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S. P. Kulkarni C. R. Mallikarjuna D. S. Jayaprakash Murthy 《Indian journal of clinical biochemistry : IJCB》2006,21(1):185-188
Background Sialic acid (SA) is a nine carbon sugar derived from mannosamine and pyruvate. High levels of sialic acid and aspartate transaminase
(AST) levels in cerebrospinal fluid have been described in pyogenic meningitis (PM) compared to tubercular meningitis (TBM).
Objectives To evaluate the levels of CSF free SA in PM and TBM and to assess the correlation between CSF free SA and CSF glucose or total
protein levels.
Patients and Methods A total of 122 subjects were studied and divided into children and adults. Further, these have been subdivided into controls,
PM and TBM. CSF free SA was estimated by thiobarbituric acid assay of Warren and AST by Reitmann and Frankel method.
Results CSF free SA and AST levels in children and adults were significantly high in PM (p<0.001) as compared to TBM and controls.
Conclusion A very high CSF free SA and AST were found to be characteristic of PM, making them useful parameters to differentiate PM from
TBM. 相似文献
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P. Aruna Prabhavathi Tajamul Hussain G. N. Mallikarjuna Rao MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(1):94-98
The efficacy of two intragenic polymorphic markers of factor VIII gene has been examined in Andhra Pradesh population with
a view to confirm/revise the strategy for carrier detection that would be precise and economical. The haemophilia A carrier
was detected using Bcl I and Xba I polymorphic sites in intron 18 and 22 respectively. The cumulative efficiency of these
two sites for detection of carriers is 100% since all 15 families tested were informative for one of these polymorphisms,
thus confirming their usefulness for factor VIII gene mutations found in Andhra Pradesh. 相似文献
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