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41.
M. Skolimowski M. Weiss Nielsen F. Abeille P. Skafte-Pedersen D. Sabourin A. Fercher D. Papkovsky S. Molin R. Taboryski C. Sternberg M. Dufva O. Geschke J. Emnéus 《Biomicrofluidics》2012,6(3)
A modular microfluidic airways model system that can simulate the changes in oxygen tension in different compartments of the cystic fibrosis (CF) airways was designed, developed, and tested. The fully reconfigurable system composed of modules with different functionalities: multichannel peristaltic pumps, bubble traps, gas exchange chip, and cell culture chambers. We have successfully applied this system for studying the antibiotic therapy of Pseudomonas aeruginosa, the bacteria mainly responsible for morbidity and mortality in cystic fibrosis, in different oxygen environments. Furthermore, we have mimicked the bacterial reinoculation of the aerobic compartments (lower respiratory tract) from the anaerobic compartments (cystic fibrosis sinuses) following an antibiotic treatment. This effect is hypothesised as the one on the main reasons for recurrent lung infections in cystic fibrosis patients. 相似文献
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Volianitis S Dawson EA Dalsgaard M Yoshiga C Clemmesen J Secher NH Olsen N Nielsen HB 《Journal of sports sciences》2012,30(2):149-153
Reduced hepatic lactate elimination initiates blood lactate accumulation during incremental exercise. In this study, we wished to determine whether renal lactate elimination contributes to the initiation of blood lactate accumulation. The renal arterial-to-venous (a-v) lactate difference was determined in nine men during sodium lactate infusion to enhance the evaluation (0.5 mol x L(-1) at 16 ± 1 mL x min(-1); mean ± s) both at rest and during cycling exercise (heart rate 139 ± 5 beats x min(-1)). The renal release of erythropoietin was used to detect kidney tissue ischaemia. At rest, the a-v O(2) (CaO(2)-CvO(2)) and lactate concentration differences were 0.8 ± 0.2 and 0.02 ± 0.02 mmol x L(-1), respectively. During exercise, arterial lactate and CaO(2)-CvO(2) increased to 7.1 ± 1.1 and 2.6 ± 0.8 mmol x L(-1), respectively (P < 0.05), indicating a -70% reduction of renal blood flow with no significant change in the renal venous erythropoietin concentration (0.8 ± 1.4 U x L(-1)). The a-v lactate concentration difference increased to 0.5 ± 0.8 mmol x L(-1), indicating similar lactate elimination as at rest. In conclusion, a -70% reduction in renal blood flow does not provoke critical renal ischaemia, and renal lactate elimination is maintained. Thus, kidney lactate elimination is unlikely to contribute to the initial blood lactate accumulation during progressive exercise. 相似文献
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S.S. Nielsen 《Journal of Food Science Education》2004,3(2):21-25
ABSTRACT: Two of the challenges in teaching Food Analysis are bringing relevance to the various chemical and physical analyses discussed and exposing students to the realities of quality assurance in the food industry. In a project to help meet those objectives, each student, with the assistance of a "resource person" from the food industry, completes the project as if he or she is responsible for the quality assurance analyses of a specific food product in a food company. The student identifies the chemical, physical, sensory, and microbial analyses for raw ingredients, in-process products, and the finished product. The project requires the student to participate in related class discussion, prepare a final written report, and make a brief class presentation. Analysis of survey data showed the project was more than moderately relevant or useful to former students working in the food industry, and related directly to the initial or current positions of most former students. 相似文献
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Ninger Zhou Nielsen L. Pereira Tarun Thomas George Jeffrey Alperovich Joran Booth Senthil Chandrasegaran Jeffrey David Tew Devadatta M. Kulkarni Karthik Ramani 《Journal of Science Education and Technology》2017,26(5):481-493
The societal demand for inspiring and engaging science, technology, engineering, and mathematics (STEM) students and preparing our workforce for the emerging creative economy has necessitated developing students’ self-efficacy and understanding of engineering design processes from as early as elementary school levels. Hands-on engineering design activities have shown the potential to promote middle school students’ self-efficacy and understanding of engineering design processes. However, traditional classrooms often lack hands-on engineering design experiences, leaving students unprepared to solve real-world design problems. In this study, we introduce the framework of a toy design workshop and investigate the influence of the workshop activities on students’ understanding of and self-efficacy beliefs in engineering design. Using a mixed method approach, we conducted quantitative analyses to show changes in students’ engineering design self-efficacy and qualitative analyses to identify students’ understanding of the engineering design processes. Findings show that among the 24 participants, there is a significant increase in students’ self-efficacy beliefs after attending the workshop. We also identified major themes such as design goals and prototyping in students’ understanding of engineering design processes. This research provides insights into the key elements of middle school students’ engineering design learning and the benefits of engaging middle school students in hands-on toy design workshops. 相似文献
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Paul Agron Leo Bachmair Frank Nielsen 《International journal for the advancement of counseling》1992,15(2):91-101
Articles
Psychosocial aspects in the German unification process 相似文献50.
On the status of critical theory 总被引:1,自引:0,他引:1
Kai Nielsen 《Interchange》1992,23(3):265-284
Critical theory, while remaining in part a scientific social theory, is not just a scientific theory. The nature and distinctiveness of its criticalness is depicted. The logical status of a rationally reconstructed Habermasian critical theory is displayed, defended from some traditional criticisms (including charges of historical idealism), and contrasted with both historical versions of critical theory and purely scientific theories. Whether the critical theory articulated and defended is Habermasian, or a more historicized critical theory, in either case it is argued that it provides a sound basis forideologiekritik against postmodernist scepticism. 相似文献