Fault tolerant cooperative control for affine multi-agent systems: An optimal control approach

The goal of this paper is to propose an optimal fault tolerant control (FTC) approach for multi-agent systems (MASs). It is assumed that the agents have identical affine dynamics. The underlying communication topology is assumed to be a directed graph. The concepts of both inverse optimality and partial stability are further employed for designing the control law fully developed in the paper. Firstly, the optimal FTC problem for linear MASs is formulated and then it is extended to MASs with affine nonlinear dynamics. To solve the Hamilton-Jacobi-Bellman (HJB) equation, an Off-policy Reinforcement Learning is used to learn the optimal control law for each agent. Finally, a couple of numerical examples are provided to demonstrate the effectiveness of the proposed scheme.     

Preparation,Characterization and Cytotoxic Effects of Pegylated Nanoliposomal Containing Carboplatin on Ovarian Cancer Cell Lines

Carboplatin is a chemotherapeutic agent used against various malignancies such as ovarian carcinoma. The aim of this study is to improve the therapeutic efficacy of carboplatin using pegylated liposomal nanocarriers. Nanoparticles were synthesized using thin film hydration technique and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, A2780S and A2780CP ovarian cancer cell lines were used to determine the efficacy of nanodrug by MTT assay. The particle size and zeta potential of nanodrug were measured 244.3 ± 19.6 nm and ?22.9 ± 1.7 mV, respectively. High encapsulation capacity (78.6 ± 3.7 %) confirmed the efficiency of technique. The cytotoxicity results also showed that nanodrug compared to free drug improve the efficacy of carboplatin against both A2780S (P < 0.01) and A2780CP (P < 0.05) cell lines. In conclusion, the findings of our study suggested pegylated liposomal nanocarriers are proper for carboplatin delivery to ovarian cancer cell lines A2780S and A2780CP.