Gradual distraction with an external fixator is a widely used treatment for severe postburn ankle contracture (SPAC). However, application of external fixators is complex, and conventional two-dimensional (2D) imaging-based surgical planning is not particularly helpful due to a lack of spatial geometry. The purpose of this study was to evaluate the surgical planning process for this procedure with patient-specific three-dimension-printed models (3DPMs). In this study, patients coming from two centers were divided into two cohorts (3DPM group vs. control group) depending on whether a 3DPM was used for preoperative surgical planning. Operation duration, improvement in metatarsal-tibial angle (MTA), range of motion (ROM), the American Orthopedic Foot and Ankle Society (AOFAS) scores, complications, and patient-reported satisfaction were compared between two groups. The 3DPM group had significantly shorter operation duration than the control group ((2.0±0.3) h vs. (3.2± 0.3) h, P<0.01). MTA, ROM, and AOFAS scores between the two groups showed no significant differences pre-operation, after the removal of the external fixator, or at follow-up. Plantigrade feet were achieved and gait was substantially improved in all patients at the final follow-up. Pin-tract infections occurred in two patients (one in each group) during distraction and were treated with wound care and oral antibiotics. Patients in the 3DPM group reported higher satisfaction than those in the control group, owing to better patient-surgeon communication. Surgical planning using patient-specific 3DPMs significantly reduced operation duration and increased patient satisfaction, while providing similar improvements in ankle movement and function compared to traditional surgical planning for the correction of SPAC with external fixators.
Two isomers ofnitrochlorobenzene (o- andp-NCB) were treated by a Pd/Fe catalyst in aqueous solutions through catalytic amination and dechlorination. Nitrochlorobenzenes are rapidly converted to form chloroanilines (CAN) first through an amination process, and then rapidly dechlorinated to become aniline (AN) and CI^-, without the involvement of any other intermediate reaction products. The amination and dechlorination reaction are believed to take place predominantly on the surface site of the Pd/Fe catalysts. The dechlorination rate of the reductive degradation of the two isomers of nitrochlorobenzene (o-, and p-NCB) in the presence of Pd/Fe as a catalyst was measured experimentally. In all cases, the reaction rate constants were found to increase with the decrease in the Gibbs free energy (correlation with the activation energy) of NCBs formation; the activation energy of each dechlorination reaction was measured to be 95.83 and 77.05 kJ/mol, respectively for o- and p-NCB. The results demonstrated that p-NCBs were reduced more easily than o-NCBs. 相似文献
The bio-dissimilation of glycerol to 1,3-propanediol (1,3-PD) is a complex bioprocess due to the multiple inhibitions of substrate and products onto the cell growth. In consideration of both the inhibition mechanisms of 3-hydroxypropionaldehyde (3-HPA) and the transport modes of glycerol and 1,3-PD across the cell membrane, we establish a novel switched system which is represented by a ten-dimensional nonlinear dynamical equation containing both extracellular and intracellular environments. The uncoupled microbial fed-batch fermentation process are modeled using the switched system which the glycerol and alkali are respectively poured into. Taking the feeding rates of glycerol and alkali, the switching times and the mode sequence as the control variables, an optimal control model is proposed with the concentration of the terminal time 1,3-PD as performance index. In order to maximize the yield of 1,3-PD, the control parameterization technique and the exact penalty function method are used to solve the considered problem. Numerical results show that under the obtained optimal feeding rates of glycerol and alkali, switching times and mode sequence, the productivity of 1,3-PD at the terminal time is increased significantly compared with previous results. 相似文献