态虚词之语篇功能考察,可以看到:(一)"啊/呀"除了对当时的情景或对话内容表示"关注"而外,尚有特别标示"该语句乃针对当前语境而发"的功能;(二)"吧"除了标示"存疑"而外,尚有标示"该句乃针对先前所说或所发生的情景而发";(三)"呢"主要标示两种不同的、但前后呼应的语篇功能:(1)寻求与上文对比,(2)要求继续对话.这三个句末虚词,在语篇组织上,均具有增强关联性的功能.故除了当作"情态虚词"处理而外,还可以看作是"语篇标记".作为语篇标记,其强弱排序应为:呢>吧>啊/呀.此一排序,恰恰与其情态性质之强弱相反:呢<吧<啊/呀.     

让我们更多地认识城市与城市研究(二)

本文是美国圣地亚哥大学教授詹姆斯·A·克莱普2008年4月在北京城市学院的演讲,演讲共三场。为便于读者全面地理解克莱普教授的演讲内容,全部演讲内容被编译成一篇。本文是根据演讲记录稿整理后,经克莱普教授本人审定英文稿编译。     

A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2

The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus, and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed. On the other hand, several concerning SARS-CoV-2 variants, including Omicron, are required to be identified as soon as the samples are identified as ‘positive’. Unfortunately, a traditional PCR test does not allow their specific identification. Herein, for the first time, we have developed MOPCS (Methodologies of Photonic CRISPR Sensing), which combines an optical sensing technology-surface plasmon resonance (SPR) with the ‘gene scissors’ clustered regularly interspaced short palindromic repeat (CRISPR) technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants. MOPCS is a low-cost, CRISPR/Cas12a-system-empowered SPR gene-detecting platform that can analyze viral RNA, without the need for amplification, within 38 min from sample input to results output, and achieve a limit of detection of 15 fM. MOPCS achieves a highly sensitive analysis of SARS-CoV-2, and mutations appear in variants B.1.617.2 (Delta), B.1.1.529 (Omicron) and BA.1 (a subtype of Omicron). This platform was also used to analyze some recently collected patient samples from a local outbreak in China, identified by the Centers for Disease Control and Prevention. This innovative CRISPR-empowered SPR platform will further contribute to the fast, sensitive and accurate detection of target nucleic acid sequences with single-base mutations.     

研究生学历能否提升企业绩效？ ——基于上市公司高层管理者简历的大数据分析

基于上市公司高层管理者的简历数据,采用基准回归模型,实证测量了研究生学历与企业绩效的作用机制。研究发现,从整体趋势审视,企业高管团队包括董事长的学历水平与企业绩效呈明显正相关。从异质性维度审视,不同发展阶段、不同股权性质、不同规模的企业,董事长和高管团队的学历对企业绩效的影响呈现差异化。因此,高学历高管数量应与企业实况相匹配,区分并重视企业异质性对学历的影响与需求,同时应创新高校现有就业指导政策中的常规做法。     

博士生跨学科学位论文研究的现状及其影响因素 ——基于全国博士毕业生调查的分析

基于2022年的全国博士毕业生调查对我国博士生跨学科学位论文研究的基本面貌及其影响因素展开分析。研究发现：第一,整体上,跨学科选题学位论文的创新性和应用价值更高,但仅14.5%的博士生表示自己为跨学科选题,理、工、农、医博士生中学位论文选题跨学科的比例明显低于人文社科。第二,外在读博动机弱、硕博阶段就读学科不同的博士生更有可能做跨学科学位论文研究。相比单一导师指导,多学科导师联合指导下博士生做跨学科学位论文研究的概率更大,而单学科导师联合指导下的概率更小。在论文发表要求的压力下,博士生做跨学科学位论文的概率将下降。第三,理工农医博士生跨学科学位论文研究的质量保障需依赖多学科的导师联合指导。为促进我国博士生的跨学科学位论文研究,院校应积极招收具有跨学科背景及兴趣的博士生,加强多学科导师联合指导制度的建设,创设更宽松的学术评价环境。     

高校教师隐性知识转移与共享因素分析

利用对高校教师隐性知识转移的调查,分析了高校教师隐性知识转移的现状、影响因素及对绩效的影响.分析表明,个人接触是最好的隐性知识转移方式,而对人际关系忠诚、情感距离及团队的目标、氛围、领导风格是影响团队成员隐性知识共享的重要因素;在隐性知识共享对绩效的影响方面,普遍认为,隐性知识共享能够增加团队成员科研成果的数量、质量,节约科研时间、成本,同时也有利于团队成员获得更多的发展机会.     

Circulating Cell-Free DNA Level in Prediction of COVID-19 Severity and Mortality: Correlation of with Haematology and Serum Biochemical Parameters

Lymphocyte dysregulation in coronavirus disease-19 (COVID-19) is a major contributing factor linked to disease severity and mortality. Apoptosis results in the accumulation of cell-free DNA (cfDNA) in circulation. COVID-19 has a heterogeneous clinical course. The role of cfDNA levels was studied to assess the severity and outcome of COVID-19 patients and correlated with other laboratory parameters. The current case series included 100 patients with mild COVID-19 (MCOV-19) and 106 patients with severe COVID-19 (SCOV-19). Plasma cfDNA levels were quantified using SYBR green quantitative real-time PCR through amplification of the β-actin gene. CfDNA level was significantly higher in SCOV-19 at 706.7 ng/ml (522.6–1258) as compared to MCOV-19 at 219.8 ng/ml (167.7–299.6). The cfDNA levels were significantly higher in non-survivor than in survivors (p = 0.0001). CfDNA showed a significant correlation with NLR, ferritin, LDH, procalcitonin, and IL-6. The diagnostic sensitivity and specificity of cfDNA in the discrimination of SCOV-19 from MCOV-19 were 90.57% & 80%, respectively. CfDNA showed a sensitivity of 94.74% in the differentiation of non-survivors from survivors. CfDNA levels showed a significant positive correlation with other laboratory and inflammatory markers of COVID-19. CfDNA levels, NLR, and other parameters may be used to stratify and monitor COVID-19 patients and predict mortality. CfDNA may be used to predict COVID-19 severity with higher diagnostic sensitivity.     

谁改变了我们的常识?——美国教育保守主义运动与教育不平等

本文考察和分析了美国教育走向保守主义的趋势及其所引发的冲突和斗争。美国教育政策的保守趋势运动是多元的,存在着不同的取向,主要有四种力量构成新自由主义、新保守主义、威权民粹主义和正处在上升阶段的由专业人员和管理人员所构成的新中产阶级。本文侧重探讨了保守主义在改造美国教育的运动中居于领导地位的前两支力量,并认为在教育和社会政策领域,这些力量成功地构建成一个联盟,该联盟成功的重要原因在于对常识的改造,作者将之称为“保守主义的现代化”。     

合作数字参考咨询的合作模式研究

通过对合作数字参考咨询发展的研究,发现我国合作数字参考咨询存在着模式不清晰等问题,文章针对此问题阐释了合作数字参考咨询的内涵,建立了适合我国国情的三角式合作咨询模式。     

数字资源整合模式的比较研究

本文依据信息资源的存储与检索方式,将信息资源整合大体分为实体法与虚拟法这两种模式,并对这两种模式进行详细说明;然后分别描述和比较两种数字资源整合模式下的信息资源整合系统架构及功能特点,指出各自的优势和不足;最后结合两种模式的优点,提出数字资源整合的综合解决方案。