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161.
Serap ?uhadar Mehmet K?seo?lu Yasemin ?inpolat Güler Bu?dayc? Murat Usta Tuna Semerci 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2016,26(1):53-60
Introduction
Extremely high glucose concentrations have been shown to interfere with creatinine assays especially with Jaffe method in peritoneal dialysate. Because diabetes is the fastest growing chronic disease in the world, laboratories study with varying glucose concentrations. We investigated whether different levels of glucose spiked in serum interfere with 21 routine chemistry and thyroid assays at glucose concentrations between 17-51 mmol/L.Materials and methods
Baseline (group I) serum pool with glucose concentration of 5.55 (5.44-5.61) mmol/L was prepared from patient sera. Spiking with 20% dextrose solution, sample groups were obtained with glucose concentrations: 17.09, 34.52, and 50.95 mmol/L (group II, III, IV, respectively). Total of 21 biochemistry analytes and thyroid tests were studied on Abbott c8000 and i2000sr with commercial reagents. Bias from baseline value was checked statistically and clinically.Results
Creatinine increased significantly by 8.74%, 31.66%, 55.31% at groups II, III, IV, respectively with P values of < 0.001. At the median glucose concentration of 50.95 mmol/L, calcium, albumin, chloride and FT4 biased significantly clinically (-0.85%, 1.63%, 0.65%, 7.4% with P values 0.138, 0.214, 0.004, < 0.001, respectively). Remaining assays were free of interference.Conclusion
Among the numerous biochemical parameters studied, only a few parameters are affected by dramatically increased glucose concentration. The creatinine measurements obtained in human sera with the Jaffe alkaline method at high glucose concentrations should be interpreted with caution. Other tests that were affected with extremely high glucose concentrations were calcium, albumin, chloride and FT4, hence results should be taken into consideration in patients with poor diabetic control.Key words: assay interference, glucose interference, preanalytical phase, creatinine, Jaffe kinetic assay, thyroid function tests 相似文献162.
T. Malati G. Rajani Kumari P. V. L. N. Murthy Ch. Ram Reddy B. Surya Prakash 《Indian journal of clinical biochemistry : IJCB》2006,21(1):34-40
Prostate Specific Antigen (PSA) has emerged as the most applicable and important tumor marker for carcinoma prostate. In the
present study PSA was determined in serum of healthy subjects, patients of benign prostate hypertrophy (BPH) and Carcinoma
Prostate (Ca−P) to evaluate its diagnostic efficiency in day to day management of prostate cancer patients and in differentiating
patients of early prostate cancer from those with BPH. Receiver operating characteristic curve (ROC) revealed 2 ng/ml and
10 ng/ml cut off serum PSA level for BPH and untreated carcinoma prostate patients (Ca−P). An extremely significant increase
(P<0.0001) was observed in mean PSA concentration in BPH patients and adenocarcinoma prostate patients when compared to healthy
males. Clinical relevance of PSA was highlighted by a case study of cancer patient prior to any therapy till death. 相似文献
163.
Externalities as conventionally defined miss many of the spillovers that are both causes and consequences of the technological changes that underlie economic growth. We introduce a much wider concept called technological complementarities. New general purpose technologies (GPTs) rejuvenate the growth process by creating technological complementarities, which are adequately measured neither by total factor productivity (TFP) nor by externalities. There would be major gains from technological change even if the returns on capital invested in innovation never exceeded the returns on investing in existing technologies so that there were neither externalities nor positive changes in TFP. 相似文献
164.
Previous papers on grey literature by the authors have described (1) the need for formal metadata to allow machine understanding
and therefore scalable operations; (2) the enhancement of repositories of grey (and other) e-publications by linking with
CRIS (Current Research Information Systems); (3) the use of the research process to collect metadata incrementally reducing
the threshold barrier for end-users and improving quality in an ambient GRIDs environment. This paper takes the development
one step further and proposes “intelligent” grey objects. The hypothesis is in 2 parts: (1) that the use of passive catalogs
of metadata does not scale (a) in a highly distributed environment with millions of nodes and (b) with vastly increased volumes
of R&D output grey publications with associated metadata; (2) that a new paradigm is required that (a) integrates grey with
white literature and other R&D outputs such as software, data, products and patents (b) in a self-managing, self-optimizing
way and that this paradigm manages automatically curation, provenance digital rights, trust, security and privacy. Concerning
(1) existing repositories provide catalogs; harvesting takes increasing time ensuring non-currency. The end-user expends much
manual effort/intelligence to utilize the results. The elapsed time of (1) the network (2) the centralized (or centrally controlled
distributed) catalog server searches (3) end-user intervention becomes unacceptable. Concerning (2) there is no paradigm currently
known to the authors that satisfies the requirement. Our proposal is outlined below. Hyperactive combines both hyperlinking
and active properties of a (grey) object. Hyperlinking implies multimedia components linked to form the object and also external
links to other resources. The term active implies that objects do not lie passively in a repository to be retrieved by end-users.
They “get a life” and the object moves through the network knowing where it is going. A hyperactive grey object is wrapped
by its (incrementally recorded) formal metadata and an associated (software) agent. It moves through process steps such as
initial concept, authoring, reviewing and depositing in a repository. The workflow is based on the rules and information in
the corporate data repository with which the agent interacts. Once the object is deposited, the agent associated with it actively
pushes the object to the end-users (or systems) whose metadata indicate interest or an obligation in a workflowed process.
The agents check the object and user (or system) metadata for rights, privacy, security parameters, and for any charges and
assure compatibility. Alternatively the object can be found passively by end-user or system agents. The object can also associate
itself with other objects forming relationships utilising metadata or content. Declared relationships include references and
citations; workflowed relationships include versions and also links to corporate information and research datasets and software;
inferenced relationships are discovered relationships such as between documents by different authors developed from an earlier
idea of a third author. Components of this paradigm have been implemented to some extent. The challenge is implementing—respecting
part two of the hypothesis—the integration architecture. This surely is harnessing the power of grey.
相似文献
Anne AssersonEmail: |
165.
Research‐practice partnerships offer counselor educators an opportunity to generate scholarship that can promote client welfare and create systemic change in practice and policy. The purpose of this article is to articulate strategies for building and sustaining research‐practice partnerships, as well as suggest methods for evaluating these partnerships. 相似文献
166.
Rees Lewis Daniel G. Gerber Elizabeth M. Carlson Spencer E. Easterday Matthew W. 《Educational technology research and development : ETR & D》2019,67(4):953-982
Educational technology research and development - Authentic project-based learning (APBL) is a highly effective way for instructors to help students learn disciplinary skills, modes of thinking,... 相似文献
167.
Cultural Studies of Science Education - Alexis Patterson’s paper researches equity in groupwork in the science classroom by looking at micro-interactions. She points to the key features of... 相似文献
168.
169.
170.
Gary G. Brannigan Sharron M. Aabye Leslie A. Baker G. Terrence Ryan 《Psychology in the schools》1995,32(1):24-26
This study compared the Qualitative Scoring System for the modified version of the Bender-Gestalt Test and the Developmental Scoring System for the Bender-Gestalt Test in predicting performance on the Metropolitan Achievement Test. The subjects were 409 first through fourth graders from regular classes in a public elementary school. Both scoring systems correlated significantly with school achievement. However, the Qualitative system correlated higher than the Developmental system with all Metropolitan Achievement Test subscores. Tests for differences between correlations indicated that five of these comparisons were statistically significant. 相似文献